Brassiere내의 크롬 분석

유한동(Han Dong Yoo),이무형(Mu Hyoung Lee),최중명(Joong Myung Choi),허충림(Choong Rim Haw) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.4

Background : Chrome has been known to be a toxic and poten sensitizer and is contained in materials with which we are in frequent contact. But we have few reports detailing chrome contact dermatitis by clothes or the chrome content of materials in out use. Objectivee : Our purpose was to evaluate the chrome content in rassieres. Methode : We analyzed chrome in brassieres by using atomied absorption spectrophotometer, quantitatively and diphenylcarbazide method, qualitatively. Results : The content of chrome in a 24 hour saline extracted g roup, a 48 hour saline extracted group and a pure nitric acid extracted group in the black was more abundant than in the reds or in the whites. But there was no aignificant difference in the different fabrics of the blacks. Conclusion : Although, in reality, it is hard to change chrome to an other substrate as the mordant of dyes, a limitation needed to prevent diseases induced by chrome during the process of dyeing. If someone has a sensitivity to chrome, it is necessary to wash new clothes before waring and to avoid black colored underwear. (Kor J Oermatol 19S4; 32(4)': 620-625)

방사선 조사가 배양된 인체 각질형성세포 및 멜라닌세포에 미치는 영향

유한동(Han Dong Yoo),김낙인(Nack In Kim),박재경(Jai Kyung Park),홍성언(Seong Eon Hong),허충림(Choong Rim Haw) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

Background : Radiation has been used in t,he medical field of dragnosis and treatment. There is widely used ionizing radiat:ion such as naturally occuring r-rays or machine-made X-ray. This radiation is able to induce the structural and functional alterations of the mammalian cells. But we have few detailed reports on the effects of radiation on epidermal cells and their immune functions. Objective : This study was performed to investigate the effect of radiation on cultured human keratinocytes and melanocytes. Materials and Methods : Cultured human keratinocytes and melanocytes were irradiated with 2,6, l0Gy from a Co saurce and stimulated by 100 U/ml of ekratinocyte immediately after irradiation. We investigated cell numbers and morphological changes, DNA synthesis and HLA-DR antigen expression. Results : After exposure to r-ray, the proliferation of keratinocytes and melanocytes decreased in a time and dose dependent fashion to each control group. Tliey showed decreased density, a larger size and a round appearance after radiation exposure and an especially shortened and decreased number of dendrites in the melanocytes. In DNA synthesis counted using [H]-thymidine incorporation, the keratinocvtes decreased values in a dose depen(lent manner at 24 and 72 hours after irradiation but no differense was observed at 168 hours. In melanocytes, there was a greater decrease than that of keratinocytes. The melanin content/cell in all radiation exposed groups increased in a time and dose dependent fashion t,o each contr ol group. HLA-DR antigen expression on keratinocytes after radiat,ion exposure decreased to the control group, but there were no significant differences acccirding to the dose of radiation, And there were no significant diifferences of HLA-DR antigen expression on the melanocytes betweer. controls and the radiation exposed groups. Conclusion : Antiproliferative activity was dependent on the exposure time and dose of r-ray exposure. According to the time after radiation exposure, melanogenic activity was stimulated. The expression of HLA-DR, antigen decreased in keratinocyte after radiation exposure but there was no decrease in melanocytes. (Kor J Dermatol 1994:32(4); 609-619)

배양 정상 인체 멜라닌세포의 증식과 멜라닌화에 8 - Methoxypsoralen이 미치는 영향

이무형(My Hyoung Lee),유한동(Han Dong Yoo),박재경(Jai Kyung Park),허충림(Choong Rim Haw) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Background : Psoralen has been used in the treatment of certain hypojigmentary disorders with UVA or solar irradiation. However trecent report proposed the actions of psiralens are direct and do not require the presence of ultraviolet light. The report also suggested that tze specific receptors other than DNA would be present. Objective : This study was done ta identify the effects of 8-methoryporalen(8-MOP) on the proliferation and melanization of cultured normal human melanocytes without UVA. Methods : Melanocytes were cultured in melanocyte culture medium neluding 16% or 5% FBS. We added 8-MOP by their concentrations from 10 M to 10 M. After 8 hours treatment, we investigated the melanocytes proliferation and Lhe melanin contents. Results : We could not detecet any significant differences of melanoytes proliferation and melanin contents between the control end experimental groups. Conclusion : There were no effect on the proliferation and the milanization of cultured normal human melanocytes with 8-MOP onl. (Kor J Dermatol 1994;32(5),:832-837)

가족성 심장 점액종을 보인 Carney ` s Complex

박지용 ( Ji Yong Park ),유한동 ( Han Dong Yoo ),김낙인 ( Nack In Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

The Carneys complex is a multisystemic tumorous disorder that features myxoma(heart, skin, and breast), spotty skin pigmentation(cutaneous and mucocutaneous), endocrine tumors(adrenal, testicular, and pituitary) and peripheral nerve tumors. The criteria far diagnosis of the complex is the presence of two or more of the above conditions. The condition is transmitted as an autosomal dominant trait. The most serious components of the syndrome are cardiac myxoma and psammomatous melanotic schwannoma. The cutaneous manifestations are a major clue in the disorder. We report a case of Carneys complex in a 19-year-old woman. She had spotty pigmentation on her face, left atrial myxoma, and myxoma on her right nipple. Her mother and sister had left atrial myxoma. (Korean J Dermatol 1998;36(5) : 942-945)

DWT와 GPS/INS융합 알고리즘을 이용한 수면이동체의 위치 인식

최원석(Won-Suck Choi),이장명(Jang-Myung Lee),유한동(Han-Dong Yoo),이인욱(In-Uk Lee) 한국로봇학회(논문지) 2015 로봇학회 논문지 Vol.10 No.1

백반증환자의 광선에 노출된 피부에서 Tenascin의 면역조직화학적 변화

양연모(Yeon Mo Yang),이원규(Won-Kyu Lee),진경실(Kyung-Sil Jin),이영일(Young IL Lee),김대성(Dae Sung Kim),유한동(Han Dong Yoo),안희경(Hee Kyung Ahn) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.1

백반증으로 진단 받은 환자에서 일광 노출 부위인 얼굴과 위팔의 피부 조직의 tenascin의 분포를 면역조직화학적 방법 을 이용하여 분석하였다. 실험군인 백반증 환자의 병변부에서 tenascin의 발현 부위는 대조군과 일치하나, 발현양은 증가되어 있었다. 실험군에서 는 특히, 표피 바닥층과 바닥판을 포함한 진피유두 부위에서 염색 정도가 현저히 증가되었다. Wilcoxon rank sum test를 시행한 결과 P = 0.0108로서 대조군에 비해 실험군이 유의하게 증가함을 알 수 있었다. 광선에 노출된 백반증조직에서 tenascin의 증가는 광손상에 의한 바닥층 각질세포에서의 tenascin 합성의 결과와 관련이 있는 것으로 추정되며, tenascin이 항부착작용을 통해 멜라닌세포의 이주 및 접착의 이상에 영향을 미칠 것으로 생각된다. 유병기간과 tenascin과의 관계 및 멜라닌의 존재와의 관계는 추후 더 연구되어야 할 과제이나, 본 연구에서는, 특히 피부탈색질환의 치료로서 현재도 많이 이용되고 있는 광선치료 (phototherapy)가 백반증의 유발원인과 과정에 따라서는 환자에게 유해할 수도 있음을 고려해야 한다고 생각된다. Tenascin is suggested the one of cause of vitiligo by interfering melanocyte adhesion and migration. The distribution and expression levels of tenascin were examined by semiquantitative immunohistochemistry on skin biopsies from vitiligo patients with varying area of photodamage. The level of tenascin on adult skin is severely restricted but we had observed the increase on vitiligo skin lesions. Although it is uncertain that the increased tenascin expression is the cause or the result of disease, vitiligo and increased tenascin expression is thought to be related each other. This study has shown that tenascin increased on photodamaged vitiligo skin lesions. So we shoud consider choosing phototherapy to vitiligo.

유년기에 발생한 Porokeratotic eccrine ostial and dermal duct nevus 1 예

유한동 대한피부과학회 2000 대한피부과학회지 Vol.38 No.7

Porokeratotic eccrine ostial and dermal duct nevus is considered to be a rare congenital hamartoma of eccrine duct origin. Histopathologic studies showed multiple cornoid lamella-like parakeratotic columns, which were associated with hyperplastic eccrine ostia and distal sweat ducts. I describe the case of a 20-year-old man with childhood-onset porokeratotic eccrine ostial and dermal duct nevus. He had a 10-year history of multiple keratotic papules and comedo-like pits on the thenar area and thumb of the right hand. But in my case, immunohistochemical studies for carcinoembryonic antigen showed no association with eccrine ostium and adjacent cornoid lamella-like structures.

최근 4년간 대상포진으로 입원한 환자들에 대한 임상적 관찰(1995-1998)

유한동 凡石學術奬學財團 2000 凡石學術論文集 Vol.4 No.-