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비상품 양파추출물의 Mouse 피부암 및 위장암 억제효과
이찬중(Chan-Jung Lee),김희대(Hee-Dae Kim),정은호(Eun-Ho Choung),서전규(Jun-Kyu Suh),박철우(Cherl-Woo Park),하영래(Yeong-Lae Ha) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.3
상품가치가 없는 비상품구로부터 추출한 OWE를 mouse의 피부암 및 위장암 저해 효과에 관한 실험을 한 결과 피부암의 경우 control구에서는 6주부터 종양이 발생하여 23주에는 mouse 당 2.9개의 종양이 발생하였으나, 20 mg OWE 처리구에서는 8주부터 종양이 발생하여 23주에는 mouse 당 1.3개의 종양이 발생하여 control에 비해 55.2%의 종양 억제효과가 있었다. 20 mg quercetin 처리에서는 6주부터 종양이 발생하기 시작하여 23주에는 mouse 당 1.2개의 종양이 발생하였다. 처리별 암 발생율은 20 mg OWE 처리에서 85.7%, 20 mg quercetin처리에서는 76.2%의 발생율을 보여 control의 95.2%에 비해 낮은 암발생율을 보였다. 위장암의 경우 control에서는 mouse당 9.2개의 종양이 발생하였고, 50 mg OWE 및 25 mg OWE 처리에서는 각 6.1, 6.3개의 종양이 발생하여 control에 비해 각각 33.7%, 31.5%의 종양억제효과가 있었다. 그리고 25 mg quercetin처리에서는 mouse 당 5.3개의 종양이 발생하였다. 처리별 암발생율은 50 mg OWE 및 25 mg OWE 처리에서 각 88.2%, 94.1%, 25 mg quercetin처리에서 83.3%의 발생율을 보여 control 100%에 비해 낮은 암발생율을 보였다. Effect of the onion waste extract (OWE) on chemical carcinogen-induced mouse epidermal and forestomach carcinogenesis was investigated. Female ICR mice (6~7 weeks of age) were adapted in a temperature- and humidity-controlled house for one week. In a epidermal carcinogenesis model, animals were randomly divided into 3 treatment groups (7 mice/cage, 21 mice/treatment group). Back of the mouse was shaved 10 days before 7,12-dimethylbenz[a]anthracene (DMBA) treatment. OWE (20 mg/0.2 mL acetone) or quercetin (20 mg/0.2 mL acetone) was painted on the back of the mouse on 7th-days, 3th-days and 5-min before the initiation of carcinogenesis with DMBA (50 nmole/0.2 mL acetone). Control mice were received only 0.2 mL acetone. From one week after the initiation, each mouse received twice weekly injection of phorbol 12-myristate 13-O-acetate (TPA: 6 μg/0.2 mL acetate) until the termination of experiment (23 weeks). In forestomach carcinogenesis model, female ICR mice (6~7 weeks of age, 10 mice/cage, 20 mice/treatment group) was randomly divided into 4 treatment groups: 50 mg and 25 mg OWE/0.2 mL soybean oil, 25 mg quercetin/0.2 mL soybean oil, and 0.2 mL soybean oil only. Mouse received sample through garbage on Monday and Wednesday, and benzo[a]pyrene (BP) (2 mg/0.2 mL soybean oil). This treatment process was repeated for 4 weeks. Control mice received soybean oil only. In the case of epidermal carcinogenesis, OWE treatment (1.3 tumors/mouse) reduced the number of tumors per mouse, relative to that of the control (2.9 tumors/mouse), but similar to that of quercetin treatment (1.2/mouse). The tumor incidence (85.7%) in mouse treated with OWE was slightly reduced as compared to that (95.2%) of the control, and slightly higher than that (76.2%) of quercetin treatment group. OWE treatments (50 mg and 25 mg) reduced the number of forestomach tumors per mouse to 33.7% and 31.5% of the control, respectively. However no difference was observed from quercetin treated mouse. Forestomach tumor incidence was also reduced from 100% (control) to 88.2% (50 mg OWE) and 94.1% (25 mg OWE). The tumor incidence of 50 mg OWE was similar to that (83.3%) of 25 mg quercetin treatment. These results indicate that OWE inhibited the initiation of epidermal and gastric carcinogenesis in mice, and the effective dose was similar to quercetin.
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