국민청원 사이트 웹 크롤링 및 형태소 분석을 통한 시각화

임세진(Sejin Lim),좌민경(Minkyoung Jwa),최태혁(TaeHyeok Choi),주종화(Jong Wha J. Joo) 한국정보기술학회 2020 Proceedings of KIIT Conference Vol.2020 No.10

최근 코로나, N번방 등과 같은 사회적 문제가 대두되면서 국민청원 사이트에 관심을 가지고 문제에 관한 방안, 의견 등을 제시하는 국민들이 많아지고 있다. 하지만 현재의 국민청원 홈페이지에서는 카테고리 별로 어떤 내용이 이슈가 되고 있는지, 과거에는 어떤 내용이 주목을 받았었는지 한눈에 파악하기 어렵다. 이에 따라 현재의 국민청원 홈페이지에 올라온 청원들을 크롤링 후 형태소 분석을 통해서 데이터를 수집 및 정제하여 시각화된 웹사이트(http://petition.ga)를 제공함으로써 국민들이 청원에 대해서 파악하기 쉽게 하였다. With the recent emergence of social issues such as COVID-19 and Nth room, more and more people are interested in the national petition site and suggest ways and opinions on the issue. However, it is difficult to grasp at a glance what content has become an issue for each category on the current website of the petition, and what contents have received attention in the past. Accordingly, petitions posted on the current national petition website were collected and cleaned through Web Crawling and Morphological Analysis, visualized on the website, making it easier for the public to understand the topic.

양자컴퓨터 플랫폼 동향

임세진(SeJin Lim),김현지(Hyunji Kim),김덕영(Dukyoung Kim),장경배(Kyungbae Jang),양유진(Yujin Yang),오유진(Yujin Oh),서화정(Hwajeong Seo) 한국정보보호학회 2023 情報保護學會誌 Vol.33 No.2

검정콩 추출물이 납과 카드뮴을 투여한 흰쥐의 혈청 효소 활성도에 미치는 영향

한성희(Sung Hee Han),신미경(Mee Kung Shin),김용욱(Yong Wook Kim),임세진(Sejin-Lim) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.2

검정콩 추출물이 납과 카드뮴을 투여한 흰쥐의 식이섭취량과 체중변화 및 혈청 효소활성도에 미치는 영향을 조사한 결과 식이섭취량은 검정콩 추출물군의 21.52~23.08g이 납과 카드뮴 투여군에서 각각 17.07~18.08 g과 14.19~15.76 g으로 감소되었으며 검정콩 추출물에 중금속 동시 투여군은 19.35~20.82 g으로 중금속 단독 투여군보다는 증가되었다. 최종일 체중 증가량을 보면 검정콩 단독 추출물 투여군은 278.12~291.73 g으로 납과 카드뮴 단독 투여군은 252.98~264.78 g으로 검정콩 단독 추출물군에 비하여 감소되었고 검정콩과 납 및 카드뮴 동시 투여군의 체중 증가량은 290.92~295.78 g으로 중금속 단독 투여군보다는 증가되었다. GPT는 검정콩 추출물군은 65.93~81.28 IU/L으로 농도가 진할수록 감소되었고 중금속 단독 처리군은 83.96~97.23 IU/L로 비교적 높았으나 검정콩 추출물에 중금속 동시 처리군은 57.98~63.02 IU/L로 중금속 단독 처리군에 비하여 감소되었다. GOT는 검정콩 추출물군이 111.93~126.68이었으나 농도가 진할수록 감소하였고, 중금속 단독 처리군은 130.17~139.62이며 검정콩 추출물에 중금속 단독 처리군은 101.72~109.14 IU/L로 중금속 단독 처리군에 비하여 감소하였다. LDH는 검정콩 추출물군이 542.83~590.80 IU/L으로 대조군인 596.33 IU/L보다 감소하였다. 중금속 단독 처리군은 616.17~695.33 IU/L, 검정콩 추출물과 중금속 동시 투여군은 364.40~422.80 IU/L으로 중금속 단독 처리군에 비하여 감소하였다. ChEase는 검정콩 추출물군은 77.67~81.40IU/L이며 중금속 단독 처리군은 60.33 ~66.50 IU/L으로 검정콩 추출물과 중금속을 동시에 처리한 군은 72.40~84.20 IU/L으로 검정콩 추출물 단독 투여군이 증가하였다. 이상의 결과로 미루어 볼 때 검정콩 추출물이 흰쥐의 납과 카드뮴 중독으로 인해 증가된 혈청중의 효소 활성을 유의성있게 저하시켜 검정콩 추출물이 납과 카드뮴 중독을 어느 정도 완화시킬수 있어 간의 해독 및 각 조직 세포손상에 대한 억제 효과가 어느 정도 있을 것으로 생각된다. The effects of black soybean extracts on enzymes activies of rat were evaluated in present study. Eighty-four male Sprague-Dawley rats weighing 100±10 g were divided into twelve groups which consisted of black soybean extract, Pb and Cd solution, and black soybean extract plus Pb or Cd soln groups. The weight gain was increased in black soybean extracts and Pb soln solution group but decreased in Cd soln solution group. The results obtained from the experiment were as follows: Glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) activities were not significantly different among experimental groups. The lactate dehydrogenase (LDH) activities of black soybean extract administered groups were decreased than those of Pb and Cd solution group. Black soybean group increased cholinesterase (ChEase) activity as compared to administration of Pb and Cd soln group.

1,2-Disubstituted-3-phenoxybenzenes의 합성 및 항진균활성

임세진 동덕여자대학교 종합약학연구소 2004 동덕약학연구지 Vol.8 No.-

Chitin synthases play a crucial role in the formation of chitin, which serves as mechanical support and protective barrier for cell walls in yeast and fungi and are attractive targets for drugs designed to cure fungal diseases. Recently, a novel chitin synthase inhibitor, obovatol was isolated from the extract of leaves of Magnola obovata. It showed antifungal activities against various pathogenic fungi. To investigate the structural factors responsible for the potent activity of obovatol, its derivatives, 1,2-disubstituted-3-phenoxybenzenes were synthesized. These diaryl ether compounds were synthesized by copper-catalyzed Ullmann reaction using either Cu(OAC)_(2) or (CuOTf)_(2)ㆍbenzene as catalyst. Demethylation of 1-(4-ethylphenoxy)-2,3-dimethoxybenzene (2) was carried out using BBr_(3) to yield 3-(4-ethylphenoxy)benzene-1,2-diol (3). Compounds 1~3 showed weak inhibitory activity (21-25% inhibition at 81.9 ㎍/ml) against chitin synthase 1 from candida albicans, while compound 4 did not inhibit the enzyme. On the antifungal activity assay against pathogenic fungi, the very low activity (MIC>128 ㎍/ml) was observed for compound 1, 2 and 4. Compound 3 afforded MIC value of 64 ㎍/ml against Candida krusei and Candida albicans.

수용성 코직산 유도체의 합성

임세진 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

Water-soluble urea, thiourea and guanidine derivatives of kojic acid were synthesized. The C-5 hydroxyl of kojic acid was benzyl protected and C-7 hydroxyl was aminated to yield 2-aminomethyl-5-benzyloxy-4-pyrone (2). It was then treated with isocyanate and isothiourea to introduce urea and thiourea moieties, respectively. In case where the isocyanate was unavailable, the urea group was formed by treating compound 2 with 1,1`-carbonyldiimidazole, followed by quenching with the amine. The guanidine group was formed by treating with N,N`-bis(Boc)-N-ethyl-S-ethylisothiourea. Finally, the benzyl protecting group was removed by catalytic hydrogenation to give the products (4, 6, 8, 10).

Spiro hydantoin의 효율적 합성에 관한 연구

임세진,양정완 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

Spiro hydantoins (la-1f) were synthesized by reaction of the corresponding ketones with KCN, (NH4)2CO3 using steel autoclave Wheares ketones including β-tetralone, α-tetralone, 4-phenyl cyclohexanone, 1-benzyl-4-piperidone and tetrahydropyran-4-one were commercially available, 1-phenyl-4-piperidone (4) was synthesized by Michael addition of aniline to ethyl acrylate followed by Dieckmann cyclization, hydrolysis and decarboxylation.

고체상 합성법을 이용한 2,5-diketopiperazines의 합성

신여울,임세진 동덕여자대학교 종합약학연구소 2003 동덕약학연구지 Vol.7 No.-

2,5-Diketopiperazines are important peptidomimetic scaffolds since they are resistant to proteolysis. We have synthesized two simple 2,5-diketopiperazines, (S)-3-Methylpiperazine-2,5-dione(1) and piperazine-2,5-dine (2) using solid-phase synthetic methodology. (S)-3-Methylpiperazine-2,5-dione (1) was obtained by on-resin cyclization of Ala-Gly-resin, whereas piperazine-2,5-dione (2) was made by cleavage of Gly-Gly from the resin, followed by intermolecular cyclization.

고리형 α, α-이치환-α -아미노산을 도입한 펩타이드의 합성과 2차 구조 분석

이경,임세진 동덕여자대학교 종합약학연구소 2005 동덕약학연구지 Vol.9 No.-

α-Helix is a typical secondary structure found in many bioactive proteins, peptides, and fibrous polymers. α,α-Disubstituted amino acid, a special amino acid having two alkyl groups at α-carbon, has a restricted structure. Therefore, once incorporated into a peptide it can modify the degree of freedom and promote the formation of α-helix, also it can stabilize α-helical structure. Previously 1-phenyl-piperidine-4-carboxylic acid(Ppi), a cyclic six-membered α,α-disubstituted α-amino acids had been synthesized in our laboratory. The object of this research was to investigate the tendency of Ppi to promote the formation of peptide secondary structure. We selected two pentapeptides, Boc-Val-ΔPhe-Ala-Leu-Gly-OMe and Boc-Leu-Dbg-Val-Ala-Leu_OMe, which were reported to form α-helices as the control and replaced special amino acids (ΔPhe and Dbg) with Ppi. We synthesized two pentapeptides: Boc-Val-Ppi-Ala-l,eu-Gly-OMe [4] and Boc-Leu-Ppi-Val-Ala-Leu-OMe [8] by using solution-Phase peptide synthesis strategy. Their secondary structures were measured by CD spectroscopy analysis. The control peptide Boc-Val-ΔPhe-Ala-Leu-Gly-OMe made a (-) band near 202 nm and 227~228nm, indicating the formation of α-helical structure. Boc-Val-Ppi-Ala-l,eu-Gly-OMe [4] made a (-) band near 205 nm and Boc-Leu-Ppi-Val-Ala-Leu-OMe [8] made a (-) band near 200~205nm. This means these peptides form a random coil structure. In conclusion, Ppi in two pentapeptides (4,8) did not promote the formation of peptide secondary structure.

4-(9H-Fluoren-9-ylmethozzycarbonylamino)-tetrahydropyran-4-carboxyllc acid의 효율적 합성

양정완,임세진 동덕여자대학교 종합약학연구소 2003 동덕약학연구지 Vol.7 No.-

α, α-Disubstituted amino acids have two alkyl substituents at the α-position of α-amino acids and are conformational restricted. We synthesized 4-amino-tetrahydropyran-4-carboxylic acid as an unusual cyclic α, α-disubstituted amino acid mimicking the natural threonine residue. We have chosen the efficient synthetic route via hydantoin formation from tetrahydropryan-4-one by a Bucherer-Bergs reaction and mild hydrolysis of hydantoin.