내시경상 십이지장을 침범한 Henoch-Sch$\"{o}$nlein Purpura 환아의 임상적 특징

박선희,남유니,박상희,심소연,은병욱,최덕영,선용한,조강호,류일,손동우,전인상,차한,Park, Sun-Hee,Nam, Yoo-Nee,Park, Sang-Hui,Sim, So-Yeon,Eun, Byung-Wook,Choi, Deok-Young,Sun, Yong-Han,Cho, Kang-Ho,Ryoo, Eell,Son, Dong-Woo,Jeon, In-Sang 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.2

목 적: HSP 환아들의 상부 위장관 내시경 소견 및 병리 조직학적 소견에 대한 연구는 미미한 실정이다. 이에 저자들은 HSP 환아들의 상부 위장관 내시경 소견과 더불어 병리조직학적 소견 및 임상 양상들을 조사해 보고 그 임상적 유용성에 대해 살펴보고자 하였다. 방 법: 2002년 1월부터 2009년 6월까지 가천의대 길병원 소아청소년과에서 HSP로 진단받은 환아 중 입원하여 상부 위장관 내시경을 시행 받은 경우를 대상으로 의무 기록을 통한 후향적 연구를 시행하여 내시경 소견과 조직 검사 소견을 조사하였고, 내시경 시행 당시의 연령과 성별, 증상, 입원 기간, 재발 유무와 스테로이드 사용 여부, 검사실 검사 소견, H. pylori 감염 여부 등도조사하였다. 또한 내시경 소견 상 십이지장에 병변이 있는 군과 없는 군으로 나누어 검사실 검사 소견, 스테로이드 사용, 재원 일수, 복통의 지속 기간, 재발 유무등에 어떤 차이가 있는지 살펴보고자 하였다. 결 과: 1) HSP 환아에서 내시경을 시행한 경우는 총 51명(14.3%)이었고 연간 평균 시행 건수는 6.4${\pm}$2.8회였다. 상부 위장관 내시경을 가장 많이 시행 받은 연령은 5세였고 계절별로는 봄(3~5월)이 16명(31.4%)으로 시행 수가 가장 많았다. 모든 환아에서 복통이 관찰되었고 그 외의 위장관 증상으로 구토가 15명(29.4%), 혈변 7명(13.7%), 설사 7명(13.7%), 흑변 3명(5.6%) 등도 나타났다. 2) 상부 위장관 내시경 검사는 51예 중 38예(74.5%)에서 십이지장의 병변을 보이고 있었고 이 중 22예 (43.1%)에서 십이지장 궤양이 관찰되었다. 조직 검사를 시행한 37예 중 13예(35.1%)에서 십이지장 조직 소견이 HSP에 부합하는 것으로 판단되었다. 3) 검사실 검사 소견에서는 특이할 만한 점이 없었다. 4) 스테로이드 치료는 십이지장에 병변이 있는 38명중 33명(86.8%)에서, 병변이 없는 13명 중 7명(53.8%)에서 시행되었다(p=0.02). 평균 재원 일수는 십이지장에 병변이 있는 군에서 13.9${\pm}$8.43일, 병변이 없는 군에서 8.1${\pm}$4.62일이었다(p=0.003). 재발과 발병 시 나이, 신장 침범, 스테로이드 사용은 유의한 관계가 없었으나 십이지장 병변이 있는 경우 재발이 유의하게 감소하는 결과를 보였다(p=0.027). 결 론: HSP 환아에서, 상부 위장관 내시경 소견 상십이지장 궤양 등 십이지장의 병변이 높은 비율로 나타났고, 십이지장 병변이 있는 경우 스테로이드 사용과 재원 일수가 증가하였으나 복통의 지속기간이나 검사실 소견에서는 병변이 없는 군과 유의한 차이가 없었고 재발률은 오히려 낮게 나타났다. 십이지장 침범이 HSP의 경과와 예후에 어떠한 영향을 주는지에 관해 지속적인 연구가 필요할 것이다. Purpose: The aim of this study was to investigate the clinical usefulness of upper gastrointestinal (GI) endoscopy in children with Henoch-Sch$\"{o}$nlein purpura (HSP). Methods: We retrospectively analyzed the clinical, endoscopic, and histopathologic records of children with HSP who had been admitted to the Department of Pediatrics of Gil Hospital and underwent upper GI endoscopy between January 2002 and June 2009. Patients were classified into the following two groups for statistical analysis: duodenal involvement (+) and duodenal involvement (-). Results: Fifty-one children with HSP underwent upper GI endoscopy; the mean age was 7.2${\pm}$2.9 years. The upper GI endoscopy showed abnormalities of the duodenum in 38 cases (74.5%), 22 of which had duodenal ulcers. Among the biopsy specimens obtained from the duodenum of 37 cases, 13 cases (35.1%) had leukocytoclastic vasculitis, neutrophil debri, and/or extravasation of RBCs. Steroid use was more frequent in the duodenal involvement (+) group (86.8%) than the duodenal involvement (-) group (53.8%; p=0.02). The mean length of hospitalization was 13.9${\pm}$8.43 days in the duodenal involvement (+) group and 8.1${\pm}$4.62 days in the duodenal involvement (-) group (p=0.003). The recurrence rate was significantly higher in the duodenal involvement (-) group than the duodenal involvement (+) group (p=0.027), whereas none of the other study parameters, such as the age of onset, renal involvement, and steroid use, led to significantly higher or lower recurrence rates. Conclusion: These results suggest that duodenal involvement can influence the clinical course and prognosis of HSP in children.

수종(數種) 근관충진재(根管充眞材)의 근관폐쇄성(根管閉?性)에 관(關)한 실험적(實驗的) 연구(硏究)

박선희,민병순,최호영,박상진,Park, Sun-Hee,Min, Byung-Soon,Choi, Ho-Young,Park, Sang-Jin 대한치과보존학회 1988 Restorative Dentistry & Endodontics Vol.13 No.1

The purpose of this study was to evaluate and compare the sealing ability of ZOE, FR and AH-26. Seventy two upper and lower anterior and premolor teeth were randomly selected and instrumented in a conventional method with K-file. After instrumentation and dry the canal, the teeth were divided into 3 groups and twenty four teeth in each group were filled with ZOE, FR, and AH-26 respectively. All the specimens were immersed into Indian Ink and decalcified in nitric acid and cleared in methyl salicylate. The apical leakage was evaluated by measuring the degree of ink penetration with caliper at the intervals of 1 day, 7 days and 14 days. The results were as follows; 1. In AH-26 and FR groups, there was increase in penetration related to increased time of immersion in the ink. 2. FR group showed the least penetration in 3 groups. 3. Statistics showed that there was no significant difference among the each sealer groups.

Cu 머쉬룸 범프를 적용한 플립칩 접속부의 접속저항

박선희,오태성,Park, Sun-Hee,Oh, Tae-Sung 한국마이크로전자및패키징학회 2008 마이크로전자 및 패키징학회지 Vol.15 No.3

전기도금법으로 Cu 머쉬룸 범프를 형성하고 Sn 기판 패드에 플립칩 본딩하여 Cu 머쉬룸 범프 접속부를 형성하였으며, 이의 접속저항을 Sn planar 범프 접속부와 비교하였다. $19.1\sim95.2$ MPa 범위의 본딩응력으로 형성한 Cu머쉬룸 범프 접속부는 $15m\Omega$/bump의 평균 접속저항을 나타내었다. Cu머쉬룸 범프 접속부는 Sn planar범프 접속부에 비해 더 우수한 접속저항 특성을 나타내었다. 캡 표면에 $1{\sim}w4{\mu}m$ 두께의 Sn 코팅층을 전기도금한 Cu 머쉬룸 범프 접속부의 접속저항은 Sn 코팅층의 두께에 무관하였으나 캡 표면의 Sn코팅층을 리플로우 처리한 Cu머쉬룸 범프 접속부에서는 접속저항이 Sn 코팅층의 두께와 리플로우 시간에 크게 의존하였다. Cu mushroom bumps were formed by electrodeposition and flip-chip bonded to Sn substrate pads. Contact resistances of the Cu-mushroom-bump joints were measured and compared with those of the Sn-planar-bump joints. The Cu-mushroom-bump joints, processed at bonding stresses ranging from 19.1 to 95.2 MPa, exhibited contact resistances near $15m\Omega$/bump. Superior contact-resistance characteristics to those of the Sn-planar-bump joints were obtained with the Cu-mushroom-bump joints. Contact resistance of the Cu-mushroom-bump joints was not dependent upon the thickness of the as-elecroplated Sn-capcoating layer ranging from $1{\mu}m$ to $4{\mu}m$. When the Sn-cap-coating layer was reflowed, however, the contact resistance was greatly affected by the thickness and the reflow time of the Sn-cap-coating layer.

Under Bump Metallurgy의 종류와 리플로우 시간에 따른 Sn 솔더 계면반응

박선희,오태성,Park, Sun-Hee,Oh, Tae-Sung,Englemann, G. 한국마이크로전자및패키징학회 2007 마이크로전자 및 패키징학회지 Vol.14 No.3

웨이퍼 레벨 솔더범핑시 under bump metallurgy (UBM)의 종류와 리플로우 시간에 따른 Sn 솔더범프의 평균 금속간화합물 층의 두께와 UBM의 소모속도를 분석하였다. Cu UBM의 경우에는 리플로우 이전에 $0.6\;{\mu}m$ 두께의 금속간화합물 층이 형성되어 있었으며, $250^{\circ}C$에서 450초 동안 리플로우함에 따라 금속간화합물 층의 두께가 $4\;{\mu}m$으로 급격히 증가하였다. 이에 반해 Ni UBM에서는 리플로우 이전에 $0.2\;{\mu}m$ 두께의 금속간화합물 층이 형성되었으며, 450초 리플로우에 의해 금속간화합물의 두께가 $1.7\;{\mu}m$으로 증가하였다. Cu UBM의 소모속도는 15초 리플로우시에는 100 nm/sec, 450초 리플로우시에는 4.5 nm/sec이었으나, Ni UBM에서는 소모속도가 15초 리플로우시에는 28.7 nm/sec, 450초 리플로우시에는 1.82 nm/sec로 감소하였다. Thickness of intermetallic compounds and consumption rates of under bump metallurgies (UBMs) were investigated in wafer-level solder bumping with variations of UBM materials and reflow times. In the case of Cu UBM, $0.6\;{\mu}m-thick$ intermetallic compound layer was formed before reflow of Sn solder, and the average thickness of the intermetallic compound layer increased to $4\;{\mu}m$ by reflowing at $250^{\circ}C$ for 450 sec. On the contrary, the intermetallic layer had a thickness of $0.2\;{\mu}m$ on Ni UBM before reflow and it grew to $1.7\;{\mu}m$ thickness with reflowing for 450 sec. While the consumption rates of Cu UBM were 100nm/sec fur 15-sec reflow and 4.50-sec for 450-sec reflow, those of Ni UBM decreased to 28.7 nm/sec for 15-sec reflow and 1.82 nm/sec for 450-sec reflow.

기관이용노인의 관계적 공격성 경험에 관한 연구 -Colaizzi의 방법론을 중심으로 한 융합방법론 접근-

박선희,Park, Sun-Hee 한국사물인터넷학회 2020 한국사물인터넷학회 논문지 Vol.6 No.3

본 연구는 기관이용노인의 관계적 공격성 경험을 깊이 있게 탐색하고, 그 경험이 갖는 의미를 이해하는데 목적이 있다. 기관이용노인의 관계적 공격성 경험과 관련하여 노인은 '무엇'을 경험하였으며, '어떻게' 경험하였는지를 구조적인 기술로 발전시켜 '경험의 본질'을 알아보고자 하는 것이다. 부산시 기관이용노인 중 관계적 공격성 경험이 있는 노인 7명을 대상으로 비구조화된 질문지를 바탕으로 심층 면담을 수행하였다. Colaizzi의 현상학적 접근으로 분석한 결과 최종적으로 구성된 의미는 32개였고, 이를 다시 16개의 주제와 5개의 범주로 나타내었다. 5개의 범주로는 '힘없는 나'., '무인도에 있는 나', '내마음의 회오리', '세상속으로 보내는 나', '꺼져가는 나'로 분석하였다. 이러한 분석결과를 바탕으로 노인의 관계적 공격성 예방을 위한 실천적 제언을 제시하였다. The purpose of this study was to explore the experience of relational aggression that old users of institutions for seniors have, understanding what that experience means. In detail, the study tried to determine the nature of the experience through a structural description of what and how the elderly users experience relational aggression. For the purpose, this study made profound interviews with 7 elderly persons who sustained such aggression while using the seniors' institution in Busan. In the interview, a non-structured questionnaire survey was conducted. Data were analyzed using Colaizzi's phenomenological approach. As a result, the study identified 32 meanings of relational the experience which were in turn divided into 16 subjects, and 5 categories like 'I who am powerless', 'I who am in an unmanned island', 'whirlwinds in my mind', 'I who send myself into the world' and 'I who am dwindling'. Based on this result, this research made practical suggestions for preventing relational aggression as mentioned above.

조선시대 반가의 식사.취사생활과 공간사용

박선희,Park, Sun-Hee 한국건축역사학회 1992 건축역사연구 Vol.1 No.2

Eating was done on a respective one-man dining table, which reflect the esteem for the individual. The family eating place was generally An-bang of the house, The eating space of Yang-ban housing with its hierarchical, spatial method of tabling and eating around the head of the family served as a synchronically meaningful space which was to strengthen the solidarity of patriarchy beyond the mere funtioning place of eating. That meaning seems to reveal itself more conspicuously when we consider that the eating place is An-bang, the center of the main house. The basic space for cooking was Bu-oak (Chung-ji). Thre was no water-supply system or drainage in the kitchen, so all the water needed for cooking was drawn from outdoor well with a bucket. The traditional eating habits, the entertainment for the bustling guests, and the frequent sacrificial rites required many store rooms for the subasidiary food and wide space for putting food into order.

전통적(傳統的) 주거(住居)에서의 공간사용(空間使用)과 구성(構成)에 대한 한(韓).일(日)간의 비교(比較)(1) -강호시대(江戶時代) 무가(武家) 주택(住宅)의 공간적(空間的) 특질(特質)-

박선희,Park, Sun-Hee 한국건축역사학회 1994 건축역사연구 Vol.3 No.2

The major characteristics of warrior houses in Edo period were as follows: (1)The disposition, size, and facilities of warrior houses was to be settled strictly according to the social position. (2)The spatial characteristics of warrior houses has conceptual o-rganization of dual structure, such as entertainment/daily life, high/low, outside/inside.

반(反)성폭력 관점에서 본 친고죄

박선희,채종민,Park, Sun-Hee,Chae, Jong-Min 대한수사과학회 2006 대한수사과학회지 Vol.1 No.1

The definition of Crime Indictable Upon Complaint (CIC) is crimes which can be prosecuted only with complaints from the victim or his/her direct parents. Sex crimes are the representative examples, rapes and indecent assaults. According to the research referenced in this paper, 74% of sex crimes which had been penalized based on Republic of Korea (ROK) Criminal Code amounts rape and indecent assault are CIC. However, only 20% of perpetrators were confined, and the rest received non-confinement or non-prosecution determination. The review of criminal history checks reveals that 67% of the perpetrators had criminal histories and 39% of them had more than three documented offenses. The CIC was established in order to protect the victim's rights and dignity, respecting the victim's opinion regarding the incident. All kinds of sex crimes then should have been the CIC, but those crimes such as Injury Resulting from Rape, Special Rape, Rape by Special Modus Operandi, Sexual Assault among Relatives and Domestic Violence which have to guarantee the opinion of the victims are prescribed as non-CIC. We therefore conclude that the CIC should be abolished. The abolition of CIC will play an important role in crime prevention because severe penalties for sex crimes will be imposed on the perpetrators. In addition, it will help the sex crime victims retrieve their dignity by spreading recognition widely through the community that sexual assault is not only a social assault but an infringement against human rights.

구술로 본 1970년대 이후 전주지역 단독주택 부엌의 변화

박선희,Park, Sun-Hee 한국주거학회 2006 한국주거학회 논문집 Vol.17 No.6

The purpose of this study is to investigate the change of kitchen in a single detached house in Jeonju city after 70's. Oral life history method which has 12 women's personal narratives and 17 women's personal narratives with written reports was used as a research method of this study. The results of the study were obtained as follows: 1) It was beginning about late 1970 year that heating system and cooking place were separated in a house. 2) Many kitchens were reconstructed for indoor stand-up work place from late 1970's to the early 1980's. 3) There were major factors such as heating system, cooking fuel, and work center in the change of kitchen in old houses. 4) The kitchen toward the center with a living room was appeared in the floor plan of modem house after 1990's. The symbolic words of the indoor kitchen that work for women were 'warmness' and 'convenience'.

흰쥐 재생 간에서의 K - ras 유전자 발현

박선희,이승기,박종상 ( Sun Hee Park,Seung Ki Lee,Jong Sang Park ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.1

K-ras gene expression in the regenerating liver of the patial hepatectomy was tested by using dot hybridization. The K-ras gene transcription after the patial hepatectomy is amplified and its RNA splicing patern is changed. In normal liver exon 4a is spliced out and only K-ras proteins containing exon 4b are produced. In regenerating liver exon 4b is spliced out and K-ras proteins containing exon 4a might be produced at least 1000% more than in the normal liver.