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실리콘겔 인공유방의 기계적 및 물리화학적 특성에 대한 연구
백홍,장동혁,송정민,이승영,서무엽,박길종,맹은호,Baek, H.,Jang, D.H.,Song, J.M.,Lee, S.Y.,Seo, M.Y.,Park, G.J.,Maeng, E.H. 대한의용생체공학회 2012 의공학회지 Vol.33 No.2
The purpose of this study is to develop the guideline of the physicochemical and mechanical properties evaluation for silicone gel filled breast implants. First of all, the use and development status for silicone gel filled breast implants were investigated, and then, standard and criteria about performance evaluation established by the international organizations such as ASTM, FDA guidance and ISO were examined. To evaluate the mechanical properties, data research and testing for breaking strength, elongation, tensile set, joint intensity, silicone gel cohesion, weight loss from heating, static rupture resistance, impact resistance test, fatigue test, and gel bleed were performed. On the other hand, to evaluate the physicochemical properties, volatile matter, extent of cross linking, heavy metals, and extractable were analyzed. In this study, results for general function, mechanical properties and physicochemical properties were examined and reviewed for the accordance with international standard, and objective and standardized guideline was provided.
송정민,백홍,이승영,장동혁,서무엽,박길종,맹은호,Song, J.M.,Baek, H.,Lee, S.Y.,Jang, D.H.,Seo, M.Y.,Park, G.J.,Maeng, Eun-Ho 대한의용생체공학회 2013 의공학회지 Vol.34 No.2
The goal of this study is to develop test method for evaluating the drug eluting properties of drug eluting stents (DES). PBS and the detergent solutions, presented by each DES manufacturer, were used for drug release of DES coated with paclitaxel, zotarolimus and everolimus. The drugs which are coating DES were not released by PBS but released by the detergent solutions, finally paclitaxel 83.38%, zotarolimus 103.85% and everolimus 115.78%. It seems that the use of the detergents is necessary in order to release the drugs because those drugs are extremely hydrophobic. In conclusion, using of detergent solutions presented by each manufacturer were suitable for evaluating the drug eluting property of drug eluting stent.