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문신용(Shin Yong Moon),김석현(Seok Hyun Kim),지병철(Byung Chul Gee),성기청(Ki Cheong Sung),최성미(Sung Mi Choi),김희선(Hee Sun Kim),오선경(Sun Kyung Oh),서창석(Chang Suk Suh),최영민(Young Min Choi),김정구(Jung Gu Kim),이진용(Jin Yong 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : To establish the optimal cryopreservation method in mouse oocytes. Methods : Firstly, mouse immature oocytes were exposed to various cryoprotectants, and then cryoprotectant with the best outcome was selected. Secondly, mouse immature oocytes were cryopreserved by either slow freezing and ultra-rapid thawing or vitrification. Finally, in mouse mature oocytes, the five different protocols were compared in their fertilization and hatching rates. Results : 1) 1.5M 1,2-propanediol (PROH) and 1.5M PROH+0.1M sucrose had a higher rate of survival (73.1%, 81.9%) and in vitro maturation (28.2%, 30.1%). 2) Vitrification using 5.5M ethylene glycol (EG) showed significantly higher rate of survival and in vitro maturation, when compared with slow freezing and ultra-rapid thawing using 1.5M PROH+0.1M sucrose (65.9% vs 50.0%, 40.0% vs 28.2%, respectively). 3) In mouse mature oocytes, vitrification using 5.5M EG showed significantly higher survival rate, however, slow freezing and ultra-rapid thawing using 1.5M DMSO was superior to vitrification in view of fertilization rate. Conclusions : Vitrification showed better outcomes in mouse immature oocytes, but slow freezing and ultra-rapid thawing using 1.5M DMSO may be beneficial in mature oocytes.
폐경 여성에서 기저 골밀도에 따른 호르몬 대체요법에 대한 골반응성
김정구(Jung Gu Kim),김광례(Kwang Rai Kim),지병철(Byung Chul Gee),김석현(Seok Hyun Kim),최영민(Young Min Choi),문신용(Shin Yong Moon),이진용(Jin Yong Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : To investigate the incidence of non-responder to hormone replacement therapy (HRT) and to evaluate the bone response to HRT according to basal bone mineral density(BMD) in postmenopausal women. Methods : A total of 211 postmenopausal women received either continuous combined estrogen- progestogen replacement (n=112) or estrogen replacement (n=99) for 1 years. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (DEXA) before and 1 year after HRT. Results : The incidence of non-responder (women with > 3% bone loss per year) to HRT was 9.2% in the lumbar spine, and 23.8% in femoral neck. Estrogen replacement group had a higher incidence of non-responder than combined replacement group. Non-responder group had a higher basal BMD at the lumbar spine than responder group, and showed bone loss rate of 7.6% per year. After 1 year of HRT, postmenopausal women with osteoporosis showed a higher rate of increase in BMD at the lumbar sine and femoral neck than women with normal BMD or osteopenia. Conclusion : The non-responders to HRT have a higher basal lumbar BMD, compared with responders. The higher basal BMD at the lumbar spine is, the less bone conservation effect of HRT is.