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탄수화물 급원에 따른 HCA의 공급이 흰쥐의 체중 및 지질 대사에 미치는 영향
손영애(Son Young-Ae),정혜진(Jeong Hyejin),심지애(Shim Jee Ae),권상희(Kwon Sanghee),김미경(Kim Mi Kyung) 韓國營養學會 2007 Journal of Nutrition and Health Vol.40 No.8
This study was conducted to investigate the effects of feeding different carbohydrate sources and garcinia cambogia extract (HCA) on body weight and lipid metabolism. Fifty l0-month-old male Sprague-Dawley rats weighting 635 ±6g were randomly divided into 5 groups and fed different experimental diets for 4 weeks. The carbohydrate (CHO) sources of each group were cornstarch (control group, 100% of CHO), fructose (F group and FH group, 25% of CHO) and sucrose (S group and SH group, 25% of CHO). FH group and SH group were fed diets containing 1% (W/W) of HCA. Food intake, body weight gain, and calorie efficiency were not significantly different among the groups. Perirenal fat pad weight of FH group was significantly lower than F group, but epididymal fat pad weight was not different among the groups. Fasting glucose level were not significant among the groups. Plasma lipid profile of FH or SH group was slightly lower than F or S group, respectively. The degree of difference of plasma lipid level was greater between F and FH group than those of between S and SH group. In liver, total lipid, triglyceride and total cholesterol level were slightly higher in F group than S group, and tended to be lower in FH group than F group, but tended to be higher in SH group than S group. Liver citrate lyase activity were not significant among the groups. These results suggest that HCA is potential material for reduction of body weight and improvement of plasma lipid profiles. But, there was no difference between fructose intake with HCA and sucrose intake with HCA in reduction of body weight and lipid metabolism.