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엄정신,김영일,남용옥,양재헌 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-
In order to increase bioavailabilities of Scutellariae Radix extract(SRE), very slightly soluble in oil phases and sparingly soluble in water phases, the preparation of emulsification was attempted. In previously studies in O/W and W/O forms emulsion, the stabilities were evaluated for each forms. In this study, the dissolution and bioavailabilies of each emulsion preparation of SRE were compared. The dissolution pattern of SRE in W/O emulsion was decreased more than O/W emulsion in dilute hydrochloric acid solution(pH1.2) and in phosphate buffer solution(pH 6.8). The absorption velocity of baicalin from W/P emulsion was slower than O/W emulsion. The absorption velocity of baicalin in stomach was slower than in duodenum and jejunum of rats. The time required for the maximum serum concentration (C_max) of baicalin from water phase, oil phase, O/W and W/O emulsion in mice were 30. 60, 90, and 120 minutes after oral administration respectively. The C_max of baicalin from water phase, oil phase, O.W and W/O emulsion in mice were 2.11, 0.61, 1.57, and 1.35 ug/ml respectively. The longer was the time required for C_max, the lower was C_max. If the bioavailability to water phase is 100, the relative bioavailability(RB) to W/O emulsion is 129.14 The result suggests that the improvement of bioavailability for baicalin in W/O emulsion might be practically available.
Baicalin Emulsion의 제조조건 및 抗菌效果에 關한 硏究
엄정신,김영일,엄동옥,양재헌 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-
The emulsion of Scutellariae Radix was prepared following homogenizing with emulsifier between water phases and oil phases. This emulsion is two type, one is oil-in-water (O/W) emulsion and the other water-in-oil(W/O) emulsion. Scutellariae Radix extract(SRE) was very slightly soluble in oil phases and wparingly soluble in water phases. The lipid-water partition coefficients of SRE was high in chloroform, but was very low in other organic solvents. Emulsion was successfuly preparated under the various conditions and evaluated by microscopy. The partition coefficient of oil/water was also determinated. The viscosity of emulsion was increased more than water phase and oil phase, and the visicoty of W/O emulsion was hisher than O/W emulsion. The stability was higher in W/O emulsion than O/W emulsion.