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Ethionine 장기투여로 인한 간세포의 lysosome 변화에 대하여
이동구,이학상 최신의학사 1974 最新醫學 Vol.17 No.6
Since de Duve have isolated the lysosome from rat liver cell by the cell fractionation method (1955), many authors have studied the lysosome in the normal or pathological conditions. There are many reports about. the lysosome, especially changes of number and features of it, when the cytotoxic agents are injected. But, in present, many problems are not resolved about the relationship between function and morphology of the lysosome. Author observed lysosomal changes in liver parenchymal cells of the rat after in gestion of 0.25%DL-Ethionine added to basal diet for 6 or 9 months, in order to study the details. The results were: 1. Degenerative or necrotic changes in liver cells were rnoted after long-term ingestion of the DLEthionine. 2. The lysosome was markedly increased with cellular destruction and it could be subdivided to four groups, such as storage granule, digestive vacuole, autophagyic vacuole and residual body, according to the morphological ground. 3. It was believed that the lysosome increased in the degenerative or necrotic process of the cells. 4. The appearance of abnormal structures, focal cytoplasmic degradation. are considered to be related to the phenomena named autophagy or autophagocytosis.
조정실,이용배,이학상,최인준 최신의학사 1974 最新醫學 Vol.17 No.11
Pulmonary sclerosing hemangioma is rare and found mainly in middle aged female. Its etiology is not ceertain though histiocytoma, postinflammatory pseudotumor and true hemangioma are said. A case of pulmonary sclerosing hemangioma in 42 year-old female in Yonsei University, College of Medicine, Department of Pathology, is reported and brief review of literature is made.