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Diaminocyclohexane 을 배위자로 한 새로운 항암성 백금 (2) 착체류의 일반약리작용
고석태(Suk Tai Ko),강선영(Seon Yung Kang),임동윤(Dong Yoon Lim),신현준(Hyun June Shin),이승기(Seung Ki Lee),노영수(Young Soo Rho),정지창(Jee Chang Jung) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
The general pharmacological properties of new platinum (II) coordination complexes, SA : [Pt (trans-ℓ-DACH)(DPPE)]·2NO₃, SB : [Pt(cis-DACH)(DPPP)] ·2NO₃ and SC : [Pt(cis-DACH)(DPPE)] ·2NO₃ on central nervous, respiratory, cardiovascular and digestive systems were studied in various experimental animals. These platinum (II) anticancer agents had no effects on analgesia, thiopental-induced sleeping time, body temperature, strychnine-induced convulsion, inflammation and local anesthetic action in mice and rats. Intestinal motility, stomach-ulcer induced by serotonin and bile-secretion of rats were not influenced by the dose of 30 ㎎/㎏. However SB and SC induced a mild decrease in heart rate in anesthetized rats. Based on these results, these new platinum (II) complexes may be regarded as a valuable lead compound in the development of new anticancer chemotherapeutic agents with marked antitumor activity and low toxicity.