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백서를 이용한 포르말린 통증 모형하에서 뇌실 내 Gabapentin의 효과
윤명하(Myung Ha Yoon),곽상현(Sang Hyun Kwak),정성수(Sung Su Chung),유경연(Kyung Yeon Yoo),정창연(Chang Young Jeong),임응모(Woong Mo Im) 대한통증학회 2000 The Korean Journal of Pain Vol.13 No.2
N/A Background: Systemic or intrathecal administration of gabapentin has been shown to reverse various pain states. However, until now, the effect of intracerebroventricular (ICV) gabapentin to noxious stimuli has not been reported. The authors aim of this study was to determine the effect of ICV gabapentin on the inflammatory nociceptive model, formalin test, in rats. Methods: ICV catheters were implanted under halothane anesthesia. For the nociceptive test, 50μl of 5% formalin was subcutaneously injected into the hindpaw. The effect of ICV gabapentin, administered 10 min before formalin injection, were examined on flinching, mean arterial pressure and heart rate evoked by a injection of formalin. Results: Injection of formalin into the paw resulted in a biphasic flinching and cardiovascular response. ICV gabapentin produced a dose-dependent suppression of the flinching and mean arterial pressure response during phase 1. In contrast, in phase 2, ICV gabapentin did not attenuate the pain behavior. ICV gabapentin did not affect on the baseline mean arterial pressure and heart rate. Conclusions: ICV gbapentin was effective for the acute noxious stimulus but it had no effect on the facilitated states induced by tissue injury.
윤명하(Myung-Ha Yoon),최남열(Nam-Yerl Choi),이치환(Chi-Hwan Lee) 전력전자학회 2002 전력전자학술대회 논문집 Vol.- No.-
본 연구는 관성의 변화, 비선형 마찰 등에 견실한 피드포워드 적응 위치제어기를 제안한다. 제안된 적응 위치제어기의 특징은 제어기 적응파라미터가 위치 오차에 기준 모델의 속도 정보를 받아들여 셀프 튜닝된다. 이것은 과도응답 특성을 향상시키고, 정상상태의 수렴 시간을 줄여 시스템의 성능을 개선시킨다. 시뮬레이션을 통하여 제안된 피드포워드 적용 위치제어기의 동작과 설계 방법의 타당성을 보였다.
쥐의 포르말린 시험에서 척수강 Sildenafil의 항통각효과에 대한 GABA<sub>B</sub> 수용체 조절성
김웅모,윤명하,이형곤,한용구,김여옥,황란희,최금화,Kim, Woong Mo,Yoon, Myung Ha,Lee, Hyung Gon,Han, Yong Gu,Kim, Yeo Ok,Huang, Lan Ji,Cui, Jin Hua 대한통증학회 2007 The Korean Journal of Pain Vol.20 No.2
Background: A phosphodiesterase 5 inhibitor, sildenafil, has been effective against nociception. Several lines of evidence have demonstrated the role of the GABAergic pathway in the modulation of nociception. The impact of the GABA receptors on sildenafil was studied using the formalin test at the spinal level. Methods: Male SD rats were prepared for intrathecal catheterization. The formalin test was induced by subcutaneous injection of formalin solution. The change in the activity of sildenafil was examined after pre-treatment with GABA receptor antagonists ($GABA_A$ receptor antagonist, bicuculline; $GABA_B$ receptor antagonist, saclofen). Results: Intrathecal sildenafil dose-dependently attenuated the flinching observed during phase 1 and 2 in the formalin test. The antinociceptive effect of sildenafil was reversed by the $GABA_B$ receptor antagonist (saclofen) but not by the $GABA_A$ receptor antagonist (bicuculline) in both phases. Conclusions: Intrathecal sildenafil suppressed acute pain and the facilitated pain state. The antinociception of sildenafil is mediated via the $GABA_B$ receptor, but not the $GABA_A$ receptor, at the spinal level.
Propofol과 Remifentanil을 이용한 목표농도조절 주입 전정맥마취에서 이중관 기관내관 삽관 시 혈역학적 반응을 억제하는 Remifentanil의 효과처 농도
허봉하 ( Bong Ha Heo ),윤명하 ( Myung Ha Yoon ),이형곤 ( Hyung Gon Lee ),김웅모 ( Woong Mo Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.1
Background: This study was undertaken to determine the effect-site concentration of remifentanil for blunting hemodynamic responses to double lumen endobronchial intubation during target controlled infusion (TCI)-total intravenous anesthesia (TIVA) using 4.0 μg/ml of propofol with remifentanil. Methods: Sixty patients (American society of anesthesiologists physical status classification 1 or 2) were randomly allocated according to the target effect-site concentration of remifentanil (R3.0: remifentanil 3.0 ng/ml; R3.5: remifentanil 3.5 ng/ml; R4.0: remifentanil 4.0 ng/ml). The effect-site concentration of propofol at loss of consciousness was recorded. Mean arterial pressure (MAP), heart rate (HR) and bispectral index (BIS) were recorded at just before remifentanil administration (baseline), at the time of target effect site concentration of remifentanil and propofol, at just before intubation and 1, 2, 3 min after intubation. Results: MAP was significantly increased compared with baseline at 1, 2 min after intubation in R3.0, but was significantly decreased in R4.0. MAP of R3.5 was not different from the baseline after intubation. HR was significantly decreased compared with baseline at the time of target effect site concentration of propofol and immediate before intubation in R3.5 and R4.0. After intubation, HR was significantly increased compared with baseline at only 1 min after intubation and returned to the baseline in R3.0. However, HR was continuously decreased in R4.0. Conclusions: These findings suggest that effective target effect-site concentration of remifentanil for blunting hemodynamic responses to double lumen endotracheal intubation was 3.5 ng/ml during TCI-TIVA using 4.0 μg/ml of propofol with remifentanil. (Korean J Anesthesiol 2009; 57: 8~12)
임상연구 : 위절제술 후 경막외강 Fentanyl-Neostigmine의 진통효과
김세열 ( Se Yol Kim ),윤명하 ( Myung Ha Yoon ),김석재 ( Seok Jai Kim ),정성태 ( Sung Tae Chung ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.2
Background: This study evaluated the efficacy of an epidural single dose of neostigmine combined with fentanyl to provide postoperative analgesia after radical subtotal gastrectomy. Methods: Fifty two adults patients with ASA physical status 1 and 2 are randomly allocated to receive a single injection of either epidural fentanyl 100μg or combination of fentanyl 100μg with neostigmine 250, 500 and 750μg in a total volume of 10 ml. Pain scores were recorded after 0, 5, 10, 15, 20, 30 mins to determine the onset of analgesia. Patients` vital signs as well as side effects were monitored at regular intervals. Results: Patients` demographic data were not different from each other. Epidural neostigmine 750μg with fentanyl 100μg produced effective analgesia (visual analog scale at 10 min; 35 ± 10.6 mm). The time to first rescue analgesics administration was significantly longer in the neostigmine group (250μg: 84.2 ± 9.4, 500μg: 90.9 ± 7.1, 750μg: 92.5 ± 14.4 min) than the control group (53.0 ± 20.0 min). Conclusions: Combination of fentanyl with neostigmine was proven to be more effective for treating postoperative pain after subtotal gastrectomy than fentanyl alone. Additionally, the most effective dose of epidural neostigmine was 750μg. (Korean J Anesthesiol 2007; 53: 217~21)