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Afnan Al-Menhali,Aisha Al-Rumaihi,Hana Al-Mohammed,Hana Al-Mazrooey,Maryam Al-Shamlan,Meaad AlJassim,Noof Al-Korbi,Ali Hussein Eid 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
Colorectal cancer (CRC) remains one of the most common malignancies and a leading cause of cancer-related deaths. Its prognosis remains poor for patients with several grades of this disease. This underscores the need for alternative modalities, such as herbal medicines, to treat this disease. A commonly used plant that appears to be of high medicinal value is Thymus vulgaris L. However, the effects of this plant on the malignant behavior of human CRC cells remains poorly investigated. This study was undertaken to determine the anticancer efficacy of T. vulgaris extract (TVE) in CRC cells. Our results show that TVE inhibits proliferation in a concentration- and time-dependent fashion. This decreased proliferation was concomitant with increased apoptotic cell death as evidenced by increased caspase3/7 activity.Moreover, TVE also decreased adhesion to fibronectin in a concentration-dependent manner. The migratory and invasive capacities of HCT116 cells were significantly inhibited by TVE. Taken together, these data suggest that the TVE inhibits malignant phenotype of colon cancer cells. Therefore, T. vulgaris could have an anticancer effect and that some of its bioactive compounds may prove to be effective treatment modalities for human CRC.
Delayed postpartum regression of theca lutein cysts with maternal virilization: A case report
Sanghwa Kim,Inha Lee,Eunhyang Park,Yeo Jin Rhee,Kyeongmin Kim,Aminah Ibrahim Aljassim,Joo Hyun Park,Jae Hoon Lee,Bo Hyon Yun,Seok Kyo Seo,Sihyun Cho,Young Sik Choi,Byung Seok Lee 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.4
Theca lutein cysts are rare, benign lesions responsible for gross cystic enlargement of both ovaries during pregnancy. This condition is also termed hyperreactio luteinalis. Elevated human chorionic gonadotropin (hCG) levels or states of hCG hypersensitivity seem to promote these changes, which in up to 30% of patients produce clinical signs of hyperandrogenism. Given the self-limiting course of theca lutein cysts, which are subject to spontaneous postpartum resolution, conservative treatment is the mainstay of patient management. Described herein is a rare case of theca lutein cysts with maternal virilization that failed to regress by 9 months after childbirth. Surgical intervention was eventually undertaken, necessitated by adnexal torsion.