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RISS 인기검색어
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- 저자 : 조성옥(S O Cho) (검색결과 3 건)
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원발성 간암의 종양 표식자로서 DNase 와 Rnase 에 관한 연구
기춘석(Chun Suk Ki),신봉재(B J Shin),조성옥(S O Cho),한중수(J S Han),고재경(J K Koh) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A Activities of acid deoxyribonuclease (DNase) and neutral ribonuclease (RNase) in liver tissue, serum and ascitic fluid and urinary excretion of the modified ribonucleosides were determined in patients with hepatocellular carcinoma (15 cases) and liver cirrhosis (18 cases) hospitalized in the department of internal medicine of Hanyang University Hospital. Comparing these results with those obtained from normal healthy persons (20 cases), the present study pursued whether these parameters could be used as diagnostic and biochemical markers for hepatocellular carcinoma. 1) Serum neutral RNase activity was unchanged in liver cirrhosis, but increased in hepatocellular carcinoma by 70% and the positive rate of the serum enzyme as a marker for hepatocellular carcinoma was 60%. 2) Ascitic fluid neutral RNase activity was increased in hepatocellular carcinoma by 54% as compared with that of liver cirrhosis, and the positive rate of the ascitic fluid enzyme as a marker for hepatocellular carcinoma was 67%. Rnases and proteins in ascitic fluid of hepatocellular carcinoma were isolated by a DEAE-cellulose column chromatography into 5 peaks each, of which two peak proteins and RNases appeared to be unique to the cancer. 3) Liver acid Dnase activity was unchanged in liver cirrhosis, but increased greatly in hepatocellular carcinoma (117% increase), and the positive rate of the liver enzyme as a marker for hepatocellular cancer was 80%. The present study indicate that serum and ascitic fluid RNase activity, liver acid Dnase activity and urinary excretion of modified ribonuclesides can be used for diagnostic and biochemical markers for hepatocellular carcinoma. The combined use of these parameters might be useful for making accurate diagnosis for hepatocellular carcinoma.
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금동인,조성옥 대한신경외과학회 1976 Journal of Korean neurosurgical society Vol.5 No.1
Cerebral cysticercosis is, unfortunately, a frequent disease in Korea. Cysts in the ventricular system are rarest form. They are most frequently observed in the fourth ventricle, more rarely in the lateral and third ventricles. The clinical picture of ventricular cysticercosis is that of increased intracranial pressure with hydrocephalus. Of the surgical interventions of cerebral cysticercosis most favorable result can be expected in this variety. Two cases of cysticercosis in the fourth ventricle were reported. Neither case had the hx. of T. Solium infestation nor typical blood and C.S.F. picture. The clinical picture was that of increased intracranial pressure with occasinal sudden hydrocephalic attack which usually lasted 24 hrs. The first case died abruptly because of sudden respiratory arrest.
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금동인,백지현,조성옥 대한신경외과학회 1977 Journal of Korean neurosurgical society Vol.6 No.2
Approximately 4% of cerebral aneurysms are of mycotic origin. The desination of "mycotic" for arterial lesions of infectious origin was provided by Osier in 1885, and. The relationship of mycotic aneurysms in any location to bacterial endocarditis was made clear by the review of Stengel and Wolferth in 1923. Mycotic aneurysms are abnormalities of the vessel wall resulting from infacted emboli, most commonly arising from the heart as a part of the spectrum of bacterial endocarditis. The middle cerebral artery is most commonly involved, including its proximal division which is a common site for congenital aneurysms also. Recently we experienced a case of middle cerebral mycotic anenrysm ruptured into the lateral ventricle and sucessful removal of the hematoma after clipping of the aneurysm. The patient was discharged uneventhly in mild left hemiplegias we discussed with a brief review of the literature.
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