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온도 감응성 MPEG-PCL 하이드로젤을 이용한 단백질의 서방화
서광수 ( Kwang Su Seo ),홍금덕 ( Keum Duck Hong ),현훈 ( Hoon Hyun ),김문석 ( Moon Suk Kim ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.2
The temperature sensitive hydrogels were synthesized by the terminal alcohol of methoxy poly(ethyleneglycol) (MPEG) as an initiator via ring-opening of ε-caprolactone (ε-CL) in the presence of HCl·Et2O as a monomer activator. The gel-to-sol transitions of MPEG-PCL diblock copolymer solutions were also examined in deionized water according to polymer concentration. The MPEG-PCL block copolymers were dissolved in water at 80oC and stored at 4oC for 15 hours. The polymer solutions formed sol around at the room temperature. The formed sol became gel from 31oC to 53oC by increasing the temperature. To observe the release behavior of protein based on MPEG-PCL block copolymers, hydrogels loaded proteins such as albumin, insulin, and dextran were easily fabricated by mixing polymer solution and proteins. The release profile of proteins in MPEG-PCL hydrogels showed the sustained zero-order release without initial burst for 20 days. In conclusion, we confirmed that MPEG-PCL temperature sensitive hydrogels is useful as controlled protein carriers.
아시클로비어와 수용성 고분자를 이용한 고체분산체 제조 및 생체외 방출
안용산,이하영,홍금덕,정성범,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3
Acyclovir(ACV) is an important antiviral drug used extensively against infections caused by herpes viruses, especially herpes simplex and varicella zoster. Because of high crystallinity and large particle size, solubility of intact ACV is very low in water(1.3 ㎎/㎖). The goal of this work is to enhance the solubility of ACV. To make solid dispersion, Polyethyleneglycol. Hydroxyprophylmethyleelluose and Polyvinylpyrrolidone were used as polymer carriers in this work. Polymer carriers and drug were dissolved in acetic acid. And then spray drying method and freeze drying method were used as solvent extraction. Morphology, crystallization and functional group were characterized using SEM. XRD and ET-IR. The result of in vitro test showed the sample using PVP as polymer carrier had higher dissolution rate(up to 466%) than intact ACV.
아시클로비어 고체분산체의 용해도에 대한 수용성 고분자의 종류 및 배합 비율에 따른 효과
안용산,이하영,홍금덕,정성범,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in 80°C distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.