Case Report : A Case of Fibroelastolytic Papulosis on the Neck of a Young Man

( Young Chan Song ),( Byung Ho Oh ),( Jong Hyun Ko ),( Ji Young Kim ),( Young Ji Hwang ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ),( Kyae Yong Song ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2

Fibroelastolytic papulosis of the neck (FEPN) encompasses a spectrum of two disorders that were previously reported as pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) and white fibrous papulosis of the neck (WFPN). The clinical presentation of FEPN is asymptomatic to mildly pruritic whitish-yellow papules that may coalesce into cobblestone patterned plaques that resemble pseudoxanthoma elasticum (PXE). The histology is characterized by a decrease or loss of elastic fibers in the papillary dermis and this is sometimes accompanied by a minimal or nodular increase of dermal collagen fibers. We report here on a 28-year-old Korean man with asymptomatic, multiple, skin-colored to slightly yellowish, match-head sized, cobblestone-patterned papules on the neck, and these were histologically consistent with FEPN and the papules showed slightly increased dermal collagen associated with decreased and fragmented elastic fibers, elastin and tropoelastin. The pathogenesis of FEPN in this case might have been related with mild dermal inflammation, followed by fragmentation, elastolysis and increased dermal collagen. (Ann Dermatol 23(2) 193∼197, 2011)

Two Cases of Cutaneous Protothecosis : Unique Histopathological Findings with Crystal Violet Staining and the Therapeutic Effect of Itraconazole

문상은,김종애,Kyae Yong Song 대한피부과학회 1997 Annals of Dermatology Vol.9 No.3

Cutaneous protothecosis sometimes poses diagnostic and therapeutic problems. Isolation of the causative organism may not be successful and spores may be mistaken for other skin diseases unless the characteristic sporangia are detected in tissue sections. Because there are few cases, the optimal therapy is still being debated. On Lieb's crystal violet staining we found charateristic purplish dots in Prototheca spores; these correspond to the amyloplasts or dense bodies found under electron microscopy. The isolated organisms were inhibited in vitro by itraconazole, amphotericin B, ketoconazole, and amorolfine and we were able to successfully treat two patients with itraconazole.

Prevalence of the Metabolic Syndrome and Associated Factors in Korean Cancer Survivors

Lee, Jung-Yun,Park, Noh Hyun,Song, Yong-Sang,Park, Sang Min,Lee, Hae-Won,Kim, Kyae Hyung,Choi, Kyung-Hyun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: This study was designed to evaluate prevalence of the metabolic syndrome among cancer survivors compared to non-cancer controls from a population-based sample and to identify associated risk factors. Materials and Methods: Data from the fourth Korean National Health and Nutrition Examination Survey were analyzed to compare the prevalence of metabolic syndrome, as defined by 2009 consensus criteria. Associated factors with were identified using multiple logistic regression analysis among cancer survivors. Results: The prevalence of the metabolic syndrome in cancer survivors (n = 335) was similar to that in the non-cancer population (n = 10,671). However, gastric cancer survivors showed lower risk of metabolic syndrome than non-cancer controls (adjusted odds ratio [aOR] 0.42, 95% confidence interval [CI] 0.20-0.86). Age of more than 60 years (aOR 4.83, 95% CI 1.94-12.03), BMI between 23 and 25 (aOR 6.71, 95% CI 2.90-15.6), BMI more than 25 (aOR 12.23, 95% CI 5.20-28.77) were significantly associated with the metabolic syndrome in cancer survivors. Conclusions: Cancer survivors are unlikely to have a higher risk of the metabolic syndrome than non-cancer controls in Korea. This finding may be due to a relatively high proportion of gastric cancer survivors in Korea than in Western countries. The risk for metabolic syndrome among cancer survivors would appear to vary according to oncological and non-oncological factors.

Cases of Linear Focal Elastosis

( Jong Kyeong Kim ),( Tae Jin Yoon ),( Chee Won Oh ),( Tae Heung Kim ),( Kyae Yong Song ) 대한피부과학회 1995 대한피부과학회 학술발표대회집 Vol.47 No.2

자외선 B가 무모생쥐의 피부 장벽대 기능에 미치는 영향 - 경피적 수분소실과 피부각질층 지질의 변화 -

윤두희,김형옥,김태윤,김정원,송계용 ( Dou Hee Yoon,Hyung Ok Kim,Tae Yoon Kim,Chung Won Kim,Kyae Yong Song ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.4

피부 각질층은 피부의 가장 바깥층으로 포유동물에서 외부의 유해 자극으로 부터 자신을 보호하고 외부 물질의 피부 흡수 조절과 건조한 주위환경으로 포피에서의 과도한 수분증발을 방지하는 등 매우 중요한 기능을 담당한다. 각질층 지질이 피부장벽대(skin barrier function)의 주 역할인 각질층내 수분 유지기능(water holding function)과 함께 외부 수분 유입에 대한 투과 장벽대(water permeability barrier)등의 중요한 역할을 함이 알려져 있다. 이런 각질층 지질은 ceramide가 80%인 sphingolipid와 유리 지방산(free fatty acid) 및 콜레스테롤(cholesterol)이 주인 중성 지질(neutral lipid)등이 대부분이며, 각질화가 진행될수록 그 양의 증가를 보이는 sphingolipid와 유리 지방산(free fatty acid) 및 콜레스테롤(cholesterol)이 주인 중성 지질(neutral lipid)등이 대부분이며, 각질화가 진행될수록 그 양의 증가를 보이는 sphingolipid 계열의 지질들이 강력한 수소 결합력을 가져 수분 유지기능에 가장 중요한 역할을 한다. 자외선 조사는 피부의 물리적 생화학적 성상의 변화를 초래하여 홍반의 발생, 상피세포의 증식, 과색소 침착, DNA 손상, 각종 효소와 단백질의 활성 내지는 비활성, 유리 산소(oxygen radical)의 형성과 Vitamin-D_3합성 등이 있다. 자외선 조사후의 각질층 지질의 변화는 각 보고자의 실험 대상, 자외선 조사의 차이와 지질 분석의 방법에 따라서 다른 결과를 나타내기도 하였다. 본 실험에서 저자들은 정상 피부에 자극 반응을 일으키지 않는 저용량(suberythemal dose, SED)과 자극을 일으키기 시작하는 최소 홍반량(minimal srythemal dose, MED)의 자외선 B를 1주에 이틀간격으로 3회씩 3주간 반복조사함으로써 지속적인 자외선의 조사가 피부 장벽대에 시간대별로 미치는 영향과 고용량의 자외선 B를 일시에 조사하여 피부 장벽대에 손상을 입힌 후와 그 회복과정에서의 피부장벽대의 변화를 시간대별로 evaporimeter를 이용한 transepidermal water loss(TEWL)의 측정과 high performance thin layer chromatography(HPTLC)의 방법으로 각질층 지질 분석을 통하여 자외선 B가 피부 장벽대에 미치는 영향을 알아보고자 본 연구를 시도하였다. Background:Stratum corneum lipids serve as a water retainer as well as permeability barrier by forming a multi-lamellae structure in the stratum corneum. The major constituent of these lipids, ceramides, have been shown to be predominantly associated with both functions. Objective:Exposure of human epidermis to ultraviolet(UV) irradiation leads to changes in the physiologic and biochemical features of the skin. In order to investigate the effect of UVB irradiation on the skin barrier function in hairless mice, transepidermal water loss(TEWL) and lipid composition of stratum corneum were evaluated in hairless mice. Methods:Hairless mice were irradiated 3 times weekly for 3 weeks with suberythemal dose(0.6MED, Group Ⅰ) and minimal erythemal dose(MED, Group Ⅱ) of UVB. The mice of Group Ⅲ recieved high dose of UVB(3MED) on the back in a single exposure. The control was Group Ⅳ. TEWL measured by evaporimeter and lipid composition of stratum corneum appraised by high performance thin layer chromatography(HPTLC) were evaluated weekly for 3 weeks. Results: 1. Each time it was measured, the values of TEWL in group Ⅰ were lower than group Ⅳ, but the difference was not significant. The peak value of REWL in group Ⅱ was 8.2±1.56 g/㎠/h on the 7th day. The increase in TEWL was markedly significant at this point(P<0.001). Although the values of TEWL on the 14th and 21th day in group Ⅱ increased compared with those of the control group, the significance of the values decreased(P<0.05). 2. The peak value of TEWL in group Ⅲ was 9.88±1.13 g/㎠/h on the 2nd day, showed a markedly significant increase compared with that of the control group(P<0.001). The values of TEWL decreased to the level of the control group on the 14th day. 3. The lipid(cholesterol sulface, ceramide and neutral lipid) and total lipid mass in group Ⅰ were insignificantly larger than that of the group Ⅳ measured each time. On the 7th and 14th day, the amount of each three lipid and total lipid mass significantly increased(<0.05), furthermore the total lipid mass increased pronouncedly(P<0.01) in group Ⅱ. 4. The amount of the 3 kinds of lipid and total lipid mass in group Ⅲ significantly increased compared with those of the control group on the 2nd day(P<0.05). After the 7th day, no significant difference of the lipid mass except neutral lipid compared with that of the control group was seen. Comparing the 2nd and 14th day, there was a significant decrease in the amount of ceramide and total lipid mass(P<0.05). comclusion:These results suggest that considerable amount of UVB irradiation given in single or repeated exposure causes the disruption of skin barrier function, but a compensatory increase of skin lipid, sepecially ceramide, protects it from further damage and also improves skin barrier function.(Kor J Dermatol 1995;33(4):669∼678)

심부 정맥 혈전증에 속발된 가성 카포시육종

윤소영 ( So Yeong Yoon ),김경훈 ( Kyoung Hoon Kim ),서기범 ( Ki Beom Suhr ),이정덕 ( Jeong Deok Lee ),송계용 ( Kyae Yong Song ),박장규 ( Jang Kyu Park ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Pseudo-kaposi's sarcoma is a vasoproliferative disorder that may resemble Kaposi's sarcoma, clinically and histologically. In most cases, it has been associated with congenital or iatrogenic arteriovenous fistula and chronic venous insuffiency. We present a 36-year-old male patient with pseudo-Kaposi's sarcoma caused by a deed vein thrombosis in the absence of any detectable underlying etiologic factors. (Kor J Dermatol 1995;33(6): 1159-1163)

인체모낭 기관배양 시 모낭의 형태와 성장속도에 영향을 미치는 배양인자에 관한 연구

김윤성 ( Yoon Sung Kim ),김경훈 ( Kyung Hoon Kim ),이우재 ( Woo Jae Lee ),정지원 ( Ji Won Jung ),송계용 ( Kyae Yong Song ),서기범 ( Ki Beom Suhr ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Background: In order to study hair biology, a hair organ culture system is necessary. However satisfactory hair culture systems have not been established. Objective : The purpose of this study was to examine the effectiveness of growth factors and to establish a hair organ culture system for studying hair biology and to evaluate the effectiveness of growth factors. Method: After the healthy human anagen hair follicles were collected without any visible damage, they were cultured in William E medium with several combinations of growth factors including insulin, hydrocortisone, sodium selenite, human transfemn, fetal calf serum and epidermal growth factor at 37C in an atmosphere of 5% CO2/air incubation. The culture medium was changed every 3 days. The results were evaluated by measuring hair growth and hair follicle morphology. Results : The results of this study are summarized as follows; 1) In the medium composed of insulin, hydrocortisone,sodium selenite and human transferrin, the human hair follicles continued to grow at an in vivo rate of 0.3mm in a day over 10 days without change of gross and microscopic morphology. 2) In the medium containing insulin and/or hydrocortisone the growing rate of the human hair follicles was similar to that in vivo, but the follicles revealed premature entry into catagen at 2-6 days in the culture macroscopically and microscopically. 3) Adding fetal calf serum to the above medium made the hair follicles retain the freshly isolated hair follicles morphology for 10 days in culture, even though they grew somewhat slower than the in vivo rate from 6 days in culture. 4) The effectiveness of EGF mimics the in vivo depilation of EGF in sheep. Conclusion : To supplement insulin, hydrocortisone, sodium selenite, transferrin as growth factors, William E medium was necessary for maintenance of an in vivo growth rate and the morphology the anagen hair follicles. This culture system is not enough, but it might be useful for investigation of the physiology, biology of hair follicles as well as pharmacology and toxicology in hair. (Korean J Dermatol 1998;36(2): 210-216)

Familial anetoderma

이호성(Ho Seong Lee),김태흥(Tae Heung Kim),박기범(Ki Beom Park),송계용(Kyae Yong Song) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.6

Anetoderma or Macular atrophy is a rare cutaneous disorder showing local atrophy and macular discoloration related to a local dermal defect of elastic tissiie without any other apparent change in the skin, which may show familial occurrence, called familial anetoderma. A 13-year-old female complained 3-year history of multiple asyrnptomatic atrophic macules on the trunk and both lower extremities, especially on both this. Elastic stain of skin lesion showed decrease of lastic tissue in the dermis. No other syst mic abnormalities were found on phisical examination. Her sister had same skin lesion on lower extremities and both buttocks, and had no ther systemic abnormalities. Despite infrequent occurence, the development of anetoderma among familial members possibly represents a congcnital defect of elastin. Because variou ocular, bony, cardiac, and gastrointestinal abnormalilies have been reported in familial anetoilerma, long-term follow up would be necessary. (Kor J Dermatol 1992;30(6):924-927)

Pseudallescheria boydii에 의한 진균종

김삼형 ( Sam Hyeong Kim ),홍석진 ( Seok Jin Hong ),강훈 ( Hoon Kang ),손숙자 ( Sook Ja Son ),송계용 ( Kyae Yong Song ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Pseudallescheria (P.) boydii is a true fungus that is ubiquitous in nature, and has a world-wide distribution. It has been isolated from soil, plant debris, polluted water and sewage. Infection may occur via direct inoculation or inhalation, and usually affects the extremities. It is a common cause of mycetoma characterized by tumefaction, draining sinuses and grains. It has polymorphism due to a complicated life cycle which undergoes teleomorph as well as anamorph stages. Cleistothecia, ascocarp and ascospore may be seen during the teleomorph stages, whereas scedosporium and graphium type may be seen during the anamorph stages. We report a case of P. boydii mycetoma occurring in a 69-year old male. He had multiple nodules with a discharging fistula on a dark red plaque at the dorsum of the right forearm. Cultural isolation for definitive diagnosis showed typical P. boydii. The lesion responded well to daily itraconazole. (Korean J Dermatol 1998;36(2): 341-345)