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사염화탄소에 의한 흰쥐의 간손상에서 조직인자의 발현에 대한 내독소의 영향
조몽 ( Jo Mong ),서수분 ( Seo Su Bun ),허정 ( Heo Jeong ),김광하 ( Kim Gwang Ha ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),양웅석 ( Yang Ung Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: Endotoxemia is known to cause hepatic microcirculation disturbance and hepatic injury through blood coagulation and thromobosis in the cirrhotic patients. This study was to investigate the effect of endotoxin on the expression of tissue factor in rat liver with persistent injury. Methods: Male Sprague-Dawley rats were used for this experiment. Persistent hepatic injury was induced by injecting 0.1 mL of CCl4 and 0.1 mL of mineral oil per 100 grams of body weight, intraperitoneally. Twenty-four rats were divided into 4 groups and lipopolysacharide (LPS, E. coli O111:B4) was injected intraperitoneally in 3 groups in a dose of 200 ㎍/kg, 400 ㎍/kg, and 800 ㎍/kg, respectively. Expression of tissue factor was evaluated by real time PCR method. SYBR Green I, a DNA binding fluorophore was used for the detection of PCR product. Results: Expression of hepatic tissue factor tended to increase according to the amounts of LPS. Specially, the expression of tissue factor was significantly increased in the group into which 400 ㎍/kg of LPS was injected, compared with control group (p<0.05). Conclusions: Expression of tissue factor tends to increase according to the amounts of LPS in the persistent hepatic injury. LPS may play an important role in the expression of tissue factor in the CCl4-treated rat liver. (Korean J Gastroenterol 2003;42:149-155)
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; 한국인 만성 간질환 환자에서 간성 골이형성증의 유병률: 간염과 간경변 환자 비교
정을조 ( Jeong Eul Jo ),허정 ( Heo Jeong ),김광하 ( Kim Gwang Ha ),배용목 ( Bae Yong Mog ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),조몽 ( Jo Mong ),양웅석 ( Yang Ung Seog ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
김광하(Gwang Ha Kim),배용목(Yong Mock Bae),정을조(Eul Jo Jeong),문재현(Jae Hyeon Moon),안진광(Jin Kwang An),김진선(Jin Seon Kim),허정(Jeong Heo),강대환(Dae Hwan Kang),송근암(Geun Am Song),조몽(Mong Cho),양웅석(Ung Suk Yang) 대한내과학회 2002 대한내과학회지 Vol.63 No.4
목적 : 저진폭 수축파와 연동운동 단절은 식도 내용물의 부적절한 배출과 역류와 연관성이 있어 기능적·임상적 중요성을 가진다. 이런 이유로 비특이성 식도운동장애(NEMD)에서 구분하여 비효율적 식도운동(IEM) 이라는 새로운 진단명이 제시되고 있다. 이에 저자들은 산역류가 있는 IEM 환자에서 식도 산청소능을 조사하고자 하였다. 방법 : 2001년 6월부터 2002년 5월까지 쉰 목소리, 인후 이물감, 흉통 등으로 식도운동검사와 보행성 식도산도검사를 시행 받은 252예 중에서 산역류를 보이는 정상식도운동군 51명(남:여 18:33, 평균 48.0세)과 IEM군 40명(남;여, 16:24, 평균 48.6세)을 대상으로 하여 식도운동검사와 보행성 식도산도검사 결과를 비교분석하였다. 적어도 wet swallow의 30% 이상에서 원위부 식도의 저수축 소견이 관찰되는 경우를 IEM으로 진단하였으며. 식도 산청소능은 원위부 식도 pH가 4 미만인 전체 시간(분)을 총 역류 횟수로 나눈 값으로 정의하여 양군 간에 결과를 비교분석하였다. 결과 : 1) IEM군에서 근위부 식도와 원위부 식도 수축파의 진폭, 하부식도괄약근압은 각각 47.3±21.9 mmHg, 60.0±27.5 mmHg, 18.0±6.7 mmHg로, 정상식도운동군(66.5±22.6 mmHg, 100.3±31.8 mmHg, 29.5±8.4 mmHg)보다 유의하게 낮았다(p<0.05). 2) IEM군에서 전체 검사시간 중, 기립시, 앙와위시 pH 4 미만인 전체 측정시간 백분율은 0.78±1.08%, 1.05±1.55%, 0.42±1.16%로, 정상식도운동군(각각 0.55±0.85%, 0.85±1.31%, 0.14±0.41%)과 유의한 차이는 없었다(p>0.05). 또한, 전체 측정시간 중 pH 4 미만의 역류가 일어난 횟수, 전체 측정시간 중 pH 4 미만의 역류가 5분 이상 일어난 횟수, Demeester 종합점수, 최장역류시간도 양군간에 유의한 차이는 없었다(p>0.05). 3) IEM군에서 앙와위시 식도 산청소능은 0.73±0.64분/회로, 정상식도운동군 0.31±0.29분/회보다 유의하게 증가되어 있었다(p=0.021). 하지만 기립시 식도 산청소능은 IEM군 0.51±0.42분/회, 정상식도운동군 0.41±0.40분/회으로 양군간에 유의한 차이는 없었다(p=0.096). 결론 : IEM군에서 정상식도운동군보다 앙와위시 유의한 식도 산청소능 증가가 관찰되었다. IEM이 위식도역류질환(GERD)에서 흔히 관찰되는 것을 고려한다면, IEM시 보다 더 적극적인 항역류 치료가 필요하며, 차후 GERD의 장기합병증과의 관련성에 대한 연구도 필요할 것으로 보인다. 이러한 상황을 고려해 볼 때 IEM은 NEMD에서 분리하여 독립된 운동질환으로 분류하는 것이 바람직하리라 사료된다. Background : Failed or hypotensive peristalsis, two of the diagnostic criteria for NEMD, correlates with impaired anterograde propulsion and retrograde escape of esophageal contents. The aim of this study was to evaluate esophageal acid clearance (EAC) in patients with ineffective esophageal motility (IEM). Methods : Of 252 patients performing esophageal manometry and ambulatory esophageal pH monitoring, 51 patients with normal motility and acid reflux and 40 patients with IEM and acid reflux were included. Results : The amplitude of peristaltic waves in the proximal and distal esophagus and lower esophageal sphincter pressure was lower significantly in patients with IEM than those with normal motility. Percentage of time of pH<4 in total, upright, and supine period and number of reflux episodes was not different in both. Supine EAC was significantly increased in patients with IEM when compared to those with normal motility. Upright EAC was not different in both. Conclusion : We concluded supine EAC is increased in patients with IEM. Since IEM is frequently associated with gastroesophageal reflux disease (GERD), a more intensive therapy must be needed. We propose IEM can be as a specific entity of primary esophageal motility disorder, especially in patients with GERD.(Korean J Med 63:386-393, 2002)
간장 및 담도 : 간상해를 동반한 당뇨병 - 특히 HBs Ag 양성빈도 및 동위원소 간 소견 -
유방현(Bang Hyun Liu),김성은(Seong Eun Kim),도창호(Chang Ho Do),이형유(Hyeong Yoo Lee),조몽(Mong Jo) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.1
N/A To evaluate of the possibility of diabetes mellitus in the precipitating factor of liver cirrhosis, the authors have made a clinical analysis on 56 patients of diabetes mellitus with chronic hepatopathy (Cirrhotic Liver Group (29 cases): Noncirrhotic Liver Group (27 cases)} who were admitted at Pusan National University Hospital from Feb. 1987 to Jun. 1989. The results were as follows; 1) The mean age of DM group with cirrhosis was significantly older than that of DM group without cirrhosis (p<0.01). 2) On duration of DM, especially more than 6 years, DM group with cirrhosis was longer than that of DM group without cirrhosis (62% : 32%). 3) On fasting blood sugar level, especially more than 201 mg%, DM group with cirrhosis was higher than that of DM group without cirrhosis, and in cirrhotic group complications of portal hypertension were higher in high FBS level cases. 4) On body weight, especially range of IBW +- 10%, DM group with girrhosis was less controlled than DM group without cirrhosis (41% : 59%). 5) On complications of DM, both group are 76% and 71%, respectively, and the high incidence of complication suggest that duration of DM was long. 6) The positive rate of HBs Ag in DM group with cirrhosis was significantly higher than that of DM group without cirrhosis (28% : 4%, p<0.05). 7) On chemical liver function studies, DM group with cirrhosis showed more increased abnormal value except SGPT, total protein than that of DM group without cirrhosis. 8) On comparison of liver size by radiosotope liver scan, DM group with cirrhosis was smaller than that of DM group without cirrhosis (9.70 +- 1.59:12.68 +- 1.16, p<0.001). 9) On radiosotope liver scan, mottling of DM group with cirrhosis was coarse, but DM group without cirrhosis was fine (p<0.005), and spleen visualization in DM group with cirrhosis was more significant than that of DM group without cirrhosis (92% : 40%, p<0.001).
대간간학회지 제6차 춘계학술대회 초록집 : 구연 ; 사염화탄소에 의해 유발된 흰쥐의 간손상에서 Cyclooxygenase-2 의 발현과 NF-κB의 결합능
김상현 ( Kim Sang Hyeon ),이재승 ( Lee Jae Seung ),서경덕 ( Seo Gyeong Deog ),정해영 ( Jeong Hae Yeong ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),조몽 ( Jo Mong ),양웅석 ( Yang Ung Seog ) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)