국내 건축설계사무소의 건축정보이용 및 정보화 실태에 관한 조사연구

손재원,윤춘섭 대한건축학회 1998 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.18 No.2

Application of isothermal chemical denaturation to early‐stage formulation development of fibrinogen

손재원,Jong Mun Son,Ki Ho Hur,이원화,송임숙,나동희 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.4

The purpose of this study was to develop fibrinogen formulation using isother- mal chemical denaturation (ICD), which is a technique that measures the con- formational stability of proteins through structure perturbation by denaturants such as urea. Fibrinogen has been used to treat various congenital and acquired human fibrinogen-related disorders that represent a group of rare conditions. In this study, 10 formulations of fibrinogen were initially prepared and appropriate formulations were screened via automated, high-throughput ICD measurements. The optimal formulation selection process was further per- formed through osmolality measurements and accelerated stability study at 40 C and 75% relative humidity. The fibrinogen formulation was optimized with 20 mg/ml fibrinogen, 16 mg/ml L-arginine, 10 mg/ml glycine, 1.2 mg/ml tri-sodium citrate dihydrate, and 3.5 mg/ml sodium chloride at pH 7.0. This study demonstrates that ICD-based formulation screening approach is highly applicable to early-stage formulation development of fibrinogen.

국내 종합병원 외래진료부의 최근 건축경향에 관한 연구

손재원,이특구 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.2

Much has changed in the healthcare field since the beginning of the industrial age. In the healthcare field changes are occurring so rapidly and dramatically that yesterday’s paradigm will not be tomorrow’s paradigm, creating the need above all else to stay fluid and flexible as strategies(included healthcare architecture planning) for the future are developed. The purpose of this study is to analyze the latest architectural trends of general hospital outpatient department based on the healthcare environment changes in Korea. The major healthcare environment change is to change the object of hospital’s healthcare services from inpatient to outpatient. In conclusion, the first, medical faculties of outpatient department are subdivided specialized small faculty. The second, clinic systems for medical examination and treatment of specific disease are activated in the most outpatient department, The third, specialized medical centers for chronical disease(Cancer, Cardiac etc.) control are arranged in existed outpatient department or freestanding facility. Specialized medical center for preventive medicine is regionally decentralized for corresponding with the healthcare paradigm shifts.

광범위특발성 폐신경내분비세포 과증식으로 오인된 뇌하수체 거대선종에 의한 쿠싱병 1예

손재원,전지은,황유철,안규정,정호연,정인경 대한내과학회 2021 대한내과학회 추계학술대회 Vol.2021 No.1

실버타운의 입지별 유형에 따른 공간구성의 문제점과 개선방향에 관한 연구

손재원,한기증,이특구 한국의료복지시설학회 2001 의료·복지 건축 Vol.7 No.1

The purpose of this study is to suggest the improvement directions and conditions of spacial composition according to location style of silver towns. The spacial composition of silver town used in 3 cases are analyzed according to their location(the urban type, the sub-urban type and the resort type). The points of analysis are focused on the necessary spaces and selectable spaces related to location of silver towns. In conclusion, the urban and sub-urban silver towns should have the necessary spaces and selectable spaces through analysis of the spaces in healthcare facilities near at hand. The resort silver towns should be planned to harmony the functional spaces with building shapes because they consist of various spaces.

국내 종합병원 외래진료부의 최근 건축경향에 관한 연구

손재원,이특구 한국의료복지건축학회 2006 의료·복지 건축 Vol.12 No.2

Much has changed in the healthcare field since the beginning of the industrial age. In the healthcare field changes are occurring so rapidly and dramatically that yesterday's paradigm will not be tomorrow's paradigm, creating the need above all else to stay fluid and flexible as strategies(included healthcare architecture planning) for the future are developed. The purpose of this study is to analyze the latest architectural trends of general hospital outpatient department based on the healthcare environment changes in Korea. The major healthcare environment change is to change the object of hospital's healthcare services from inpatient to outpatient.In conclusion, the first, medical faculties of outpatient department are subdivided specialized small faculty. The second, clinic systems for medical examination and treatment of specific disease are activated in the most outpatient department. The third, specialized medical centers for chronical disease(Cancer, Cardiac etc.) control are arranged in existed outpatient department or freestanding facility. Specialized medical center for preventive medicine is regionally decentralized for corresponding with the healthcare paradigm shifts.

국내 종합병원 외래진료부의 공간변화에 관한 조사연구

손재원,이특구 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.3

Nowadays, it has been changed in medical environments which are the increase of the aged and chronic disease, development of medical system and technology, the open of medical markets according to negotiation of DDA(Doha Development Agenda) and FTA(Free Trade Agreement) and so on. The changes of medical system and function are caused by changes of medical environments, This study is to analyze the spatial changes of general hospital O. P. D. in Korea based on changes of the medical system and function. In conclusion, the O. P. D. in general hospital has been changed by stages as follows; First, subdivision and specialization of medical organization systems. Second, diversification of specialized centers based on medical cooperated systems. At last, integration of E&T faculties and specialized centers which have similar functions. According to the spatial changes of outpatient department, the types of E&T faculties and specialized centers has been changed by diverse forms as follows; E&T faculties and specialized centers focused on disease, organs, classes and so on.

종합병원 외래진료부의 공간구성과 규모계획에 관한 조사연구 : 최근 계획된 500병상 이상 규모의 종합병원을 중심으로

손재원,이특구 한국의료복지시설학회 2007 의료·복지 건축 Vol.13 No.2

Various changes in medical environments including growing elderly population, chronic diseases, deepening competition among hospitals since opening to foreign medical service, economic strategy for improvement of profit system have caused hospitals to be specialized. In this backgrounds, the purpose of this study is to receive basic data for architectural planning on the spatial organization of outpatient department in general hospital. The results of this study were as follows; First, major changes of outpatient department in general hospital are composed of 'co-work in medical examination and treatment', 'decentralization of diagnosis and treatment(D/T)' and 'patient-oriented medical service'. Changes by co-work system include appearance of medical offices for co-work, activation of specialized clinics, grouping of E/T section for outpatient and various types of specialized centers. Second, the grouping of E/T sections means the modification of E/T system and organization in general hospitals, and a new spatial organization will be needed. Third, the types of specialized centers are getting varied. they are classified into several types including disease-resource, social stratum-resource, human organ-resource, health-resource, rehabilitation-resource, alternative medical center and so on.

Asphalt Bond Strength를 이용한 아스팔트 포장의 수분민감도 평가

손재원,손정탄 한국도로학회 2017 한국도로학회 학술대회 발표논문 초록집 Vol.2017 No.10

최근 여름철 집중호우 및 폭염지속, 겨울철 폭설 등 이상기후 와 2000년대 들어 버스전용차선이 본격적으로 시행되고 차량하중의 중량화로 인한 직․간접적인 요인으로 인하여 도로파손이 가속화 되고 있다. 서울특별시의 포트홀(Pothole) 발생 현황을 살펴보면 2006년도에는 3만 8천 건에서 2010년도에는 7만 7천 건으로 두 배 이상 급증하였다(서울연구원 2012). 수분손상(Moisture Damage)및 박리(Stripping)현상은 강수에 의한 수분의 침투로 아스팔트 피막과 골재사이의 접착력을 약화시키고 이는 도로의 강성과 내구성의 손실로 도로파손이 빈번히 발생하게 되며 도로자체의 구조적 문제적인 문제까지 야기시키게 된다. 제안된 문제들의 해결을 위한 첫 걸음으로 아스팔트 혼합물의 수분에 대한 저항성을 객관적으로 보다 손쉽게 평가할 수 있는 실험법이 필요한 실정이다. 이에 본 연구에서는 AASHTO TP – 91에 규정되어 있는 ABS(Asphalt Bond Strength) Test를 이용하여 수분 손상에 따른 골재와 아스팔트 바인더와의 접착 특성을 평가하고 이를 AASHTO T 283에서 제시하고 있는 아스팔트 혼합물의 수분민감도 평가 방법인 인장강도 비(Tensile Strength Ratio, TSR) 시험 방법과 비교 평가하여 수분 손상에 따른 골재와 아스팔트 바인더와의 접착 특성이 아스팔트 혼합물의 강도 특성에 미치는 영향을 평가하였다. 상기 그림에서와 같이 아스팔트 점착 강도 시험은 간단한 시험시편 제작과 시험조건으로 손쉽게 수분 손상을 평가할 수 있으며, 분석방법 역시 골재와 아스팔트 바인더 사이에서의 강도 변화를 직접적으로 측정할 수 있어 실험 결과에 대한 신뢰성이 높은 장점을 가진다. 수분 손상에 따른 골재와 아스팔트 바인더의 점착력 변화와 아스팔트 혼합물의 강도 변화를 비교 평가한 결과, 두 평가방법이 상호간의 상당히 높은 상관관계를 나타내었으며, 골재와 아스팔트 바인더와의 점착력을 이용하여 아스팔트 혼합물의 수분 손상 대한 평가 기준 제시(품질기준)가 가능할 것으로 판단된다. 다만, 본 연구에서는 재료의 품질 특성 평가만을 수행하였기 때문에 수분 손상에 대한 아스팔트 혼합물의 구조적 특성 등을 평가하여 실제 포장의 공용수명에 미치는 영향 등에 대하여 추가적인 연구가 수행되어야 할 것으로 판단된다.

국내 종합병원 외래진료부의 유형별 특성과 공간구성에 관한 연구

손재원,이특구 대한건축학회 2006 대한건축학회논문집 Vol.22 No.10

This study is to analyze the spatial composition and characteristics by types of general hospital O. P. D. in Korea.In conclusion, first, the general hospital O. P. D is able to classify into the types focused on spatial configuration, plot planning, floor plan and corridor shape. Each types are changed by corresponding with examination & treatment(E&T) systems and functions of O. P. D. in general hospital.Second, the types of E&T department are able to classify into the singleness department and grouped department composed by several faculties. The grouped E&T department is subdivided into room units E&T and section units E&T by bonded types.Third, the types of specialized center are able to classify into general center, centers for chronic disease, peoples of specific class(child, woman, elderly etc.), internal organ, health promotion, rehabilitation and so on.