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질산염이 다량 축적된 Italian ryegrass 급여에 따른 면양의 혈액중 Methemoglobin 농도의 경시적 변화
윤창,전우복,송명희 ( C . Yoon,W . B . Chun,M . H . Song ) 한국축산학회 1989 한국축산학회지 Vol.31 No.12
This study was conducted to investigate the influence of nitrate accumulation in Italian ryegrass feeding on the change of methemoglobin and hemoglobin in sheep. 12 Corriedale wethers(average body weight 33kg) were fed Italian ryegrass containing average 0.469% N0₃ N. Blood samples were taken at l hour before feeding and 4, 5, 6, 7, 8, 9, 10 hours after feeding, and then hemoglobin and methemoglobin concentration in blood were determined. The results obtained were summerized as follows ; 1. No significant difference was observed in the changing pattern of hemoglobin concentration in blood. 2. There were large variations among the test animals in the capacity of methemoglobin formation of the Italian ryegrass feeding.
L - NAME 에 의한 쥐의 발바닥에서 Freund's Complete Adjuvant 에 의해 유발된 통증 억제
이 청(Cheong Lee),최 윤(Yoon Choi),송명희(Myung He 대한통증학회 1998 The Korean Journal of Pain Vol.11 No.2
N/A Background: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. We attempted to find out the peripheral effects of nitric oxide (NO) on hyperalgesia induced by Freund's eomplete adjuvant (FCA) induced inflammation. Methods: Male Sprague Dawley rats were divided into three groups; control, low dose NG-nitro- L-arginine methyl ester (L-NAME, 500 ug), high dose L-NAME (5 mg). Inflammation was induced by injecting 0.l ml of PCA intraplantarly, which shows typical hyperalgesia within twelve hours after injec- tion and maintamed for about one week. Drugs were injected 2 hours before, just before, and 3, 6, 9, 12 hours after the injection of FCA. Effect of L-NAME on hyperalgesia was assessed by measuring mechanical hyperalgesia and spontaneous pain for 3 days. Results: When injected at the site of inflammation, L-NAME caused dose dependent reduction of sponlaneous hyperalgesia. Mechanical hyperalgesia was also reduced by high dose L-NAME (p<0.05). After syslemic injection of high dose L-NAME in the back, no significant difference was noticed. Conclusions: This suggest that L-NAME reduces FCA induced hyperalgesia via peripheral action.