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동충하초에서 분리된 신규 항암물질의 효율적 합성법 개발
차해연(Haiyan Che),트루옹 넉 투엔(Ngoc Tuyen Truong),윤덕효(Deok Hyo Yoon),김태웅(Tae Woong Kim),성기호(Gi-Ho Sung),박해일(Haeil Park) 대한약학회 2012 약학회지 Vol.56 No.2
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.