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금은화(金銀花)와 황금(黃芩)이 배오(配伍)된 처방제(處方劑)의 항염증(抗炎症) 효과(效果) 연구(硏究)
이용숙,장선일,Lee, Yong-Suk,Jang, Seon-Il 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1
Inflammatory reaction is characterized by over-production of inflammatory mediators due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1beta (IL-$1{\beta}$), IL-6, tumour necrosis factor alpha (TNF-$\alpha$), prostaglantin $E_2$ ($PGE_2$), and nitric oxide (NO) in U937 cells. We investigate the anti-inflammatory effects of water extracts from Lonicerae Flos and Scutellariae Radix in lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-$1{\beta}$, TNF-$\alpha$, and $PGE_2$) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. Their combination extract also inhibited NF-${\kappa}B$-DNA complex of NF-${\kappa}B$ binding activity and translocation of NF-${\kappa}B$ from cytosol to nucleus. These results suggest that the combination of water-extractable components of Lonicerae Flos and Scutellariae Radix may be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
이용숙,정명,임규상,윤용갑,Lee, Yong-Suk,Jung, Myung,Lim, Kyu-Sang,Yun, Yong-Gab 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.3
Objective : This study investigated the inflammatory reaction is characterized by over production of inflammatory mediators due to an up-regulation of inflammatory pathways.Methods : We investigated the anti-inflammatory effects of water extracts fromLonicera japonicaandScutellaria baicalensisin lipopolysaccharide (LPS)-stimulated U937 cells. Each extract suppressed the production of inflammatory mediators (NO, IL-1${\beta}$, TNF-${\beta}$, and PGE<sub>2</sub>) and the expression of inducible NO synthase and cyclooxygenase-2 in LPS- stimulated U937 cells in a dose-dependent manner.Results : These suggest that the suppression effects were synergistically increased by their combination. Their combination extract also inhibited NF-${\kappa}B$-DNA complex of NF-${\kappa}B$ binding activity and translocation of NF-${\kappa}B$ from cytosol to nucleus.Conclusions : Our study suggest that the combination of water-extractable components ofL. japonicaandS. baicalensismay be useful for therapeutic drugs against inflammatory immune diseases, probably by suppressing the production of inflammatory mediators.
신병석,노성,정회상,정민석,이용숙,Shin Byeong-Seok,Roh Sung,Jung Hoe-Sang,Chung Min Suk,Lee Yong Sook 대한의용생체공학회 2004 의공학회지 Vol.25 No.6
In order to create three-dimensional model for human body, a method that reconstructs geometric models from contour lines on cross-section images is commonly used. We can get a set of contour lines by acquiring CT or MR images and segmenting anatomical structures. Previously proposed method divides entire contour line into simply matched regions and clefts. Since long processing time is required for reconstructing cleft regions, its performance might be degraded when manipulating complex data such as cross-sections for human body. In this paper, we propose a fast reconstruction method. It generates a triangle strip with single tiling operation for simple region that does not contain branch structures. If there exist branches in contour lines, it partitions the contour line into several sub-contours by considering the number of vertices and their spatial distribution. We implemented an automatic surface reconstruction system by using our method which reconstructs three-dimensional models for anatomical structures. 의학 영상 분야에서 인체에 대한 3차원 모델을 생성하는 데는 평행한 2차원 영상위에 있는 외곽선들로부터 원래 물체의 형상을 복원하는 방법이 일반적으로 사용된다. CT나 MR영상을 획득한 후 해부구조물에 대해서 구역화를 하면 외곽선 집합을 얻을 수 있다. 기존의 표면 재구성 알고리즘은 외곽선을 단순 정합이 가능한 부분과 클레프트(cleft)를 나누어 처리하는데, 클레프트를 처리하는 시간이 오래 걸리기 때문에 모델이 복잡할 경우 수행속도가 저하되는 단점이 있다. 본 논문에서는 분기(branch)가 없는 단순영역을 형태에 관계없이 한번에 타일화하고, 분기가 있는 경우에는 한 외곽선의 정점들을 대응하는 외곽선들의 정점개수와 분포를 고려하여 분할함으로써 간단하고 신속하게 타일화하는 방법을 제안한다. 이 기법을 이용하여 해부구조물의 3차원 모델을 생성하는 표면 재구성 시스템을 구현하였다.