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동충하초에서 분리된 신규 항암물질의 효율적 합성법 개발
차해연(Haiyan Che),트루옹 넉 투엔(Ngoc Tuyen Truong),윤덕효(Deok Hyo Yoon),김태웅(Tae Woong Kim),성기호(Gi-Ho Sung),박해일(Haeil Park) 대한약학회 2012 약학회지 Vol.56 No.2
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.
차해연(Haiyan Che),윤덕효(Deok Hyo Yoon),김태웅(Tae Woong Kim),성기호(Gi-Ho Sung),박해일(Haeil Park) 대한약학회 2012 약학회지 Vol.56 No.6
Militarin was isolated from Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom and reported to possess anticancer activities against several tumor cells. A number of militarin derivatives bearing different numbers of ethylene glycol unit were synthesized and evaluated for their biological activities related with anticancer and antiinflammatory effects. Among militarin derivatives tested, the compounds 2 and 5 exhibited anticancer and antiinflammatory activities.
헤테로 고리를 갖는 크리신 유도체의 합성 및 항염증 작용에 대한 평가
차해연(Haiyan Che),트루옹넉투엔(Ngoc Tuyen Truong),김현표(Hyun Pyo Kim),박해일(Haeil Park) 대한약학회 2011 약학회지 Vol.55 No.6
Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6- dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE2 and NO production than those of chrysin.