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간 보호제 및 담즙산류들이 마크로파지 세포주에서 TNF-alpha 분비에 미치는 효과
조재열(Jae Youl Cho),박지수(Ji Soo Park),유은숙(Eun Sook Yoo),백경업(Kyong Up Baik),박명환(Myung Hwan Park) 대한약학회 1998 약학회지 Vol.42 No.1
The effect of hepatoprotective agents and bile acids on tumor necrosis factor-alpha, (TNF-alpha) production in murine and human macrophage cell line (RAW264.7 and U937) was investigated. The hepatoprotective agents including silymarin and its major component, silybin, significantly inhibited TNF-alpha production in a concentration dependent manner (IC50 of silybin=67.7mcg/ml (140.3mcM)). In differentiated U937 cells, especially, silybin showed more effective inbitory activity (IC50=35.1mcg/ml (72.7mcM)). These results suggest that silymarin and silybin may inhibit TNF-alpha production in the process of hepatic diseases in human. However, biphenyldimethyl dicarboxylate (DDB) was not effective. In the case of bile acids, chenodeoxycholic acid (CDCA) showed a concentration dependent inhibitory effect on TNF-alpha production (IC50 of CDCA= 71.5mcg/ml (182.1mcM)). In contrast, glycine or taurine conjugated form (G-CDCA or T-CDCA) restored to the control level or significantly increased TNF-alpha production. And also ursodeoxycholic acid (UDCA) and its conjugated forms (G-UDCA and T-UDCA) showed a variety of patterns on TNF-alpha production by changes of functional groups and concentration. These results also indicate that bile acids may regulate TNF-alpha production in normal hepatic function or disease conditions.
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인삼 사포닌류가 종양괴사인자의 생성 및 T 세포 증식에 미치는 효과
조재열(Jae Youl Cho),박지수(Ji Soo Park),유은숙(Eun Sook Yoo),백경업(Kyong Up Baik),박명환(Myung Hwan Park),한병훈(Byung Hoon Han) 대한약학회 1998 약학회지 Vol.42 No.3
To investigate the effects of ginsenosides from Panax ginseng on mitogenic responses in macrophages and splenocytes from murine, we examined the effects of representative protopanaxadiol and protopanaxatriol ginsenosides (Rb1, Rb2, Re and Rg1) on tumor necrosis factor-alpha (TNF-(alpha) production in and smurine macrophage cell line (RAW264.7 cells) stimulated by lipopolysaccharide (LPS) and T cell proliferation in splenocytes stimulated by concanavalin A (Con A). Among the ginsenosides tested, protopanaxadiol ginsenosides (Rb1 and Rb2) significantly inhibited TNF-alpha production in a dose-dependent manner. However, protoppanaxatriol ginsenosides (Re and Rg1) showed little inhibitory activity. The molar concentrations of Rb1 and Rb2 producing 50% inhibition (IC50) of TNF-alpha production were 55.8mcg/ml (48.0mcM) and 31.8mcg/ml (27.9mcM), respectively. As a positive control, prednisolone also exhibited inhibitory activity with an IC50 value of 21.7mcM. In T cell proliferation, Rg1, was not effective but Rb1 and Re or Rb2 significantly increased or inhibited at high concentration, 75 and 100mcg/ml. In contrast, prednisolone showed potent inhibitory activity with an IC50 value of 6.1nM. These results suggest that ginsenosides may take part in the mitogen-induced signaling pathway for TNF-alpha production and T cell proliferation from macrophages splenocytes.
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