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3-(4-Methoxybenzylaminomethylene)-1,3-dihydroindole-2-one(5-108) 화합물의 항콕시디움 효과
여선주(Seon-Ju Yeo),김학성(Hak Sung Kim),김석(Suk Kim),이기인(Kee-In Lee),박현(Hyun Park) 대한약학회 2015 약학회지 Vol.59 No.6
Abstract—Coccidiosis is induced by Toxoplasma gondii and Eimeria tenella and novel anticoccidial drugs have been requested. In this study, the anticoccidial effect of 3-(4-methoxybenzylaminomethylene)-1,3-dihydroindole-2-one (5-108) on T. gondii and E. tenella was evaluated. Novel synthetic derivative 5-108 showed 1.44 fold higher relative selectivity compared to pyrimethamine against T. gondii in vitro assay. In chicken study, compound 5-108 significantly decreased the number of oocytes of E. tenella in feces, obtained from E. tenella-infected chickens, by 33±2.64% and 23±3.60% (P<0.001) at 7th day and 9th day p.i.. Conclusively, compound 5-108 was effective against T. gondii and E. tenella.
Microfluidic Generation of Graphene Bubbles for Ultralight, Strong, and Superelastic Materials
Seon Ju Yeo(여선주),Min Jun Oh(오민준),Hyun Min Jun(전현민),Minhwan Lee(이민환),Jung Gun Bae(배중건),Yeseul Kim(김예슬),Kyung Jin Park(박경진),Seungwoo Lee(이승우),Daeyeon Lee(이대연),Byung Mook Weon(원병묵),Won Bo Lee(이원보),Seok J 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.8