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손영택,김기수,Sohn, Young-Taek,Kim, Ki-Soo 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.2
Five crystalline forms of cimetidine, four anhydrous and a monohydrate, have been prepared, and their thermal behavriours have been studied by differential thermal analysis and thermo-gravimetry. The dissolution rates of the five forms were determined in distilled water at $37^{\circ}C$. The results showed a significant difference in the dissolution rate. Polymorphic transformation occurred spontaneously during storage at room condition and was accelerated by applied energy during formulation process-milling.
손영택(Young Taek Sohn) 대한약학회 1996 약학회지 Vol.40 No.5
The polymorphism of piroxicam was studied. Form I, II, III and monohydrate designated as Form IX were prepared by recrystallization from different solvents. Depending on the cooling rate of the piroxicam melt, Form IV, V, VI, VII and VIII were prepared. The crystal forms were characterized by DTA, TGA and UV spectroscopy. Their dissolution patterns were also investigated. During storage at ambient condition. Form VIII was transformed into Form I and it was accelerated by milling. The other crystal forms were also transformed into Form I by milling. Form I and Form IX were very stable.
결정다형이 아목시실린의 상대적 생체이용률에 미치는 영향
손영택(Young Taek Sohn) 대한약학회 1995 약학회지 Vol.39 No.4
Four different pseudopolymorphs of amoxicilline-trihydrate, dihydrate, monohydrate and anhydrate were prepared and characterized by UV spectrophotometry, DSC, and TGA. In vitro dissolution studies of four pseudopolymorphs were carried out in pH 6.8 phosphate buffer at 37oC by means of a rotating disk method. The effect of four pseudopolymorphs on bioavailability of amoxicillin was studied in healthy 6 subjects using urinary excretion method. The dissolution result was shown in the sequence, trihydrate(95.5%)>monohydrate(83.5%)>anhydrate(67.6%)>dihydrate(15.8%). The urinary excretion rate of anhydrate could not be detected and the dissolution results agreed well with in vivo pharmacokinetic study results. The effects of storage, conditions, milling and compression on the pseudopolymorphic transformation were investigated by thermal methods. The results showed that four pseudopolymorphs were not transformed and they were very stable.
손영택(Young Taek Sohn),전임작(Im Jak Jeon) 한국약제학회 2000 Journal of Pharmaceutical Investigation Vol.30 No.3
Three new polymorphic modifications were prepared by recrystallization under various conditions and characterized by DSC and X-ray crystallography. In pH 4.0 buffer at 37±0.5℃, the polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 4, amorphous form, was faster than that of marketed cefaclor (Mod. 1). When all modifications were stored at 52% RH, 95% RH and in silicagel desiccator, any polymorphic transformation was not observed.
세파로틴 나트륨의 결정형이 용출과 안정성에 미치는 영향
손영택(Young Taek Sohn),박선희(Sun Hee Park) 대한약학회 1997 약학회지 Vol.41 No.3
Investigation of polymorphism has become a requirement in the pharmaceutical industry because the physical properties and bioavailabilities of crystalline drugs depend on their polymorphic form. Five polymorphic modifications and one pseudopolymorphic modification of ecphalothin sodium were prepared by recrystallization, and characterized by UV spectrophotometer, DSC, TGA and X-ray crystallography. The solubilities of all modifications were examined by the disslution test. Form 2 and 1 showed higher solubilities than any other crystal forms. The modifications were also investigated for their stability after storage of 2 months at 100%, 76%, 52% and 0% humidity.
손영택(Young Taek Sohn),정신희(Shin Hee Jung) 대한약학회 1996 약학회지 Vol.40 No.4
Five crystal modification of droperidol were prepared by recrystallization. They were characterized by UV spectrophotometer, DSC, and X-ray crystallography. Their dissolution patterns were also investigated. After storage of 2 months at 100% humidity, all polymorphic modifications were transformed.
손영택(Young Taek Sohn),김희경(Hee Kyung Kim) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.2
N/A Three polymorphic modifications and two pseudopolymorphic modifications of cefotaxime sodium were obtained by crystallization from different organic solvents. The isolated crystal forms were characterized by UV spectrophotometry, DSC, TGA and X-ray crystallography. Crystal forms of cefotaxime sodium were also compared by dissolution rate. The dissolution rate of form 1 was the highest, followed by form 2, form 4, form 6, form 5 and form 3. Among these polymorphic modifications the dissolution rate of form 3 and form 5 was much slower than that of cefotaxime sodium on the market. All forms showed no change after 2-month. storage test in the silica gel desiccator. But after the storage of 2-month at 95% relative humidity condition, all forms were deliquesced by hygroscopic property except form 1, that showed the highest dissolution rate. At 52% relative humidity condition, form 1, form 2 and form 6 had no evidence of phase transformation, but form 3, form 4 and form 5 were also deliquesced.
손영택(Young Taek Sohn),전혜련(He Ryun Chun) 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2
N/A Six polymorphic modifications of Balofloxacin (Q-35) were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD). The dissolution patterns of these six modifications were also checked in distilled water at 37±0.5℃, 50 rpm for 60 minutes. The polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 1 was faster than that of other polymorphic modifications. The transformation during storage was also studied.
손영택(Young Taek Sohn),김지선(Ji Seon Kim) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.2
N/A Five polymorphic modifications of Cephradin were prepared by recrystallization from organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray crystallography powder diffractometry. Modificaition 1 was the most stable form and decomposed at 201.3℃. Modification 3 and 4 were metastable. The dissolution of modification 3 and 4 was faster than that of marketed form.