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기억장애성 경도인지장애 환자에서 해마대사량의 감소: 양전자방출단층촬영연구
박찬흠(Chan hum Park),이영민(Young Min Lee),박제민(JeMin Park),이병대(Byung Dae Lee),문은수(EunSoo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),서화규(Hwagyu Suh),박혜경(Hye Kyung Park),김학진(Hak-Jin Kim) 대한노인정신의학회 2020 노인정신의학 Vol.24 No.1
Objective: Little is known about factors influencing of hippocampal metabolism (HM) in mild cognitive impairment (MCI). Our objective was to determine whether HM in patients with amnestic MCI (aMCI) is decreased than non-amnestic MCI (naMCI). Methods: Overall, 32 MCI patients underwent 18F-fluorodeoxyglucose-positron emission tomography. They were characterized as aMCI (n=18) or naMCI (n=14) according to comprehensive neuropsychological criteria. Analysis of variances were used to assess differences on HM between aMCI and naMCI after controlling age, sex, education and Korean version of Mini Mental Status Examination. Results: We found that HM was more decreased in aMCI than naMCI. This result was not changed after controlling hippocampal volume. Conclusion: Our findings suggest that aMCI is associated with decreased HM in MCI.
태아기 성호르몬이 여성의 알츠하이머병의 발병에 미치는 영향 : 2D/4D 손가락 길이 비율을 이용한 단면 연구
강태욱(Tae Uk Kang),이영민(Young Min Lee),박제민(Je Min Park),이병대(Byung Dae Lee),문은수(Eunsoo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),서화규(Hwagyu Suh),정영인(Young-In Chung) 대한노인정신의학회 2020 노인정신의학 Vol.24 No.2
Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD). Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference. Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls. Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
한국인 조현병 집단에서 활동의존신경보호단백질-2(ADNP2 ) 유전자의 가족연합분석 : 예비연구
김유준(Yoo Jun Kim),이병대(Byung Dae Lee),박제민(Je Min Park),이영민(Young Min Lee),문은수(Eunsoo Moon),정희정(Hee Jeong Jeong),김수연(Soo Yeon Kim),이강윤(Kang Yoon Lee),서화규(Hwagyu Suh) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.3
Objectives:It is found that imbalance in activity-dependent neuroprotective protein(ADNP) and the homologous protein ADNP2 in schizophrenia may impact the disease progression. Yet, further research is required to clarify their connection to schizophrenia. This is a pilot study for a family-based association analysis of ADNP2 gene in a Korean population with schizophrenia. Methods:Twenty-seven probands with schizophrenia were recruited with their parents and siblings. We have used lifetime dimensions of psychosis scale for measuring psychotic features. Promising endophenotypic markers such as age at interview, apparent onset, apparent onset of psychosis, and first treatment age were also included. We analyzed 2 single nucleotide polymorphisms (SNPs) of ADNP gene. Then, we performed family based association test(FBAT) and linkage disequilibrium analyses for each individual SNPs. Results:A significant SNP of ADNP2 gene in chromosome 18 (p-value<0.05) for the qualitative phenotype of schizophrenia was found (rs575682; ADNP2). The result was replicated for the quantitative phenotype of apparent onset, apparent onset of psychosis, and the first treatment age. We also found one significant SNP of ADNP2 gene in chromosome 18 (p-value<0.05) for the quantitative phenotype of any delusions. (rs575682; ADNP2) No SNPs were found for the quantitative phenotype of any hallucinations. Conclusion:Our results showed that quantitative traits such as age of onset, any delusions, and any hallucinations could be continuous with qualitative trait in schizophrenia. However, a caution must be taken in interpreting these results because there were clear limitations in FBAT analyses which included nominal number of SNPs in the small incomplete pedigrees.
한국인 조현병 집단에서 에스트로겐 대사(ESR1, COMT) 유전자의 가족연합분석: 예비연구
이연수(Soo Yeon Lee),이병대(Byung Dae Lee),박제민(Je Min Park),이영민(Young Min Lee),문은수(Eunsoo Moon),정희정(Hee Jeong Jeong),정우영(Woo Young Jung),서화규(Hwagyu Suh),김경원(Kyungwon Kim) 대한생물치료정신의학회 2021 생물치료정신의학 Vol.27 No.3
Objectives:A recent study of a European sample implied that the 14 genes previously known to be related with schizophrenia may play little roles. But much work remains before dismissing these genes from their connection to schizophrenia. This is a pilot study for family based association test (FBAT) analysis of estrogen metabolism gene in a Korean population with schizophrenia. Methods:27 probands with schizophrenia were recruited with their parents and siblings. The subjects were interviewed using Korean versions of diagnostic interview for genetic studies and family interview for genetic studies. We analyzed 2 single nucleotide polymorphism (SNP) of ESR1, COMT gene. We performed FBAT and linkage disequilibrium analyses for each individual SNP. Results:We found a significant SNP of ESR1 gene in chromosome 6 for the qualitative phenotype of schizophrenia. That result was replicated for the quantitative phenotype of apparent onset, apparent onset of psychosis, and first treatment age. We also found a significant SNP of ESR1 gene in chromosome 6 for the quantitative phenotype of any delusions. Conclusions:Our results show that quantitative traits such as age of onset, any delusions, and any hallucinations could be continuous with qualitative trait in schizophrenia. But we should be very cautious because there are clear limitations in some nominal number of SNPs and the small incomplete pedigrees. In the future, FBAT analyses in families with subtyped schizophrenic probands according to personality, working memory, cognition will facilitate fine mapping analyses for searching candidate genes of schizophrenia.