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전신성홍반성낭창과 특발성혈소판감소성자반증 환자 혈청에서 항혈소판항체의 출현빈도 및 항원특이성에 관한 연구
송영욱(Yeong Wook Song),이제환(Je Hwan Lee),이윤재(Yoon Jae Lee),박선양(Seon Yang Park),최강원(Kang Won Choe),박명희(Myung Hee Park) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A There is a special relationship between systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP), both of which are autoimmune diseases. Some patients with thromhocytopenic purpura, labeled as idiopathic at the onset, later develop a classical course of SLE, suggesting that ITP may be an early manifestation of SLE. Furthermore, a thrombocytopenic purpura, indistinguishable from ITP, is a common feature of SLE. Recent studies by several laboratories show that some patients with ITP produce autoantibodies against the glycoprotein IIb/IIIa complex and glycoprotein lb. Since in most cases of SLE an increase of platelet-associated IgG has been observed, it was suggested that the destruction of platelets might be dependent on the coating of the platelets with specific antibodies or on the binding of the immune complexes. A better knowledge of the antigen recognized by the antibodies present in the patients with SLE might help to clarify the cause of the thrombocytopenia. In this study, serum antiplatelet antibody was detected using platelet suspension immunofluorescence test in SLE and ITP patients. The positive rate of serum antiplatelet antibody was 85% (17/20) in SLE, 66.7% (10/15) in ITP, 60% (3/5) in platelet alloimmunization, and 0% (0/13) in the normal group. Sera from patients of SLE and ITP were incubated with platelet fractions immobilized on nitrocellulose paper (Western blotting) to detect platelet antigen specificity using a 125I-goat anti-human IgG. Normal sera reacted with platelet fractions in the range of 190~200 KD, 142~152 KD, and 87~90 KD, Howerver, 11 of the 20 SLE sera (55%) and seven of the 15 ITP sera (46.7%), bound to one or more fractions with large variations in the number and molecular weights in the platelet fractions, did not react with normal sera. Binding was directed to the platelet fractions in the range of 162 KD, 117~123 KD, 60~69 KD, 53~55 KD, 40~45 KD, and 37~39 KD in the SLE group, along with 117~123 KD, 106 KD, and 60~69 KD in the ITP group. The antigenic determinants were located in the cytoplasmic fraction of the platelets. This observation surggests the presence of multiple antigenic binding site for platelet-specific immunoglobulin, as well as differences, of antigen specificity in SLE and ITP sera. This variation may reflect heterogeneous antibodies binding to diverse antigens, or homogeneous antibodies bound to a limited number of antigenic determinants shared by the discrete platelet molecules.
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대한외상학회지에 게재된 문헌들의 추세: 계량서지학과 인용을 이용한 분석
예진허치슨 ( Yejin L Hutchison ),차현민 ( Hyun Min Cha ),오재훈 ( Jae Hoon Oh ),강형구 ( Hyung Goo Kang ),임태호 ( Tae Ho Lim ),이윤재 ( Yoon Je Lee ),강보승 ( Bo Seung Kang ),김창선 ( Chang Sun Kim ),최혁중 ( Hyuk Joong Choi ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.3
Purpose: We performed a quantitative and qualitative analysis in the Journal of the Korean Society of Traumatology (JKST) by Bibliometrics to know the trends of articles. Methods: We reviewed articles in the JKST retrospectively through 1988 to 2014. Articles were classified into original articles, case reports, review articles, and also it is further classified as topics and the information related to the Department of Medicine of corresponding author. Original article was classified prospective and retrospective studies. Results: 753 studies and average of 27.9 studies per year were posted on JKST. 576 original articles (76.5%) were posted. Retrospective studies around 449 studies (78%) were posted and there were about 35 descript studies and 541 analytic studies. The most common themes were related to abdominal trauma, 144 pieces, 95 pieces following damage to the chest and the 84 pieces of special order of trauma. Emergency department had the highest case whereas general surgery came to the second place. Conclusion: Recently, there has been reduced proportion of original article in JKST. It was not possible to evaluate the Korea Citation index journals due to the fact that it does not correspond to listed register Journal of National Foundation of Korea. There will be the need for the effort to improve the maintenance of the posted article number, as well as the qualitative development of the posted articles. [ J Trauma Inj 2015; 28: 182-189 ]
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