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가토에서 생검총을 이용한 간생검후 충전 물질에 관한 실험적 연구 : 젤폼, 섬유소밀봉제(Fibrin Sealant) 및 NBCA의 비교
곽병국,정걸호,최치훈,윤혜란,박용옥,이창준,김희곤,장희진,심형진 대한영상의학회 1998 대한영상의학회지 Vol.39 No.1
Purpose : To evaluate the effect of plugging the biopsy tract in rabbit liver and the pathologic changes caused by plugging materials. Materials and Methods : Thirty-two New Zealand White rabbits were divided into four groups(eight rabbits in each) and compared with one another. They were labeled group A(control), B(gelfoam), C(fibrin sealant) or D(NBCA). The liver was exposed and biopsied with an 18G disposible biopsy gun. The inner Tru-cut needle was withdrawn and plugging was undertaken through the outer cannula of the biopsy gun. Bleeding times of each material were compared. The rabbits were sacrificed and pathologically evaluated for 17 days. Results : Mean bleeding times were 46.7$\pm$34.5 sec in group A, 42.9$\pm$54.7 sec in group B, 12.6$\pm$15.0 sec in group C, and 0 sec in group D. In groups C and D, these results were statistically significant(p<0.01). Pathologically, fibrin sealant was lowest in foreign body reaction and fibrosis. NBCA was effective for the prevention of hemorrhage. Conclusion : NBCA and fibrin sealant effectively plug the biopsy tract through the outer cannula of an18 G biopsy gun.
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가토에서 생검총을 이용한 폐생검후 NBCA 충전에 관한 실험적 연구 : 가토폐 생검 후 NBCA 충전
곽병국,정걸호,최치훈,이창준,장희진,심형진 중앙대학교 의과대학 의과학연구소 1999 中央醫大誌 Vol.24 No.1
Pneumothorax and hemorrhage are frequent complications after percutaneous lung biopsy. The purpose of this study is to evaluate the effects of NBCA on plugging the biopsy tract in rabbit lung and pathologic changes caused by NBCA. The right lungs of 14 New Zealand White rabbit were biopsied with an 18G biopsy gun. The biopsy tracts were filled with none(control group) and NBCA mixed with lipiodol(1:1) in 7 rabbits respectively. CT scans were performed immediatoly and 24 hours after procadure. The rabbits were sacrificed and pathologically cvaluated for 17 days. Each pneumothorax and pulmonary heomrrhage as a complication after gun biopsy was seen in 4 cases (57.1%) of the control group(n=7). In NBCA group(n=7), pneumothorax was seen in 2 cases(28.6%) and hemorrhage was seen in 1 case(14.3%)(p>0.05). NBCA filled the biopsy tract and pleural space, and pleural adhesion was seen in 1 case of 2 rabbits complicated by pneumothorax. Pathologically the hemorrhage was more significant in control group(100%) than in NBCA group(28.6%). But the inflammation was 28.6% in control group and 100% in NBCA group. The necrosis, foreign body reaction and fibrosis were similar in both groups. In conclusion, NBCA would be helpful to prevent the pneumothorax and hemorrhage after a percutaneous lung biopsy.
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