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RISS 인기검색어
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- 저자 : 유석동(Seuck Dong Yoo) (검색결과 3 건)
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복수에서의 Carcinoembryonic Antigen 과 Alpha - Fetoprotein 에 관한 연구
유석동(Seuck Dong Yoo),강영진(Young Jin Kang),홍택종(Taek Jong Hong),박희욱(Hee Ug Park),김성은(Seong Eun Kim),최장락(Jang Rack Choi),조군제(Goon Jae Cho),양웅석(Ung Suk Yang),허윤(Yoon Huh) 대한내과학회 1988 대한내과학회지 Vol.35 No.2
N/A In order to determine whether carcinoembryonic antigen (CEA) & alpha-fetoprotein (AFP) in ascitic fluid assist in the diagnosis of malignant disease in abdominal cavity and their peritoneal metastasis, the authors studied 39 cases of malignant ascites patients (of which 19 cases were proven to be peritoneal metastasis) and 38 cases of nonmalignant ascites patients and analyzed the CEA 8z AFP levels of those cases from February, 1987 to August, 1987 in Pusan National University Hospital. The results obtained were as follows: 1) The CEA level of the malignant ascites group was significantly higher than that of the nonmaligant ascites group in ascitic fluid (p<0.005), but not significant in serum (p>0.05). 2) The AFP level of the malignant ascites group was significantly higher than that of the nonmaligant ascites group in ascitic fluid and serum (p<0.01; ascitic fluid, p<0.005; serum). 3) The CEA level of the hepatoma group was significantly lower than that of the non-hepatic malignant group in ascitic fluid and serum (p<0.005), but the AFP level of the hepatoma group was significantly higher only in ascitic fluid (p<0.005). 4) The AFP level of the hepatoma group was significantly higher than that of the liver cirrhosis group in ascitic fluid and serum (p<0.005) but the CEA level of the hepatoma group was significantly higher only in ascitic fluid (p<0.005). 5) Ascitic fluid and serum CEA levels were higher than the upper limit (4.37 ng/ml; ascitic fluid, 5.35 ng/ml; serum) in 15 of 39 of the cases in the malignant ascites group (38.5%), of which 11 eases proven to be peritoneal metastasis (8 cases of stomach Ca, 2 cases of pancreatic Ca, 1 case of colon Ca). 6) The specificity of ascitic fluid CEA for malignant diseases in the abdominal cavity was 86.8%, the positive predictability was 82.1%, the sensitivity was 59.0%, and the negative predictability was 67.3%. The specificity of serum CEA was 94.7/o, the positive predictability was 88.2%, the sensitivity was 38,5% and the negative predictability was 60.0%. 7) Ascitic fluid and serum AFP levels were higher than the upper limit (35.40 ng/ml; ascitic fluid, 43.02 ng/ ml; serum) in 14 of 39 of the cases in the of the cases in the malignant ascites group (35.9%), all of which were primary hepatoma out only 2 cases proven to be peritoneal metastasis. It was concluded that the measurement of ascitic fluid CEA & AFP levels is useful in determining the existence, peritoneal metastasis and differential diagnosis of malignant diseases in the abdominal cavity.
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인슐린 비의존형 당뇨병 환자의 혈청 C - peptide 농도와 혈당조절의 임상적 평가에 관한 연구
배상균(Sang Kyun Bae),김인주(In Ju Kim),박현(Hyun Park),유석동(Seuck Dong Yoo),김정완(Jung Wan Kim),김용기(Yong Ki Kim),김동수(Dong Soo Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.6
N/A To evaluate the clinical characteristics and relationships between the values of serum glucose, C-peptide and body mass index (BMI) in non-insulin dependent DM, we had investigated 28 cases of NIDDM who had admitted in Pusan National University Hospital from Mar. 1985 to Aug. 1986. The patients were divided into two groups according to postprandial serum insulin, C-peptide levels and therapeutic modalities: The following results were observed; 1) The BMI of the patients with postprandial value more than 30μU/ml for insulin (group I1) and 3.6ng/ml for C-peptide (group C1) was higher and Hb A1-C was lower than that of the patients with less values (group I2, C2), respectively. 2) Comparing the data in the group who were treated with oral hypoglycemics (glibenclamide), mean fasting and postprandial serum C-peptide levels were higher in responders than non responders, and the C-peptide/BMI scores were 15.8±5.5 vs 16.5±6.4 (p>0.05), C-peptide/Glucose score, 1.81±0.47 vs 1.02±0.37 (p<0.025); and Glucose/BMI score, 861±121 vs 1162±105 (p<0.01) in responders and non-responders, respectively. 3) Comparing the data in the group who were treated with insulin, the C-peptide/Glucose score were 13.5±4.3 vs 14.8±6.1 (p>0.05); C-peptide/Glucose score, 1.48±0.48 vs 0.88±0.35 (p<0.01); and C-peptide/BMI score, 945±227 vs 1588±139 (p<0.005) in responders and non-responders, respectively. 4) The responders in both group who were treated with oral hypoglycemics or insulin were characterized by C-peptide/Glucose score greater than 1 and C-peptide/BMI score less than 900 and the non-responders by C-peptide/Glucose score less than 1, and Glucose/BMI score greater than 900. These simple calculated indexes are practical and may serve for evaluating the glycemic control and determining the therapeutic modalities.
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