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朴徹勳,嚴柱五,柳深根,金哲源,金鍾桓,趙漢栢 대한한의학회 부인과학회 2001 大韓韓方婦人科學會誌 Vol.14 No.1
Osteoporosis is a disease characterized by bone loss and morbidity with osteoporotic fracture is increasing in elderly. The most common form of osteoporosis is that associated with deficiency of estrogen. Women rapidly lose additional skeletal bone mass in the years immediately after ovarian function stops. The rapid period of postmenopausal bone loss significantly increases the risk of clinical osteoporosis in women. The purpose of this study is to examine what are the effects of the Carthami Semen(CS) on the ovariectomized rat model of postmenopausal osteoporosis. The results of the experiment are as follows 1. Body weight in control group showed significant increase in comparison with sham, but that in CS-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham, but that in CS-treated showed no change in comparison with control. 3. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in CS-treated showed no change in comparison with control. 4. The level of serum phosphorus in control group showed significant increase in comparison with sham, but that in CS-treated showed no change in comparison with control. 5. The level of serum calcium in control group showed no change in comparison with sham, but that in CS-treated was significantly decreased in comparison with control. 6. The level of serum T_3 in control group showed no change in comparison with sham, but that in CS-treated was significantly decreased in comparison with control. 7. The level of serum T_4 in control group showed significant increase in comparison with sham, and that in CS-treated was significantly decreased in comparison with control. 8. Mechanical strength of the femur neck in control group showed significant decrease in comparison with sham, and that in CS-treated was significantly increased in comparison with control. According to the above these results, CS has shown to be capable of preventing and curing osteoporosis caused by and postmenopause.