http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 이새배 ( Yang Mo Goo (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
구양모,최석례,김공환,임번삼,이새배,Goo, Yang-Mo,Choi, Seok-Rye,Kim, Kong-Hwan,Lim, Bun-Sam,Lee, Sae-Bae 생화학분자생물학회 1989 한국생화학회지 Vol.22 No.4
Streptomycin을 생성하는 7종의 S. griseus와 1종의 S. galbus의 세포 추출물은 streptomycin을 phosphorylation하여 비활성화 하였다. Phosphorylation에 의한 streptomycin의 비활성화는 모든 streptomycin 생성균주에 공통적으로 존재하는 것으로 생각된다. Neomycin과 paromomycin을 생성하는 S. fradiaea와 S. rimosus forma paromomycinus의 세포추출물은 phosphorylation과 acetylation에 의하여 neomycin을 비활성화하였다. Kanamycin을 생성하는 S. kanamyceticus IFO 13414의 세포추출물도 neomycin을 phosphoryltion 또는 acetylabon시켜 비활성화하나 이 추출물에는 kanamycin에 대한 phosphorylation 효소는 존재하나 acetylation 효소는 존재하지 않은 것으로 확인되었다. 다른 kanamycin 생성균주인 S. kaηamyceticus NRRL 2535는 neomycin과 kanamycin에 강한 내성을 보였으나 이들 항생물질은 acetylation 시키거나 phosphorylation 시키는 효소는 확인되지 않았다. Gentamicin 또는 slsomicin을 생성하는 Micromonospora spp. 들은 gentamicin, kanamycin 그리고 tobramycin에 강한 내성을 보였으나 어떤 종류의 aminoglycoside 항생물질도 phosphorylaton 시키거나 acetylation 시키는 효소는 확인되지 않았다. Aminoglycoside 항생물질을 생성하는 Streptomycetes 들은 자신들이 생성하는 항생물질 뿐만 아니라 유사한 구조를 갖는 다른 항생물질에 대하여서도 특이한 내성메카니즘을 소유하고 있는 것으로 확인되었다. The cell free extracts of streptomycin producers, 7 strains of S. griseus and 1 strain of S. galbus inactivate streptomycin by phosphorylation, and the resistant mechanism against streptomycin by phosphorylation seems to be popular in streptomycin producing organisms. The cell free extracts of neomycin and paromomycin producers, S. fradiae and S. rimosus forma paromomycinus inactivate neomycin not only by phosphorylation, but also by acetylation. The cell free extract of a kanamycin producer. S. kanamyceticus (IFO 13414) inactivates neomycin by phosphorylation and/or by acetylation. However it does not inactivate kanamycin by phosphorylation but does by acetylation. The cell free extracts of the other kanamycin producer. S. kanamyceticus (NRRL 2535) does not show any inactivation of neomycin as well as kanamycin by phosphorylation or by acetylation, although it shows strong resisance against the antibiotics. The cell free extracts of Micromonospora spp.. producers of gentamicin or sisomicin which show resistance against gentamicin, kanamycin and tobramycin do not possess any phosphorylating or acetylating enzymes for the aminoglycoside antibiotics employed in this study. The Streptomycetes producing aminoglycoside antibiotics seem to have characteristic resistance mechanisms against the antibiotics produced by themselves and against other similar antibiotics.
-
Aminoglycoside 항생물질을 생성하는 Streptomycetes 와 Micromonospora spp 들의 Aminoglycoside 항생물질 변형효소에 관한 연구
구양모,최석례,김공환,임번삼,이새배 ( Yang Mo Goo,Seok Rye Choi,Kong Hwan Kim,Bun Sam Lim,Sae Bae Lee ) 생화학분자생물학회 1989 BMB Reports Vol.22 No.4
The cell free extracts of streptomycin producers, 7 strains of S. griseus and 1 strain of S. galbus inactivate streptomycin by phosphorylation, and the resistant mechanism against streptomycin by phosphorylation seems to be popular in streptomycin producing organisms. The cell free extracts of neomycin and paromomycin producers, S. fradiae and S. rimosus forma paromomycinus inactivate neomycin not only by phosphorylation, but also by acetylation. The cell free extract of a kanamycin producer. S. kanamyceticus (IFO 13414) inactivates neomycin by phosphorylation and/or by acetylation. However it does not inactivate kanamycin by phosphorylation but does by acetylation. The cell free extracts of the other kanamycin producer, S. kanamyceticus (NRRL 2535) does not show any inactivation of neomycin as well as kanamycin by phosphorylation or by acetylation, although it shows strong resisance against the antibiotics. The cell free extracts of Micromonospora spp.. producers of gentamicin or sisomicin which show resistance against gentamicin, kanamycin and tobramycin do not possess any phosphorylating or acetylating enzymes for the aminoglycoside antibiotics employed in this study. The Streptomycetes producing aminoglycoside antibiotics seem to have characteristic resistance mechanisms against the antibiotics produced by themselves and against other similar antibiotics.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
