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- 저자 : Agrawa, D.K. (검색결과 2 건)
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( Kumar Krishna Agrawaal ),( Prahald Karki ),( Nikesh Shrestha ),( Madhab Lamsal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Cardiac biomarkers provide a convenient and noninvasive means to gain insights into the underlying causes and consequences of ACS that mediate the risk of recurrent events and may be targets for specifi c treatment. The role of high sensitivity C reactive protein (hsCRP) for predicting the outcome has been established.There are studies to show the prognostic importance of estimated glomerular fi ltration rate. But our population differs genetically and environmentally as compared to west. Methods: It was a Prospective observational study. The Primary Outcome was taken as all cause mortality.Consecutive patients with the diagnosis of acute coronary syndrome giving consent for the study were enrolled and followed up at 6 weeks and 6 months. Mortality and the likely cause of death were recorded along with the day since admission. HS CRP was estimated on admission, at 6 weeks and at 6 months. The eGFR was calculated using the abbreviated MDRD formula at admission, at 6 weeks and 6 months. Results: There were 108 cases of ACS in duration of 6 months.The study showed 44% of patients had STEMI; 41% had NSTEMI and 23% had UA. The HS-CRP level of > 5mg/dl was highly signifi cant for predicting mortality during hospital stay and at 6 weeks (p-<0.001). There was 11% of in hospital mortality (p<0.001). At 6 months the overall mortality was 28% (p-<0.001). Arrhythmias were observed in 27% patients (p<0.001). Cardiogenic shock complicating STEMI resulted in high patient mortality (p-0.001). There was a statistical signifi cance with low eGFR (median eGFR 45 ml/ min/1.73 m2) levels during the admission. Illiteracy, Smoking and diabetes mellitus of duration more than 10 years was associated with increased risk of mortality. Conclusions: HS CRP> 5mg/dl, the eGFR levels =30ml/min/1.73 m2, Age >75 years, albuminuria and cardiogenic shock were signifi cant in predicting mortality in patients of ACS.
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Prabhu, T.M.,Devakumar, C.,Sastry, V.R.B.,Agrawa, D.K. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.3
Various products of karanj (Pongamia glabra) are utilized for industrial, health and animal agriculture applications in the Indian subcontinent. Despite a rich source of protein (CP, 28-34%), karanj cake was found to be slightly bitter in taste and toxic owing to the presence of flavonoid (Karanjin), restricting its safe inclusion in the livestock diets. Feeding trials with raw cake revealed its poor palatability and adverse performance among different categories of livestock including poultry. The present study was, therefore, aimed to detoxify karanj cake by various physico-chemical methods like solvent extraction, water washing, pressure cooking and alkali and acid treatments. The level of residual karanjin in raw and variously processed cake was quantified using high performance liquid chromatography (HPLC). The raw expeller karanj cake was found to contain about 0.19% of karanjin. Though a non-polar solvent, soxhlet extraction of expeller pressed cake with petroleum ether drastically reduced karanjin content (0.01%). Soaking of cake for 24 h in 1% NaOH (w/w) solution was found to reduce karanjin to a major extent with little further benefit by increasing alkali level. Milder alkalies like lime and fertilizer grade urea reduced the karanjin levels marginally. Similar was the case with mineral acids such as HCl and glacial acetic acid. It was, therefore, concluded that solvent extraction of karanj seeds would be the best method of detoxification as well as for more recovery of oil and karanjin.
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