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人大腦帶回前部 皮質峰部(Brodmann 第24皮質分野)의 細胞構築學的 硏究
李海求 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.1
Cytoarchitectonic studies on summit of rostral half of the cingulate gyral cortex(Brodmann's area 24) has been investigated in 149 normal human brains taken from newborn till 85-years old of both the sexes of Korean. The cortical thickness and the cellularitise in the cortical summit were determined, and were compared with those values from wall of the identical cortex. The adult value of cortical thichness in 2582∼2650 micra of the summit was shown 1.20∼1.24 times thicker than that of 2093∼2170 micra at wall in identical cortex. The cellularities in both the neuronal and glial cells of the adult, 275∼299 cells cortex of the summit was shown 93.2∼97.7% of 285∼310 cells at that of wall, and that of 466∼508 cells of the glia in the summit was shown 93.7∼95.5% of 497∼540 cells at wall of the identical cortex. Among all the adult values of the summit were shown statistically significant difference in comparisons with values of the wall. except that for the thcikness in which shown significant difference. These facts were seemingly implicated that there were some of latent different morphofunctional potentialities between both the sites on the cortex orginated presumably from the developmental atmosphere during the prenatal life. None of significant sexual difference has been noted throughout present observation. It is suggested that coincidental fibrilloarchitectural studies appears to be profitable as far as the cytoarchitectural investigation of brain cortex is concern. Some of a brief histological methodology on the cytoarchitectonics was discussed.
Fine Structural Alteration of Pancreas and Effect of Vitamin E in Acute Hypovolemic Shock
Lee, Hai Koo,Chun, Yong Hyuck,Rha, Bok Young 고려대학교 의과대학 1979 고려대 의대 잡지 Vol.16 No.1
Shock가 膵臟의 微細構造에 미치는 變化와 이때 Vitamin E의 影響을 追求하고저 體重 170~190gm의 成熟雄性白鼠 24마리를 3群으로 나누어 正常對照群과 實驗群으로 하고 그 中 한 群에는 dl-alpha-tocopherol acetate를 1日 30㎎式 10日間 腹腔內 注射하였다. 麻醉自體가 주는 變化를 排除하고저 各群의 半數는 pentobarbital sodium으로 麻醉한 狀態에서 正常對照群을 除外한 두 實驗群 動物들은 各己 左心室에서 4~5cc의 血液을 急速히 採血함으로서 失血性 shock 狀態로 誘導되었고 卽時 開腹, 膵臟을 切除, 式에 따라 glutaraldehyde 및 osmium tetroxide에 固定하고 epon 混合液이 包埋한 후 超薄片을 製作, uranyl acetate-lead citrate 染色後 電子顯微鏡으로 觀察하여 다음과 같은 所見을 얻었다. 1. 急性 失血性 shock는 腺胞 및 島細胞들의 絲粒體의 融解性變化를 誘發하였고 血管주위 腺胞細胞의 顆粒性內形質細網의 擴張을 招來하였다. 이러한 變化는 dark cell에서는 light cell보다 훨씬 輕微하였다. 2. Vitamin E 投與는 失血로 因해 惹起되는 變化를 거의 完全히 防止하였고 腺胞細胞의 合性機能을 促進하는 것 같이 보였다. 3. Pentobarbital sodium 全身麻醉로 인한 膵臟微細構造의 變化는 볼 수 없었다.