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Lee, Jai-Hyuen,Park, Seok-Gun The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.4
Purpose Patients receiving high-dose I-131 to treat differentiated thyroid cancer are isolated from visitors to limit radiation exposure to reasonable levels. The appropriate isolation time is unclear and has not been reported in Korea. The purpose of this study was to estimate the isolation time and investigate the possibility of earlier release from isolation. Methods This study was a retrospective analysis of data from 71 patients (10 men and 61 women; mean age, $49{\pm}11.1\;y$) who received 3.7 GBq (47 patients), 5.55 GBq (23 patients), or 7.4 GBq (1 patient) of I-131 between January 2008 and December 2008. The radiation dose was measured with a fixed probe placed inside the isolation room. The total estimated dose equivalent (TEDE) to family members, the time required for the external dose rate to become <0.07 mSv/h, and the time required for whole-body retention to become <1.2 GBq were calculated. Results By the TEDE criterion (<5 mSv), 70 of 71 patients (98.6%) could have been released without isolation. By the external dose rate criterion, 10 of 71 (14.1%) and 60 of 71 patients (84.5%) could have been released without isolation and within 24 h, respectively. With whole-body retention criterion, 19 of 71 (26.8%) and 48 of 71 patients (67.6%) could have been released within 24 h and within 48 h, respectively. Conclusions Appropriate release times were estimated and compared using different criteria. Most patients could have been released without isolation or within 24 h of radiation treatment.
Lee, Jai-Hyuen,Lee, Won-Ae,Park, Seok-Gun,Park, Dong-Kook,NamGung, Hwan The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Purpose : The clinical availability of 2-deoxy-2-[18F] fluoro-D-glucose (FDG) dual-time point positron emission tomography/computerized tomography (DTPP) has been investigated in diverse oncologic fields. The aim of this preliminary study was to evaluate the relationship between various immunohistopathologic markers reflecting disease progression of colorectal cancer and parameters extracted from FDG DTPP in colorectal cancer patients. Materials and Methods : Forty-seven patients with histologically confirmed colorectal cancer were analyzed in this preliminary study. FDG DTPP consisted of an early scan 1 h after FDG injection and a delayed scan 1.5 h after the early scan. Based on an analysis of FDG DTPP, we estimated the maximum standardized uptake value (SUV) of tumors on the early and delayed scans ($SUV_{early}$ and $SUV_{delayed}$, respectively). The retention index (RI) was calculated as follows: $(SUV_{delayed}-SUV_{early}){\times}100/SUV_{early}$. The clinicopathological findings (size and T and N stages) and immunohistochemical factors [glucose transporter 1 (GLUT-1), hexokinase 2 (HK-2), p53, P504S, and ${\beta}$-catenin] were analyzed by visual analysis. Results : The RIs calculated from the SUVs ranged from -1.8 to 73.4 ($31.8{\pm}15.5$). The RIs were significantly higher in patients with high T stages (T3 and T4) than with low T stages (T1 and T2; p<0.05). Among the immunohistochemical analytic markers, GLUT-1 had the highest positive staining rate (93.6%) compared to other markers. Based on univariable analysis, it was shown that the RI of high-level GLUT-1 expression was significantly higher than low-level GLUT-1 expression (p=0.01), and the RI of high-level p53 expression was slightly higher than low-level p53 expression (p=0.08). Multi-variate analysis to investigate a link between RI and clinicopathologic parameters of colorectal carcinoma showed that GLUT-1, p53, and T staging were independently connected with increased RIs (p<0.05, total) using backward selection methods. There was no significant statistical relationship between $SUV_{early}$ and $SUV{delayed}$ and clinicopathologic parameters in this study. Conclusion : The RIs obtained from preoperative colorectal cancers had a significant relationship to tumor size, T staging, GLUT-1, and p53, in contrast to $SUV_{early}$ or $SUV_{delayed}$ Compared with previous reports, our results showed that RI can better predict GLUT-1 expression than HK-2 and other immunohistochemical markers. This study demonstrated that the RI might have the potential to be applied as a prognostic marker in preoperative colorectal cancer.
Kim, Seog-Young,Jung, Jin Hwa,Lee, Haeng Jung,Soh, Hyunsu,Lee, Sang Ju,Oh, Seung Jun,Chae, Sun Young,Lee, Jai Hyuen,Lee, Seung Jin,Hong, Yong Sang,Kim, Tae Won,Moon, Dae Hyuk American Association for Cancer Research 2017 Cancer research Vol.77 No.24
<P>These findings suggest that any inhibitor with a primary target mechanism of thymidylate synthase inhibition may be combined with trifluridine/tipiracil in colon cancer and possibly other cancer types.</P><P>In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance antitumor efficacy in colon cancer xenograft models. We also examined 3'-deoxy-3′-[<SUP>18</SUP>F]fluorothymidine ([<SUP>18</SUP>F]FLT) PET as a means to predict therapeutic response to a sequential combination of capecitabine and trifluridine/tipiracil. [<SUP>3</SUP>H]FLT uptake after 5-fluorouracil treatment <I>in vitro</I> and [<SUP>18</SUP>F]FLT uptake after capecitabine (360 mg/kg/day) in athymic nude mice (Balb/c-nu) with xenografts (<I>n</I> = 10–12 per group) were measured using eight human colon cancer cell lines. We determined the synergistic effects of sequential combinations of 5-fluorouracil and trifluridine <I>in vitro</I> as well as the sequential combination of oral capecitabine (30–360 mg/kg) and trifluridine/tipiracil (trifluridine 75 or 150 mg/kg with tipiracil) in six xenograft models (<I>n</I> = 6–10 per group). We observed significant increases in [<SUP>3</SUP>H]FLT uptake in all cell lines and [<SUP>18</SUP>F]FLT uptake in five xenograft models after 5-fluorouracil and capecitabine treatment, respectively. Increased [<SUP>18</SUP>F]FLT uptake after capecitabine followed by extinction of uptake correlated strongly with tumor growth inhibition (<I>ρ</I> = −0.81, <I>P</I> = 0.02). The effects of these combinations were synergistic <I>in vitro</I>. A synergy for sequential capecitabine and trifluridine/tipiracil was found only in mouse xenograft models showing increased [<SUP>18</SUP>F]FLT uptake after capecitabine. Our results suggest that the sequential combination of capecitabine and trifluridine/tipiracil is synergistic in tumors with an activated salvage pathway after capecitabine treatment in mice, and [<SUP>18</SUP>F]FLT PET imaging may predict the response to capecitabine and the synergistic antitumor efficacy of a sequential combination of capecitabine and trifluridine/tipiracil. <I>Cancer Res; 77(24); 7120–30. ©2017 AACR</I>.</P>
Horticultural Therapy in Patients with Stroke: Three Case Series
Sung Bong Shin,Tae Uk Kim,Jai Hyuen Lee,Jung Yoon Kim,Sook Lee 한국인간·식물·환경학회 2016 인간식물환경학회지 Vol.19 No.1
Horticultural therapy (HT) is the engagement of a person in gardening related indoor activities by a trained professional to achieve specific treatment goals. It was effective as an alternative medicine and played an important role in rehabilitation of stroke patients, especially in psychological aspects. While the psychological benefit has been clearly demonstrated, the evidence of the physical benefit is insufficient. We report three stroke patients treated with HT and they were evaluated from the standpoint of physical, psychological, and cognitive outcomes. HT program consisted of 10 sessions during 2 weeks with 1 hour per session. The assessment of outcomes and positron emission tomography/computed tomography (PET/CT) were performed before and after treatment. Two patients showed improvements in physical and psychological aspects. But the other patient showed no outstanding outcome. These results suggest the possibility of HT as a complement to conventional occupational therapy.
도시철도법 및 하위법령 개정의 필요성 : 경량전철을 중심으로
홍재성(Hong Jai-Sung),이안호(Lee An-Ho),류상환(Rhy Sang-Hwan),이호용(Lee Ho-Yong),황현철(Hwang Hyuen-Chul) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.11월
"Urban Railway Vehicle" is defined by Urban Railway Act as Railway and Monorail, and so on constructed in urban area. but the differences between heavy electric motor car which operate in and near Seoul and is usually thought as urban railway vehicle and light rail vehicle which is going to be opened soon are ignored in this act. In the case of IAT in Incheon international airport and monorail constructing in Weolmi-do, Urban Railway Act is not applying to them, even though they are LRT, just because they are not constructed within traffic area in city. Most of all, Urban Railway Act should define vehicle precisely and be amended on the standard measurement, safety standard, performance test standard, construction regulation and operation regulation to test safety and performance of automatic LRT projects in the country.
Gwak, Hee Keun,Lee, Jai Hyuen,Park, Seok Gun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Background: Although various tumor markers have been utilized in management of stomach cancer (SC), only a few reports have described relevance of examples such as CYFRA 21-1 and neuron-specific enolase (NSE). The purpose of this study was to evaluate the potential diagnostic performance of carcinoembryonic antigen (CEA), CA 19-9, CA72-4, CYFRA 21-1 and NSE in patients with SC. Materials and Methods: Ninety-six SC patients with pathologic confirmation between 2012 and 2013 were enrolled. Serum levels of five tumor markers were analyzed using a solid-phase immunoradiometric assay. Receiver operating characteristic (ROC) curves were plotted for the five tumor markers to investigate their diagnostic powers and adjusted cutoff values derived from analysis of ROC curves were evaluated to calculate the sensitivity of each for SC with recommended cutoff values. Results: Based on two different cutoff values (recommended and adjusted), CYFRA 21-1 (${\geq}2.0$ and 1.2 ng/ml) had a respective sensitivity of 50% and 78.1%, compared with 8.3% and 18.8% for CEA (${\geq}7.0$ and 3.9 ng/ml), 15.6% and 18.8% for CA 19-9 (${\geq}37$ and 26.7 ng/ml), 28.1% and 9.6% for CA 72-4 (${\geq}4.0$ and 13 ng/ml) and 7.3% and 7.3% for NSE (${\geq}14.7$ and 15.0 ng/ml) in the initial staging of primary SC. The area under the curve (AUC) for CYFRA 21-1, with a value of 0.978 (95% confidence interval, 0.964-0.991) was comparatively the highest. Univariate analysis revealed significant relationships between tumor marker level and lymph node involvement, metastasis and staging with CYFRA 21-1, CA 72-4 and NSE. Conclusions: CYFRA 21-1 was the most sensitive tumor marker and showed the most powerful diagnostic performance among the five SC tumor markers. NSE and CA 72-4 are significantly related to lymph node involvement, metastasis or stage. Further evaluations are warranted to clarify the clinical usefulness and prognostic prediction of these markers in SC.