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한국인 집단에서 Y 염색체 상의 Alu(YAP)element 다형 현상 분석
김욱,유경화 한국유전학회 1996 Genes & Genomics Vol.18 No.1
A simple polymorphism resulting from the recent insertion of an Alu element, referred to as the Y Alu polymorphic (YAP) element, on the long arm (Yq 11) of the Y chromosome has been proved to be useful for the human population studies. We have examined the Y Alu insertion polymorphism using PCR based detection method in Korean population. A total of 204 unrelated males were analyzed to raise the possibility of tracing paternal lineages and male-mediated gene flow between Korea and Japan. The frequency of YAP element was found to be 0.98% (2/204). Therefore, almost Korean revealed to have YAF element (>99%) similar to those of most Asian populations with the exception of high frequency of YAP element in Japanese. We cloned these two Korean YAF elements derived from PCR products by ligating into pCR^(TM)II plasmids and subsequently sequenced to determine the Y haplotype based on the length of the 3'-terminal poly(A) region of the sequence. The first clone, designated p[YAP]KB1 appeared to have 41 dA-nucleotides and the second one, p[YAP]KK1 was found to have 50 dA-nucleotides. Based on these results, they seem to belong to the type 3a which is frequently found in Japanese population. It might be suggested that these YAP chromosomes provide an explanation for the admixture recently from Japan. Therefore the rate of admixture for YAP chromosomes from Japan to Korea appeared to be extremely low than that of a large infusion of YAP chromosomes with the Yayoi migration starting 2,300 years ago from Korea. Finally, all of these results support the hybridization theory that modern Japanese populations have resulted from the ancient Jomon people (YAP) and Yayoi immigrants (YAP) from Korea.