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Protein-based nanocomplexation and its implications on biological activity
최신식 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Phenolic compounds have been widely used as functional foods, nutritional supplement and herbal medicine in many countries for a while.In recent years, extensive studies have investigated their beneficial functional properties including antioxidant, anticancer, anti-inflammatory,antimicrobial, wound healing and potential prevention ability of neurodegenerative diseases. However, poor bioavailability caused by its lower aqueous solubility and stability is considered as a major barrier for its fortification into food or pharmaceutical products. In this study,we fabricated phytochemical-protein nanocomplexes to improve its stability and bioavailability. As a result, nanocomplexes of phytochemicals were formed with ovalbumin, a predominant protein in egg white mainly through hydrophobic intermolecular interactions. Spectroscopic studies also revealed that about 90% of phytochemicals remained stable after 10 hours of incubation, which would be sufficient time for its intestinal absorption and conferring its maximum medicinal functionalities.