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Salmonella enteritidis와 S. typhimurium의 invasion 유전자 invH, invF, hilA의 클로닝과 유전적 분석
홍지애 ( Ji Ae Hong ),김진우 ( Jin Woo Kim ),나훈택 ( Hoon Taek Na ),김수영 ( Soo Young Kim ) 한국자연치유학회 2015 Journal of Naturopathy Vol.4 No.1
In this study, a gene sequence was determined after cloning genes invH, invF and hilA from Salmonella enterica subsp. enterica, serovar typhimurium and enteritidis. Genes were identified using electrophoresis after being PCR conducted. The result of comparison of determined gene sequence with Salmonella typhimurium LT2 and S. enterica U84273.1 (S. enterica subsp. enterica) showed highly correlated characteristics, i.e,. 99% for invH gene, and 100% for genes invF and hilA, respectively. Finally, in this study was formed a library of invasion, which is known as a toxicity factor of Salmonella, and determined the candidate genes of Salmonella epitope necessary for the production of the oral vaccine.
구본철(Boncheol-Leo Goo),송다혜(Da-Hye Song),최유진(Yu-Jin Choi),오교녀(Kyo-nyeo Oh),오둘리(Dool-Ri Oh),홍지애(Ji-Ae Hong),김은정(Eun-Joung Kim) 한국생약학회 2023 생약학회지 Vol.54 No.4
Skin aging is caused by structural changes in the extracellular matrix (ECM) due to internal and external factors. It is characterized by decreased skin moisture, increased skin roughness, increased skin wrinkles, and decreased skin elasticity. In this study, Elastase and Collagenase inhibitory activities and SOD, CAT, and GSH-Px activities were confirmed in HaCaT cells, and Collagen-I content and skin elasticity were also confirmed in response to UVB irradiation in HR-1 hairless mice. In addition, a double-blind, randomized, placebo-controlled study was conducted on the effects of oral administration of NP-2007 in 84 women. In the group that consumed NP-2007 or placebo, the amount of skin moisture, trans-epidermal water loss (TEWL), mass of skin keratin, skin asperity (Ra, Rz), eye wrinkle, and skin elasticity were checked. Compared to the placebo group, significant changes were confirmed at all-time points after 6 and 12 weeks of intake. This study was investigated the potential of oral administration of NP-2007 as a functional food material that improves skin.