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1 % Triclosan과 0 . 5 % 고삼추출물을 함유한 세안제의 여드름에 대한 효과
이남호 ( Nam Ho Lee ),최응호 ( Eung Ho Choi ),안성구 ( Sung Ku Ahn ),이승헌 ( Seung Hun Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5
Background: Acne is a relatively common disorder, especially in the adolescent. The condition is characterizecl by comedones, papules and pusi:ules. Acne patients frequently wash their face. Cleansing with an effective agent is therapeutic and preventive for patients suffering from acne vulgaris. Objeetive: The study was designed to compare thc efficacy and safety of a facial clemser consisting of 1% triclosan and 0.5% Ku Shen and a in in the treatment of facial acne vulgaris. Methods: The study was camed out on two groups of people : a treatment and a control group. Efficacy and safety were assessed at baseline and at weeks 1, 2, 3, 4, 6, 8, 10 and 12. Efficacy was determined by investigating counts of non-inflamatory open and closed comedones, and inflamatory papules and pustules. Global improvement was also assessed. Results : At week 12, the mean counts in the differe,nt lesions were as follows; 11.2 versus 17.2 for total lesions (p<0.05); 9.4 versus 11.3 for non-inflammatory lesions (p<0.05); 1.8 versus 5.9 for inflammatory lesions (p<0.05) in the treatment and control group, respectively. A Statistically significant difference was observed in patients overall self-assessment (p<0.05). The Group applying the facial cleanser with 1% triclosan and 0.5% Ku Shen felt significantly better than the one applying the control facial cleanser. Some patients developed mild and transient local side effects. Conclusian : Cleansing three times a day with a facial cleanser consisting of l% triclosan and 0.5% Ku Shen was found to be effective ancl safe for patients suffering from acne vulgaris. (Korean J Dermatol 1998;36(5): 871-876)
피부섬유종의 임상양상과 유병기간에 따른 병리조직학적 및 면역조직학적 고찰
안성구(Sung Ku Ahn),이남호(Nam Ho Lee),강윤철(Yun Chul Kang),최응호(Eung Ho Choi),황상민(Sang Min Hwang),이승헌(Seung Hun Lee) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.4
N/A Background:Dermatofibroma is a common benign fibrohistiocytic lesion that occurs most commonly on the legs of middle-aged women. Objective:The study was performed to evaluate the clinical, histopathological and immunohistochemical features of dermatofibromas according to the duration. Methods:Sixty seven cases of dermatofibromas were selected from 12 years of laboratory files for the period January 1986 to June 1998 from two medical hospitals. Results:1. The age range was from 10 to 69 and the average age at diagnosis was 36.0 (male;38.3, female;34.5). The ratio of male to female was 1.0:1.5 (27:40). 2. Fifty eight cases(86.5%) had solitary lesions, and nine cases(13.5%) had multiple lesions. 3. The lower extremities(40 cases, 50.6%) were the most common sites followed by the upper extremities(16 cases, 20.9%), abdomen(5 cases, 6.3%), shoulders(4 cases, 5.0%), back(3 cases, 3.7%), hands(3 cases, 3.7%), neck(2 cases, 2.5%), buttock(2 cases, 2.5%), breast(1 cases, 1.2%), face(1 cases, 1.2%), axilla(1 cases, 1.2%) and foot(1 cases, 1.2%). 4. The most common color was brown (50 cases, 74.7%), and other common colors were red(10 cases, 14.9%), black (4 cases, 5.9%), violaceous (3 cases, 4.5%). 5. Histopathologically, fibrous types were seen in 51cases(76.1%), cellular types in 6 cases (8.9%), mixed types in 7 cases(10.4%), and sclerosing hemangiomas in 3 cases(4.6%). 6. All lesions were positive for factor XIIIa. However, the degree of staining was different according to the duration; less than 1 year(10 cases-strong positive), between 1 to 5 years (3 cases-strong positive, 7 cases-moderate positive), more than 5 years(2 cases-moderate positive, 3 cases-weak positive). 7. Results of Masson's trichrome and Verhoeff-van Gieson stain showed that normal appearanced collagen and elastic fibers were increased in the lesion according to the duration and mucin depositions were also more increased in the old lesion than the younger lesion by alcian blue stain. Conclusion:On the basis of our result, we believe that factor XIIIa-positive cells seen in dermatofibroma represent reactive stromal cells rather than true tumor cells. Further studies are needed to determine whether the other factors are related to the pathogenesis of dermatofibroma. (Korean J Dermatol 2000;38(4):500~505)
이남호,최응호,이원수,안성구 ( Nam Ho Lee,Eung Ho Choi,Won Soo Lee,Sung Ku Ahn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Here we report a case of familial acanthosis nigricans. The patient was a 16-year-old boy, who had hyperpigmented, velvety plaques on both axillae for 5 years. His mother and sister had the same lesions on both axillae. On histopathological examination, we could observe hyperkeratosis, papillomatosis and irregular acanthosis of the epidermis and upward projection of dermal papillae in finger-like fashions. The patient, his mother and sister had no endocrinopathies or congenital abnormalities. (Kor J Dermatol l997;35(4): 802-804)
이남호,안성구,이원수,김중기,남인환,최응호,이인욱 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.1
Folliculosebaceous cystic hamartoma is a rare, benign condition. The histological criteria of folliculosebaceous cystic hamartoma have been well established by Kimura et al. We report two cases of folliculosebaceous cystic hamartoma which showed typical histological findings. As far as we know, it has not yet been reported in Korean dermatological literature. The first case is a 23-year-old man who had a pedunculated nodule on the scalp. The second one is a 46-year-old man who had a bean sized pedunculated nodule on the left cheek.
이남호,안성구,황상민,최응호,송동훈,이원수 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.11
Dermal melanocytosis is observed in various congenital conditions including nevus of Ota, nevus of Ito and Mongolian spot. It usually appears at birth or in early childhood. Several types of acquired dermal melanocytosis which usually appear in adult life have been reported. As the late onset has been stressed, the term acquired is used. We report two cases of acquired dermal melanocytosis on the forearm and the back without any similar pigmentation elsewhere on the body. The first case is a 47-year-old man who had numerous grey-blue colored macules and patches on the upper back. Histopathologic findings showed a large number of spindle-shaped cells containing melanin granules in the dermis. On electron microscopy, dermal melanocytes with stage 3, 4 melanosomes and lipid droplet were observed. The second one is a 13-year-old girl who had a 3.8 X 2.5 cm sized dark grey colored patch on the left forearm. Histopathologic and EM finding were similar to case 1. We treated both cases with topical cream(retinoid and hydroquinone), but could not observe improvement. Their lesions have persisted without any change.
이남호,안성구,황상민,최응호 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.5
We report a case of trichilemmal carcinoma in a 53-year-old man who presented a nodule on the left preauricular area. The past history revealed that there had been an asymptomatic brownish ulcerative nodule for 5 years. On histological examination, tumor cells showed PAS-positive cytoplasm and cytologic atypia with mitotic figures. Computerized tomography of the lesion showed tumor invasion into the left preauticular area. The patient was treated using a wide surgical excision. Fourteen months after the operntion, recurrence was not found.