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RISS 인기검색어
- 검색키워드
- 저자 : 정병수 ( Moon Hee Hong (검색결과 4 건)
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정병수,홍문희,김영균 ( Byoung Soo Chung,Moon Hee Hong,Young Kyun Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6
Trichonodosis(knotted hair) is a disorder of the hair shaft that can comprise a single or double knot. Reports of trichonodosis are not cornmon in dermatological literature, but it is generally considered not to be rare. Two varieties of trichonodosis have been described. A rare type occurs in association with abnormally growing scalp and body hair that tends to splinter and fracture. A more comrnon form occurs when normal hair is subjected to rnechanical forces, such as combing and brushing. Trichonodosis occurs exclusively in persons with curly or kinky hair. We report a patient with short, straight hair and trichonodosis. The most likely cause in our patient is trauma as a result of continual rubbing of hairs. (Korean J Dermatol 1997;35(6): 1241-1243)
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진피내 멜라닌세포성 병변에서 Integrin 표현과 아포프토시스 세포에 관한 연구
홍문희 ( Moon Hee Hong ),정병수 ( Byound Soo Chung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Background: Many mammals normally have a population of dermal melanocytes but these are not found in man, In humans, persistent dermal melanocytes can occur in the Mongolian spot, the nevus of Ota, and the blue nevus. Mongolian spot develops in the fetal or neonatal time and disapperars almost invariably during childhood. In contrast, nevus of Ota and blue nevus are not usually present at birth and persists in adult life. Recently, it was established that apoptosis can be involved in the development of melanocytes. The integrins mediate cell-cell and cell-matrix interactions, and apoptosis can be induced by disruption of cell-matrix interactions. Objective : The purpose of this study was to investigate the expression of integrins (a2 , a3 , ar) and in situ detection of fragmented DNA in Mongolian spot, nevus of Ota, and blue nevus. Methods : Formalin-fixed and paraffin-embedded tissues from 8 cases of Monglian spot, 5 cases of nevus of Ota, and 4 cases of blue nevus were immunolabelled with monoclonal antibodies TM directed against az, ay, and av integrin, and stained with ApopTag in situ using an Apoptosis Detection kit. The cases of Mongolian spot were divided into two groups in which group A represented the the cases of more than 45 melanocytes and group B represented the cases of less than 10 melanocytes in a tissue section of 4-mm taken from punch biopsy specimens. Results: Blue nevi showed az and e integrin expressions in dermal melanocytes and weak to negative staining of g v integrin in comparison with all positive expressions of a z, a s, and g y integrin in A group-Mongolian spots and nevi of Ota. The B group-Mongo]ian spots showed the continuous expressions of a z and a y integrin with negative expressions of a v integrin. The ApopTag kit staining was all negative in the Mongolian spots, nevi of Ota, and blue nevi. Conclusion . Our results support the view that dermal melanocytic tumors, such as the Mongolian spot, the nevus of Ota, and the blue nevus, might be induced by the disturbance or inhibition of the apoptotic process of the melanocytes, and that the spontaneous disappearance of the Mongolian spot may not be related to the apoptosis. (Korean J Dermatol 1998;36(1): 52-58)
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홍문희,한경표,정병수 ( Moon Hee Hong,Kyoung Pyo Han,Byoung Soo Chung ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Clinically adult-onset xanthogranuloma is somewhat different to that of juvenile xanthogranuloma. There seems to be no definitive sites of predilection and concomitant extracutaneous lesions, and spontaneous resolution does not occur in the adult form. The lesions of the adult form are usually asymmetric or solitary. We describe an adult with a solitary xanthogranuloma on the left shoulder. Histological findings of this case show minor differences from juvenile xanthogranuloma but immunohistochemical findings were very similar to those of juvenile xanthogranuloma. (Kor J Dermatol 1997;35(4): 786-789)
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