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- 저자 : 한광혀(Swang Hyub Han) (검색결과 1 건)
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강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myung Moon),정재복(Jae Bock Chung),이상인(Sang In Lee),전재윤(Chae Yoon Chon),김상애(Sang Ae Kim),함기백(Ki Back ham),한광혀(Swang Hyub Han) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A For the evaluation of clinical efficacy of famotidine, a new, potent, long-acting histamine H2-receptor antagonist, in patients with gastric and duodenal ulcer, 42patients with endoscopically-proved active gastric ulcer (19 patients) and duodenal ulcer (23 patients) were admitted to this trial. Thirty two patients were treated with famotidine 20 mg b.i.d. and 10 with cimetidine 200 mg q.i.d. up to 8 weeks. The observed results were as follows: 1) The complete healing rates of gastric ulcer by endoscopic examination at 4,6 and 8 weeks were 50.0%, 68.8% and 93.8% in famotidine group, and 33.3%, 66.7% and 100.0% in cimetidine group, respectively. 2) The complete healing rates of duodenal ulcer by endoscopic examination at 4, 6 and 8 weeks were 62.5%, 81.3% and 100.0% in famotidine group, and 57.1%, 71.4% and 85.7% in cimetidine group, respectively. 3) Abnormal laboratory finding after treatment was found only in one case in famotidine group, but 3 cases in cimetidine group. 4) There was no significant difference in symptomatic improvement between two groups and mild side effects were complained of in 5 of 32 famotidine group (15.6%) and 4 of 10 cimetidine group (40. 0%). In conclusion, data from the present ivestigation suggest that Famotidine is effective in the treatment of gastric and duodenal ulcer, and is well tolerated on a short-term basis. Further and more extensive studies are necessary to confirm these findings.
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