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소아천식 환자에서 충격진동법과 폐활량기로 측정한 소기도 장애와 호기산화질소와의 관계
서보선 ( Bo Seon Seo ),이정민 ( Jeong Min Lee ),조은혜 ( Eunhae Cho ),백지현 ( Ji Hyeon Baek ),이경석 ( Geong Suk Lee ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),정영호 ( Yong Ho Jung ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
Purpose: Fractional exhaled nitric oxide (FeNO) is a maker of airway inflammation, and impedance of low frequency in the impulse oscillometry system (IOS) reflects small-airway obstruction. We investigated the association of the FeNO level with IOS parameters and spirometry results in asthma patients. Methods: Fifty-eight children with asthma (60.3%, male), mean age 8.3 years (range, 4.5.16.0 years), were enrolled in the study. Reactance and resistance at 5 Hz with IOS, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and forced expiratory flow 25%.75% of the vital capacity (FEF25%-75%) with spirometry and FeNO were measured in all patients. The Z-score of spirometry and IOS parameters and the mean level of FeNO were used for correlation and regression analysis. Results: FeNO was not significantly associated with height, age, or other demographic parameters. There was a statistically significant correlation between spirometry results and IOS measurements. The FeNO level was not significantly correlated with IOS variables. After adjusting for height, sex, atopic status, and the use of inhaled corticosteroid, the FeNO level showed significant correlations with Z-score of FEV1/FVC (P=0.037, adjusted R2=0.234). Conclusion: FeNO was significantly correlated with Z-scores of FEV1/FVC, but not with IOS variables. Therefore, FeNO may be used to detect whole airway obstruction, but not small-airway obstruction. (Allergy Asthma Respir Dis 2015;3:267-271)