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사염화탄소에 의한 흰쥐의 간손상에서 조직인자의 발현에 대한 내독소의 영향
조몽 ( Jo Mong ),서수분 ( Seo Su Bun ),허정 ( Heo Jeong ),김광하 ( Kim Gwang Ha ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),양웅석 ( Yang Ung Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: Endotoxemia is known to cause hepatic microcirculation disturbance and hepatic injury through blood coagulation and thromobosis in the cirrhotic patients. This study was to investigate the effect of endotoxin on the expression of tissue factor in rat liver with persistent injury. Methods: Male Sprague-Dawley rats were used for this experiment. Persistent hepatic injury was induced by injecting 0.1 mL of CCl4 and 0.1 mL of mineral oil per 100 grams of body weight, intraperitoneally. Twenty-four rats were divided into 4 groups and lipopolysacharide (LPS, E. coli O111:B4) was injected intraperitoneally in 3 groups in a dose of 200 ㎍/kg, 400 ㎍/kg, and 800 ㎍/kg, respectively. Expression of tissue factor was evaluated by real time PCR method. SYBR Green I, a DNA binding fluorophore was used for the detection of PCR product. Results: Expression of hepatic tissue factor tended to increase according to the amounts of LPS. Specially, the expression of tissue factor was significantly increased in the group into which 400 ㎍/kg of LPS was injected, compared with control group (p<0.05). Conclusions: Expression of tissue factor tends to increase according to the amounts of LPS in the persistent hepatic injury. LPS may play an important role in the expression of tissue factor in the CCl4-treated rat liver. (Korean J Gastroenterol 2003;42:149-155)
대장암에서 CDX1 mRNA 및 CDX2 mRNA의 발현에 관한 연구
김형욱 ( Kim Hyeong Ug ),이동현 ( Lee Dong Hyeon ),김광하 ( Kim Gwang Ha ),허정 ( Heo Jeong ),박도윤 ( Park Do Yun ),서수분 ( Seo Su Bun ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),조몽 ( Jo Mong ),양웅석 ( Yang Ung Seog 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<배경 및 목적> Caudal-type homeobox gene family인 CDX1과 CDX2는 장 상피세포의 증식 및 분화를 조절하는 데에 중요한 역할을 하는 유전자로, 대장암에서 발현이 감소되는 것으로 알려져 있다. 현재까지 CDX1 및 CDX2 발현 정도가 대장암의 임상병리학적 인자에 미치는 영향에 대한 연구는 드물다. 이에 본 연구에서는 대장암에서 CDX1 mRNA 및 CDX2 mRNA 발현 정도를 조사하여 임상병리학적 인자와의 연관성을 알아