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생약복합제제의 약효연구 (제13보) : 대자호탕이 혈관, 간독성, 이당 및 항당뇨효과에 대하여
홍남두(N. D. Hong),장인규(I. K. Chang),김남재(N. J. Kim),손정곤(J. G. Shon) 한국생약학회 1983 생약학회지 Vol.14 No.1
These studies were conducted in an attempt to investigate effects of Daeshiho-Tang on the blood vessels, activities of liver enzyme and excretory action of bile juice in serum of CCl₄-intoxicated rabbits, glucose and total cholesterol levels in serum of alloxan-induced diabetic rabbits. The result of these studies were summerized as follows; 1. Hypotensive and vaso-dilatating actions due to vascular smooth muscle relaxation were noted in frogs, rabbits and dogs. 2. GOT, GPT and total cholesterol in serum of CCl₄-intoxicated rabbits showed significant depressive effects. 3. Significantly increased biliary secretory effect was noted in CCl₄-intoxicated rabbits. 4. Glucose and total cholesterol levels showed markedly decraese in alloxan-induced diabetic rabbits. Considering the experimental studies results, it is suggested that Daeshiho-Tang has therapeutic efficacy to treat febrile diseses and metabolic diseases.