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ATSUSHI SAWADA,HISASHI SATO 한국원자력학회 2010 Nuclear Engineering and Technology Vol.42 No.1
Experimental examinations for evaluating fractures were conducted by using transparent replicas of a single fracture in order to obtain the fracture data to contribute to the methodology on how to improve the definition of representative parameter values used for a parallel plate fracture model. Quantitative aperture distribution and quantitative tracer concentration data at each point in time were obtained by measuring the attenuation of transmitted light through the fracture in high spatial resolution. The representative aperture values evaluated from the multiple different measurement methods, such as arithmetic mean of aperture distribution measured by the optical method, transport aperture evaluated from the tracer test, and average aperture evaluated from the fracture void volume measurement converged to a unique value that indicates the accuracy of this experimental study. The aperture data was employed for verifying the numerical simulation under the assumption of Local Cubic Law and showed that the calculated flow rate through the fracture is 10% – 100% larger than hydraulic test results. The quantitative tracer concentration data is also very valuable for validating existing numerical code for advection dispersion transport in-plane heterogeneous fractures.
Sawada, Atsushi,Sato, Hisashi Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.1
Experimental examinations for evaluating fracutres were conducted by using transparent replicas of a single fracture in order to obtain the fracture data to contribute to the methodlogy on how to improve the definitaion of representative parameter values used for a parallel plate fracture model. Quantitative aperture distribution and quantitative tracer concentration data at each point in time were obtained by measuring the attenuation of transmitted light through the fracture in high spatial resolution. the representative aperture values evaluated from the multiple different measurement methods, such as arithmetic mean of aperture distribution measured by the optical method, transport aperture evaluated from the tracer test, and average aperture evaluated from the fracture void volume measurement converged to a unique value that indicates the accuracy of this experimental study. The aperture data was employed for verifying the numerical simulation under the assuption of Local Cubic Law and showed that the calculated flow rate through the fracture is 10%-100% larger than hydraulic test results. The quantitative tracer concentration data is also very valuable for validating existing numerical code for advection dispersion transport in-plane heterogeneous fractures.
Kochi, Yuta,Yamada, Ryo,Suzuki, Akari,Harley, John B,Shirasawa, Senji,Sawada, Tetsuji,Bae, Sang-Cheol,Tokuhiro, Shinya,Chang, Xiaotian,Sekine, Akihiro,Takahashi, Atsushi,Tsunoda, Tatsuhiko,Ohnishi, Yo Nature Publishing Group 2005 Nature genetics Vol.37 No.5
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-κB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.