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Sodium Levothyroxine의 造血促進 效果에 關한 實驗的硏究
尹基潤,黃基錫 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.1
The hemopoietic effect of sodium levothyroxine in the albino rats was studied with the following results. 1) In rats administered sodium levothyroxine orally at 4 ㎍/㎏ of body weight daily for four week's, a significant rise in reticulocyte was noted whereas no noticeable changes were found in hemoglobin, neutrophil and platelet. Also no appreciable differences were observed in nucleated cell and megakaryocyte counts in marrow, RBC ^59Fe uptake and plasma ^59Fe disappearance half time as compared with those of the control group, 2) In the rats treated with an oral administration of sodium levothyroxine at 40㎍/㎏ of body weight daily for four weeks, significant increases in hemoglobin and reticulocyte were observed whereas both neutrophil and platelet revealed no significant changes, the nucleated cell count and megakaryocyte counts in the marrow as well as the plasma ^59Fe disappearance half time were not significantly altered but only the RBC ^59Fe uptake was increased as compared with those of the control group. 3) In rats given sodium levothyroxine at 400ug/㎏ of body weight daily for four weeks, both hemoglobin and reticulocyte were increased remarkably compared with those of the 40ug-administered group although neutrophil and platelet were not changed. As compared with those of the control group, both increased nucleated cell count, in the marrow RBC ^59Fe uptake, and shortened plasma ^59Fe disappearance half time were noted but only the megakaryocyte count disclosed no variation. 4) Rats given sodium levothyroxine orally at 40㎍/㎏ of body weight daily for four weeks after a total 3.0ml. of blood had been drawn, exhibited earlier recovery of hemoglobin as well as greater increase in reticulocyte as compared with the control group in which only blood had been drawn.