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서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.8
Background: Reticulum fibers represent a special type of thin collagen fiber that measures from 0.2 to 1.0μm in diameter. A reticulum stain is currently used for diagnosing liver cirrhosis, chemodectoma, differentials of lymphoid tissue tumors and vascular tumors. In particular, it has been used for diagnosing sarcoidosis in the field of dermatology. Objective: This study was conducted to ascertain whether reticulum fibers appeared when diseases showing granulomatous reaction were stained with a reticulum stain. Methods: Patients who had been clinically or histopathologically diagnosed as having a granulomatous disease were used in this study. Granulomatous diseases included: sarcoidosis, leprosy, skin tuberculosis, lupus miliaris disseminatus faciei, granuloma annulare, paraffinoma, silicon granuloma or foreign body granuloma. A patient without a graunlomatous disease was used as the control. Hematoxylin-eosin staining and reticulum staining using Gomori`s silver impregnation method were performed in all cases. Results: A reticulum stain revealed a network of reticulum fibers surrounding and permeating the granulomas of various forms in patients with a granulomatous disease, although it was less abundant in sarcoidosis. Conclusion: We concluded that reticulum fibers appear in all granulomatous diseases. (Korean J Dermatol 2006;44(8):925~930)
우리나라에서 패혈증 환자와 굴로부터 분리한 Vibrio vulnificus균주의 생체군 분석
서필승 ( Phil Seung Seo ),김보석 ( Bo Suk Kim ),김신무 ( Shin Moo Kim ),박석돈 ( Seok Don Park ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.11
Background: Vibrio vulnificus are divided into 3 biogroups based on their biochemical and serological properties and the existence of eel virulence. Only a few studies can be found on the biogroups of V. vulnificus in other countries, and no such studies have been done in Korea. Objective: The aim of this study was to determine the presence of biogroups other than biogroup 1 among the V. vulnificus isolated from septic patients and from oysters in Korea. Methods: A total of 103 isolates (53 from septic patients and 50 from oyster) were used. The API 20E system was used to confirm identification of the V. vulnificus. Conventional biochemical tests and vvA gene detection by polymerase chain reaction (PCR) were used to determine the biogroups. Results: The clinical and oyster isolates showed results similar to the biochemical tests. All of the clinical and oyster isolates showed the biochemical pattern of biogroup 1. The vvhA gene was detected in all of the isolates. Conclusion: All of the V. vulnificus isolates from the septic patients and oysters in Korea belong to biogroup 1. (Korean J Dermatol 2008; 46 (11): 1453∼1456)
원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.3
Background: Exposure to Rhus (Japanese lacquer) can cause many adverse effects such as contact dermatitis, pruritus, rash and even hepatitis in human, and these effects can be caused by contact or ingestion of Japanese lacquer. Many Koreans currently eat Japanese lacquer boiled with chicken although it has many side effects. Koreans believe that Rhus will improve their health. However, they don`t known its adverse effects, and there is no experimental report on this topic. Objective: The principle objective of this study was to gather evidence on the toxicity and negative effects of Japanese lacquer through an experimental study with rats. Methods: A total of 60 Sprague-Dawley rats were included in the study; 30 rats (experimental group) were given 0.1 ml of Japanese lacquer sap extract, water and food, and 30 rats (control group) were given only food and water. The WBC, the Hgb, ALT, AST, BUN and creatinine levels, the presence of pruritis and skin eruption, the skin biopsy findings and the liver biopsy findings were all checked at 5, 10, and 15 days. Results: The rats that were given Japanese lacquer sap showed a higher WBC and higher ALT and AST levels and only these rats demonstrated erythroderma (5th day: 30%, 10th day: 40%, 15th day: 70%). In addition, they exhibited frequently scratching behavior. On histological examination of the skin of the rats given Rhus, dermal edema and mild inflammatory cell infiltration were found. On histological examination of the liver of the rats given Rhus, there was no significant change as compared with the rats that weren`t given lacquer. Conclusion: In this experimental study, it was proven that Rhus could induce pruritis, erythroderma, skin inflammation and hepatotoxicity. (Korean J Dermatol 2009;47(3):251∼258)
옻닭에 의한 전신성 접촉 피부염 147예의 임상적 고찰
원태혁 ( Tai Hyok Won ),서필승 ( Phil Seung Seo ),박석돈 ( Seok Don Park ),김동림 ( Dong Lim Kim ),박재훈 ( Jae Hun Park ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.6
Background: Systemic contact dermatitis (SCD) due to the ingestion of Japanese lacquer tree (Rhus verniciflua) is pretty common in Korea, and it is on a trend of increment. It is thought that the increase in ingestion of chickens boiled with the lacquer tree has been caused by the regard of the lacquer tree as a health food or herbal medicine for gastrointestinal disease. Objective: To review the clinical findings and laboratory findings, and to make people aware of the harmful effects of the lacquer tree. Methods: We retrospectively reviewed the medical records of 147 patients who had SCD due to chicken boiled with lacquer tree, 98 patients in Wonkwang University Hospital over the last 20 years (1998∼2007) and 49 patients in Areumdaun Dermatology Clinic over the past 5 months (August∼December, 2007). Results: The sex ratio of patients (male to female) was 1.3:1 and the average age was 44.0 years old (range: 11∼76). They ate chicken boiled with lacquer tree as a health food (42.9%) and for the treatment of gastrointestinal disease (22.4%). The mean incubation period was 47.7 hours (range: 30 min∼16 days). The first symptoms they had were erythematous maculopapules (42.9%), itching without rash (33.7%), and edematous change (16.3%). The skin lesions developed as maculopapules (50.6%), erythroderma (40.9%), and erythema multiforme-like lesion (8.4%), vesicles, wheals, purpura, and pustules. On laboratory findings, some people had leukocytosis (61.2%), increment of Ig E (26.4%), abnormalities of liver function test (ALT:16.3%, AST:4.1%). Sixty percent of patients had a history of contact dermititous contracted via chicken boiled with rhus lacquer ingestion (36.7%) or contact with the lacquer tree. Clinical symptoms were developed by 29.5% who ate chicken boiled with lacquer. Mainly they had been treated with corticosteroids, antihistamines. The mean period needed for treatment was 8±2.4 days. Conclusion: Systemic contact dermatitis due to ingestion of the lacquer tree was developed in either sensitized or non-sensitized persons. It is suggested that SCD is caused by the highly allergic and toxic effects of lacquer. Physicians need to make people aware of the harmful effects of the lacquer tree and educate people not to ingest it. (Korean J Dermatol 2008;46(6):761∼768)