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Chemical Study on the Leaf of Prunus davidiana
Park, Jong-Hee,Kim, Jin-Soo,Lee, Jun-Do,Park, Hee-Juhn 한국자원식물학회 1997 한국자원식물학회지 Vol.10 No.1
우리나라 민간약으로서 신경통 및 류마치스의 치료에 널리 사용되고 있는 산복사나무(Prunus davidiana)의 잎으로부터 naringenin 및 그 배당체, kaempferol 및 그 배당체, kaempferide glueoside, quercetin glucoside 및 d-catechin을 단리하였다. From the leaf of Prunus davidiana, naringenin and its glucoside, kaempferol and its glucoside, kaempferide glucoside, quercetin glucoside and d-catechin were isolated.
Park, Hee-Juhn,Kwon, Sang-Hyuk,Lee, Joo-Han,Lee, Kyou-Heung,Miyamoto, Ken-ichi,Lee, Kyung-Tae 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Hederagenin, δ-hederin {hederagenin α_-L-arabinoside}, kalopanax-saponin A (hederagenin 3-O-α_-L-rhamnosyl(1→2) -α_-L-arabinoside}, kalopanaxaponin I {hederagenin 3-O-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-L-arabinoside}, and sapindoside C {hederagenin 3-O-β-_D-glucosyl(1→4)-β-_D-xylosyl(1→3)-α-_L-rhamnosyl(1→2)-α-_L-arabinoside} were isolated from stem bark of Kalopanax pictus Nakai (Araliaceae). Among glycosides of hederagenin, disaccharide (kalopanaxaponin A, commonly also called α-hederin), trisaccharide (kalopanaxaponin l), and tetrasaccharide (sapindoside C) showed significant cytotoxicity on several types of tumor cells, while hederagenin itself exhibited only weak cytotoxicity and its monosaccharide (δ-hederin) was non-cytotoxic. From these results, it suggests that the arabinosyl moiety at C-3 blocks the activity of hederagenin and the position of the second sugar for glycoside linkage is also important for cytotoxicity. In the in vivo experiments, kalopanaxsaponin A (15 mg/kg, i.p.) apparently increased the life span of mice bearing Colon 26 and 3LL Lewis lang carcinoma, as well as cisplatin (3 mg/kg, i.p.). These results indicated that kalopanaxsaponin A has potential anti-tumor applications.
Park, Young-Mi,Won, Jong-Heon,Kim, Yang-Hee,Choi, Jong-Won,Park, Hee-Juhn,Lee, Kyung-Tae EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
The mushroom Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae), has been traditionally used for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes in Russia, Poland and most of Baltic countries. This study was designed to investigate the anti-inflammatory and anti-nociceptive effects of the methanol extract from Inonotus obliquus (MEIO) in vivo and in vitro. MEIO (100 or 200㎎/(㎏ day),p.o.) reduced acute paw edema induced by carrageenin in rats, and showed analgesic activity, as determined by an acetic acid-induced abdominal constriction test and a hot plate test in mice. To reveal the mechanism of the anti-inflammatory effect of MEIO, we examined its effect on lipopolysaccharide (LPS)-induced responses in a murine macrophage cell line RAW 264.7. MEIO was found to significantly inhibit the productions of nitric oxide (NO), prostaglandin E_(2) (PGE_(2)) and tumor necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages. Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, MEIO inhibited the LPS-induced DNA binding activity of nuclear factor-κB (NF-κB), and this was associated with the prevention of inhibitor κB degradation and a reduction in nuclear p65 protein levels. Taken together, our data indicate that the anti-inflammatory and anti-nociceptive properties of MEIO may be due to the inhibition of iNOS and COX-2 expression via the down-regulation of NF-κB binding activity.
Park, Hee-Juhn,Kim, Ryung-Gue,Seo, Bo-Rim,Ha, Joohun,Ahn, Byung-Tae,Bok, Song-Hae,Lee, Yong Sup,Kim, Hyoung Ja,Lee, Kyung-Tae WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
In the present study, we demonstrate that saucernetin-8(1) and saucernetin-7 (2), isolated from the underground parts of Sauiurus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E_(2)(PGE_(2)) production in RAW 264.7 cells. Both compounds 1 and 2, known as dineolignans, also suppressed the expression of iNOS and COX-2 protein in a dose-dependent manner. Thus, this study suggests that compounds 1 and 2-mediated inhibition of iNOS and COX-2 expression may be one of the mechanisms responsible for the anti-inflammatory effects of the underground parts of Saururus chinensis.
Flavonoids from the Whole Plants of Orostachys japonicus
Park, Hee-Juhn,Young, Han-Suk,Park, Kun-Young,Rhee, Sook-Hee,Chung, Hae-Young,Choi, Jae-Sue The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.2
From the whole plants of Orostachys japonicus, kaempferol, quercetin, astragalin, quercitrin, isoquercitrin, cynaroside, afzelin, 3-O-$\alpha$-rhamnosyl-7-$\beta$-D-glucosyl kaempferol, and 3, 7-di-O-$\beta$-D-glucosyl kaempferol were isolated and characterized by spectral data.
Park, Hee Juhn,Kwon, Sang Hyuk,Han, Yong Nam,Choi, Jong Won,Miyamoto, Ken-ichi,Lee, Sung Ho,Lee, Kyung Tae 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
In a course of obtaining more amount of bioactive costunolide and successive phytochemical isolation from Magnolia siegoldii (Magnoliaceae), a novel acyclic monoterpene 1 named deoxygeranlol {2,6(E)-dimethyl-2,6-octadiene} was isolated along with β-sitosterol 3-O-linoleate (2), trilinolein (3) and high amount of costunolide (4) in the pure state. The structure of compound 1 was determined on the basis of spectroscopic data. Costunolide was found to induce apoptotic cell death in a dose-dependent manner by nucleosomal DNA ladder and flow cytometric analysis. Immunoblot analysis showed that the level of the anti-apoptotic protein, Bcl-2, was decreased, whereas the cleavage of poly-(ADP-ribose) polymerase was activated. Furthermore, the N-acetyl-L-cysteine antioxidant effectively prevented costunolide-induced cytotoxicity. These results suggest that costunolide-induced cell death is mediated by reactive oxygen species.