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주인호,우종표 한국유화학회 2004 한국응용과학기술학회지 Vol.21 No.2
Film forming behavior of monodispersed model composite latexes with particle size of 190 ㎚, which consist of n-butyl acrylate as a soft phase monomer and methyl methacrylate as a hard phase monomer with different morphology was examined. Five different types of model latexes were used in this study such as random copolymer particle, soft-core/hard-shell particle, hard-core/soft-shell particle, gradient type particle, and mixed type particle. The film forming behavior was evaluated using pseudo on-line measurements of the cumulative weight loss, the UV transmittance, and the tensile fracture energy. Each stages of film formation Ⅰ, Ⅱ were not sensitive to the morphology of model latexes, but stage-Ⅲ was largely dependent on the morphology of model latexes. The chain mobility of polymer which composed the shell component was found to dominantly determine the behavior of film forming stage-Ⅲ.
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주인호,진상화,배기범,신진용,최창수,최수임,홍관희 대한대장항문학회 2008 Annals of Coloproctolgy Vol.24 No.4
Purpose: Because depth of invasion by T3 rectal cancer can vary according to the extent of mesorectal invasion, the prognosis for invasive T3 rectal cancer is reported to be very different from that for minimal invasive cancer. Recently, with more emphasis on circumferential resection margin (CRM) status, the T stage, rather than the N stage, seems to be a more valuable prognostic marker in rectal cancer. Therefore, the aim of this study is to determine the prognostic significance of the CRM in invasive T3 rectal cancer. Methods: Through reviewing 324 consecutive patients with rectal cancer who underwent a curative resection between January 1995 and December 2002 at Busan Paik hospital, 195 patients with invasive T3 rectal cancer, who had not received preoperative neoadjuvant therapy were selected. The patients were classified into a negative CRM group (negative group, n=173) or a positive CRM group (positive group, n=22), and the patients were subgrouped according to the presence of lymph-node (LN) metastasis and CRM status as negative LN and negative CRM (L−/CM−), negative LN and positive CRM (L−/CM+), positive LN and negative CRM (L+/CM−) and positive LN and positive CRM (L+/CM+). All pathological specimens were re-reviewed by a single pathologist, and the distance between the most advanced edge and the outermost aspect of the specimen was re-measured by using a microscope. Local relapse rates, disease free survival, and overall survival were compared using the Kaplan- Meier method. Multivariate analyses to identify independent prognostic factors were performed using the logistic regression model. Results: Local recurrence rates in the positive group and the negative group were 38.6% and 15.3%, respectively (P=0.004, log-rank test). The multiple logistic regression model demonstrated positive CRM (hazard ratio 4.4, P=0.0007) and N2 nodal status (hazard ratio 2.4, P=0.02) as predictors of local recurrence. In the subgroup analysis, the overall recurrence rates and survival rates were, respectively, 12.3% and 86.5% in the L−/CM− subgroup, 53.1% and 50.3% in the L−/CM+ subgroup, 52.7% and 50.0% in the L+/ CM− subgroup, and 58.7 % and 33.8% in the L+/CM+ subgroup (log rank test for trend; P=0.0001 and P=0.0001, respectively). Conclusions: In the event of predicted CRM involvement in invasive T3 rectal cancer, adjuvant therapy should be performed to improve local control. Also, larger prospective studies are needed to clarify the prognostic role of the CRM in invasive T3 rectal cancer because the number of cases in this study was small, especially in the number of CRM positive cases.
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