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RISS 인기검색어
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- 저자 : 전인주(In Ju Chon) (검색결과 3 건)
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전인주(In Ju Chon),이성환(Seong Wan Lee),차자현(Ja Hyun Cha),한정훈(Jeong Hoon Han),황완균(Wan Kyunn Whang) 대한약학회 2005 약학회지 Vol.49 No.5
Cudrania tricuspidata Bereau (Moraceae) have been used for anti-inflammatory, anti-hepatotoxic, anti-hypertensive and anti-diabetic activities. In order to investigate the efficacy of antioxidant activity, the bio-activity guided fraction and isolation of Biologically active substance were performed. H2O, 30%, 60%, 100% MeOH and acetone fractions were examined on the antioxidant activity by DPPH method. It was shown that 30%, 60%, 100% MeOH fractions have significantly antioxidant activity. From 30% MeOH fraction, two dihydroflavonoid glycosides dihydroquercetin 7-O-β-D-glucopyranoside (I), dihydrokaempferol 7-O-β-D-glucopyranoside (V) were isolated and 60% MeOH fraction, six flavonoids including quercetin 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (Ⅱ), quercetin 3-O-β-D-glucopyranoside (Ⅲ), quercetin 7-O-β-D-glucopyranoside (Ⅳ), kaempferol 3-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (Ⅵ), kaempferol 3-O-β-D-glucopyranoside (Ⅶ), kaempferol 7-O-β-D-glucopyranoside (Ⅷ) were isolated. To investigate the antioxidant activities of each compounds, we measured radical scavening activity with DPPH method and anti-lipid peroxidative efficacy on low density lipoprotein (LDL) with TBARS assay. Four compounds of quercetin glycosides (Ⅰ,Ⅱ,Ⅲ,Ⅳ) showed significant antioxidant activity.
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전인주,김호현,김진표,함인혜,최용주,이상대,성환길,황완균 중앙대학교 약학연구소 2003 약학 논총 Vol.17 No.-
This studies were attempted to evaluate the antioxidant and the antidiabetive activities of Phellinus linteus and its preparation. The DPPH was revealed that Phellinus linteus and Allium cepae bulbus mixture had significantly antioxidant activity. TEARS assay showed that Phellinus linteus and Houttuyniae herbal mixture and Phellinus linteus and Ginseng radix rubra 'mixture had significantly anti-lipid peroxidative efficacy when compared to that of contrast drug, ascorbic acid. The effect of Phellinus linteus and its preparation on Diabetic animal model were investigated in streptozotocin-induced diabetic SD rats. The blood glucose was dose-dependently decreased when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra mixture was administrated significantly. The serum total cholesterol was showed inhibitive activity when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra 'mixture was administrated. Especially 200 ㎎/㎏ fraction was dose-dependently decreased. The serum triglyceride hyperglycemic rats was dose-dependently decreased when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra mixture was administrated. But when Phellinus linteus and Allium cepae bulbus mixture and Phellinus linteus and Houttuyniae herbal mixture increased dose, the serum total cholesterol and the serum triglyceride hyperglycemic rats were increased too.
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기능성 식품 복합처방을 이용한 항산화 및 항염증제 개발
조형권,김진표,전인주,함인혜,황완균 중앙대학교 약학연구소 2003 약학 논총 Vol.17 No.-
To investigate the antioxidant activitys of Biofuntional Foods Prescriptions(BFP), we were measured radical scavenging activity with DPPH method and anti-lipid peroxidative efficacy on human LDL with TBARS assay. The DPPH was revealed that Two BFP have siginificantly antioxidant activity. But, TBARS assay showed that Rx B which was signifacantly antioxidant activity had lower anti-lipid peroxidative efficacy when compared to that of contrast drug, ascorbic acid. The anti-inflammatory potential of ethanol exracts of Rx B was evaulated against model of inflammation such as carragenin induced paw edema in rats. 100㎎/㎏, 200㎎/㎏, and 400㎎/㎏ fractions of Rx B showed 20.95%, 12.56%. 18.95% when compared to that of control animals at one hour after oral administration. The effect was comparable with that of the standard drug indomethacin, a standard non-steroidal anti-inflammatory drug. Inhibition rates of each fraction showed a few lower than that of standard drug, indomethacin. At two, three, four hour after oral administration, 100㎎/㎏ fraction showed 26.9.3%, 33.73%, 21.4%, 200㎎/㎏ fraction showed 20.4%, 22.99%, 15.24%, and 400㎎/㎏ fraction showed 21.43%, 21.30%, 10.85%. Inhibition rates of each fractions were significantly reduced when compared to that of the standard drug indomethacin that showed 27.79%, 35.81%, 22.40% at two, three, four hour after oral administration
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