당귀수산(當歸鬚散)이 대퇴골절 유발 생쥐에 미치는 영향

전동휘 ( Dong-hwi Jeon ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.1

Objectives This study was designed to evaluate the effects of Danggwisu-san (Dangguixu-san, DG) on bone repair from femur fracture in mice. Methods Mice were randomly divided into 4 groups (normal, control, positive control and DG 300 mg/kg-treated group). In order to investigate the effects of DG on gene expressions in experimental animals with fracture, we measured the levels of bone morphogenetic protein-2 (BMP2), cyclooxygenase-2 (COX2), Sox9, collagen type Ⅱ alpha 1 chain (Col2a1), runt-related transcription factor 2 (Runx2), osterix genes. After the cytotoxicity test, we analyzed the levels of expression of osteocalcin and Runx2, and tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine. The process of fusion in the fracture was also investigated by gross examination. Results Through in vivo BMP2, COX2 gene expression significantly decreased. Sox9 significantly increased. Col2a1, Runx2, osterix gene expression also increased as well, but there was no statistical significance. The degree of unilateral fracture fusion investigated by gross examination was significantly faster than those of the other groups. Through in vitro the level of TNF-α in macrophages was increased by DG in a dose-dependent mannerand and 250 and 500 μg/mL showed statistical significance. Osteocalcin and Runx2 genes expressions increased when DG was treated in osteoblasts. Conclusions DG promotes the healing of the fracture through the expression of bone repair-related genes and TNF-α production. This study may set the foundation for the clinical application of DG to the patients with bone fractures. (J Korean Med Rehabil 2021;31(1):1-16)

퇴행성무릎관절염 변증도구 개발에 관한 기초연구

전동휘 ( Dong Hwi Jeon ),이은정 ( Eun Jung Lee ),소현우 ( Hyun Woo So ),황만석 ( Man Suk Hwang ),유정은 ( Jeong Eun Yoo ),박양춘 ( Yang Chun Park ),정인철 ( In Chul Jung ),오민석 ( Min Seok Oh ) 대한한의학회 한방재활의학과학회 2017 한방재활의학과학회지 Vol.27 No.2

Objectives The aim of this study was to develop a standard tool of pattern identification for Knee Osteoarthritis, which will be applied to clinical research. Methods The advisor committee for this study was organized by 11 panel of experts (Korean Rehabilitation Medicine professors, Acupuncture and Moxibustion professors belonging to Korean Medicine colleges, Principal Researcher of Korea Institute of Oriental Medicine, Doctor of Korean medicine). The pattern identifications and symptoms for this tool were extracted from published Korean and Chinese literature. Through the discussion among internal experts and consultation from advisors, the Instrument on Pattern Identifications for Knee Osteoarthritis was developed. Results 1) Five pattern identifications (The Wind, Chill, and Moisture, The Moist-Heat, Blood Stasis, Yang Deficiency of Spleen and Kidney, Yin Deficiency of Liver and Kidney) were set for the tool. 2) The mean weights which represent the importance of each symptom and scored on a hundred-point scale was obtained. 3) The Instrument on Pattern Identifications for Knee Osteoarthritis was designed in the self-reporting format composed of 46 questions. Conclusions The Instrument on Pattern Identifications for Knee Osteoarthritis was created through this study. Though this study is not proved about validity, reliability, the instrument of pattern identification for Knee Osteoarthritis is meaningful and expected to be applied to the subsequent. (J Korean Med Rehabil 2017;27(2):77-91)

교통사고 환자의 심신의학적 접근에 대한 국내연구동향 고찰-2000년도이후 국내학술지 중심으로-

전동휘(Dong Hwi Jeon),이치호(Chi ho Lee),정훈(Hoon Jung),김윤주(Yun Joo Kim),이은정(Eun Jung Lee),오민석(Min-Seok Oh) 대한스포츠한의학회 2016 대한스포츠한의학회지 Vol.15 No.2

Objectives The aim of this review is to analyze research trends of the mind-body approach on traffic accident patients in Korea from 2000 to 2015. Methods We investigated the studies related mind-body approach on traffic accident patients via searching five Korean web databases. Consequently, twenty seven research papers were founded. We classified these papers according to their published year, the ti-tles of journal, the type of study, the number of cases, the sites of injury, the types of treatments, the assessment scales of study, and ethics approvals. Results Twenty seven papers have been published since 2000. the studies related mind-body approach on traffic accident patients were mainly published Journal of Oriental Rehabilitation Medicine, The Acupuncture, and The Korean Society of Oriental Neuropsychiatry. Twenty six papers were clinical research include twenty two case series, two non randomized controlled trials, two randomized controlled trials and one literature review. Visual analog scale and Minnesota multi-phasic personality inventory were used as primary assessments. Only four clinical stud-ies were mentioned about approval of institutional review board. Conclusions In reviewing published papers, damage to the body, as well as emotional and phychological factors are thought to affect the condition or prognosis of traffic accidents patients. Through controlled studies, herbal-medication, acupuncture(Damjeonggyeok), cuppingtherapy showed good effect on decreasing of pain scale and improving of psychological symptoms after traffic accident.

증 례 : 한방병원에 교통사고로 입원한 환자의 입원기간에 영향을 미치는 요인분석

전동휘 ( Dong Hwi Jeon ),이은정 ( Eun Jung Lee ),오민석 ( Min Seok Oh ) 대한한의학회 한방재활의학과학회 2016 한방재활의학과학회지 Vol.26 No.2

Objectives This study was designed to find out influential factors associated with Hospitalization of the patients from traffic accident by Groups. Methods Based on the medical charts, we analyzed statistical study of 486 patients putting them into two groups to identify the factors associated with the duration of hospitalization involving age, sex, elapse day (Interval between time of injury and visit to hospital), and the types of accident. Patients in group A were diagnosed with a mere ``sprain``, and patients in Group B had other symptoms accompanied by ``sprain``. Results 1. In group A, cervical sprain was the most and male patients with the symptom outnumbered female patients. In group B, headache was most where female patients had the symptom 1.7 times more than male patients. 2. Female patients in group B were found to stay for a longer period of time in the hospital than the male counterparts (p<0.05). 3. Both group A and B have positive correlation between length of hospital stay and age though group B exhibited stronger correlation. 4. Patients who had accident while riding bus in group A and those who were pedestrians in group B were found to stay in the hospital for a significantly longer period of time than those who had any other types of accident (p<0.05). Conclusions We noticed that hospital stay lengthened when the patients were older and when they had accidents while riding bus in Group A whereas in Group B, patients stayed longer when they were females and older as well as when they were pedestrians in accidents. (J Korean Med Rehab 2016;26(2):133-144)

편타성 손상에 의한 경항통 및 두통 환자의 추나요법 병행 한방복합치료의 효과: 후향적 관찰연구 - 앙와위 경추 JS 신연 교정기법을 중심으로

김남훈 ( Namhoon Kim ),전동휘 ( Dong-hwi Jeon ),이정민 ( Jung Min Lee ),오민석 ( Minseok Oh ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.2

Objectives To observe the pain reduction effect of Korean medical treatment combined with supine JS cervical therapy on neck pain and headache caused by whiplash injury. Methods The medical records of 30 patients suffering from neck pain and headache caused by traffic accidents from August 1, 2020 to October 30, 2020 were studied. 15 patients receiving supine JS cervical therapy combined with Korean medical treatment were assigned to group A and another 15 patients receiving Korean medical treatment but without Chuna therapy were assigned to group B. The following patient data were analyzed retrospectively - age, sex, and number of admission days, neck pain and headache visual analogue scale (VAS), and neck disability index (NDI). Statistical analysis was conducted using IBM SPSS 25.0. for Windows. A p-value≤ 0.05 was considered to be statistically significant. Results Both neck pain and headache VAS score in group A and B showed a statistically significant decrease. The changes in neck pain and headache VAS score in group A was statistically significant higher compared to those of group B. NDI in group A showed a statistically significant decrease, but NDI in group B did not decreased statistically significant. Conclusions Korean medicine treatment effectively reduces neck pain and headache. Especially, the pain reduction effect is better in patients receiving Korean medicine treatment combined with supine JS cervical therapy than in those receiving Korean medicine treatment without supine JS cervical therapy. (J Korean Med Rehabil 2021;31(2):57-67)

육미지황탕(六味地黃湯)이 대퇴골절 동물모델의 골절 유합인자 및 형태학적 변화에 미치는 영향

김현석 ( Hyun-seok Kim ),전동휘 ( Dong Hwi Jeon ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.4

Objectives The purpose of this study is to evaluate the healing effect of Yukmijihwangtang (YM) on femur fractured mice. Methods Mice were randomly divided into 6 groups: normal, control, positive control, YM with low, medium, high dosage each. All groups were prepared with femur fracture and treated diffrently. In order to measure bone regeneration effects, we analysed the levels of cyclooxygenase-2 (COX2), bone morphogenetic protein-2 (BMP2), collagen type Ⅱ alpha 1 chain (Col2a1), Sox9, runt-related transcription factor 2 (Runx2), and osterix genes expressed in bone. For morphological analysis, muscles were removed and femur was observed with naked eye. Results COX2 gene expression in bone marrow significantly decreased. BMP2 gene expression significantly increased. Col2a1 gene expression significantly increased. Sox9 gene expression increased as well. Runx2 gene expression in bone marrow increased, but there was no statistical significance. Osterix gene expression significantly increased. Union of the fracture site progressed more in YM group compared to the control group. The fracture union score was significantly decreased in YM group compared to the control group. Conclusions YM showed anti-inflammatory effect, promoted bone regeneration by stimulating the bone regeneration factor. In conclusion, YM can help fracture healing and it well be applied clinically to patients with fracture. (J Korean Med Rehabil 2020;30(4):17-30)

견관절 전방 통증 환자에서 초음파 유도하 견쇄관절 소염약침요법 병행 치료의 효과: 후향적 연구

김상우 ( Sang Woo Kim ),전동휘 ( Dong-hwi Jeon ),김병준 ( Byung-jun Kim ),박정욱 ( Jeong-wook Park ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.3

Objectives The purpose of this study was to observe effectiveness of ultrasound-guided Soyeom pharmacopuncture therapy at acromioclavicular joint of shoulder in patients with anterior shoulder pain. Methods We analyzed medical records of 9 patients hospitalized with anterior shoulder pain who had admitted to Department of Korean Rehabilitation Medicine, College of Korean Medicine, Daejeon University from March 1, 2021 to June 13, 2021. 9 patients were treated the treatment of Soyeom pharmacopuncture therapy on acromioclavicular joint under ultrasonic guidance with Korean medicine treatment (such as herbal medicine, acupuncture, moxabustion, etc). The study was conducted as a retrospective observation study which analyze the patient’s medical records. We used numeric rating scale (NRS) to evaluate pain reduction and the shoulder range of motion (ROM) to evaluate function improvement twice (before pharmacopuncture treatment and 5 days later treatment). Statistical analysis was performed using the IBM SPSS Statistics version 25 program (IBM Co., Armonk, NY, USA). Results The average of numeric rating scale reduced statistically significantly from 5.56±1.13 to 3.11±1.36 (p=0.004). The average of shoulder flexion ROM increased statistically significantly from 166.67±8.17° to 175.00±8.37° (p<0.05). And the average of shoulder abduction ROM increased statistically significantly from 158.57±20.35° to 172.86±12.53° (p<0.05). Both NRS and shouler ROM showed statistically significantly improve after treatment. Conclusions This study shows ultrasound-guided Soyeom pharmacopuncture therapy at acromioclavicular joint of shoulder has a meaningful clinical effect on the improving shoulder pain and ROM especially on flexion and abduction. (J Korean Med Rehabil 2021;31(3):95-104)

교통사고로 유발된 급성 요통 환자의 후관절 소염약침 치료에 대한 초음파 유도하군과 비유도군의 효과 비교: 후향적 연구

박정욱 ( Jeong-wook Park ),김상우 ( Sang Woo Kim ),전동휘 ( Dong-hwi Jeon ),김병준 ( Byung-jun Kim ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.3

Objectives This study aims to compare the effect of an ultrasound on a guided group and an unguided group on Soyeom pharmacopuncture therapy on the facet joint in patients with acute low back pain caused by traffic accidents. Methods 21 patients with acute low back pain caused by traffic accidents from March 1, 2021 to May 31, 2021 were included in this study. The study was conducted as a retrospective study which analyzes the patient’s medical records. 11 patients (Group A) received ultrasound guided Soyeom pharmacopuncture therapy and 10 patients (Group B) received unguided Soyeom pharmacopuncture therapy on the facet joint. Visual analogue scale (VAS) and Oswestry disability index (ODI) was used to evaluate improvements in functions and pain, and five point Likert scale to evaluate patient’s satisfaction. Results Both groups showed a statistically significant decrease in the VAS and ODI on the 5th day of hospitalization. However, there was no statistically significant difference between the groups. Difference in the Likert scale between the groups was not statistically significant either. Conclusions We found that ultrasound guided Soyeom pharmacopuncture therapy on the facet joint showed similar efficacy compared with unguided Soyeom pharmacopuncture therapy at facet joint on acute low back pain patients caused by traffic accidents. (J Korean Med Rehabil 2021;31(3):85-93)

임상에서 흔히 접하는 통증에 대한 소염약침요법의 체계적 문헌고찰

김명규 ( Myeong-kyu Kim ),서하라 ( Ha-ra Seo ),하현주 ( Hyun-ju Ha ),오태영 ( Tae-yeong O ),전동휘 ( Dong-hwi Jeon ),이옥진 ( Yu-chen Li ),이재은 ( Jae-eun Lee ),이은정 ( Eun-jung Lee ),오민석 ( Min-seok Oh ) 대한한의학회 한방재활의학과학회 2017 한방재활의학과학회지 Vol.27 No.3

Objectives To evaluate the evidence supporting the effectiveness of Soyeom pharmacopuncture therapy for Pain. Methods We conducted search across 6 electronic databases (Pubmed, CAJ, Oasis, RISS, DBPIA and KoreanTK) and 2 journals to find clinical trials that used Soyeom pharmacopuncture therapy as treatment for pain. The methodological quality of Randomized controlled clinical trials (RCTs) was assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clinical trials) were assessed using the Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Among 75 articles that were searched, 5 RCTs and 2 NRCTs were finally selected. Among 7 selected studies, all studies showed that Soyeom pharmacopuncture therapy has significant effect on Pain. Conclusions Our systematic review found encouraging but limited evidence of Soyeom pharmacopuncture therapy for Pain. We recommend clinical trials which compare the effectiveness of Soyeom pharmacopuncture therapy with other pharmacopuncture therapies to clarify the effectiveness of Soyeom pharmacopuncture therapy from other pharmacopuncture therapies. (J Korean Med Rehabil 2017;27(3):95-105)