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소아 호산구 증가증의 원인과 빈도: 1년간 단일 기관 연구
김경민 ( Kyung Min Kim ),배미혜 ( Mi Hye Bae ),김영미 ( Young Mi Kim ),조민정 ( Min Jung Cho ),곽민정 ( Min Jung Kwak ),김성헌 ( Seong Heon Kim ),손승국 ( Seung Kook Son ),박희주 ( Hee Ju Park ),김혜영 ( Hye Young Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.5
Purpose: Eosinophilia may be associated with various primary and reactive conditions. However, studies on the cause and incidence of eosinophilia in Korean children are rare. This study aimed to evaluate the cause and incidence of eosinophilia in patients at a single university hospital. Methods: We studied 8,285 pediatric patients under the age of 18 years who had eosinophilia at Pusan National University Hospital. Premature and newborn infants were excluded. Eosinophilia was defined as an absolute eosinophil count greater than 450/μL. Eosinophilia was categorized as mild (450-1,500/μL), moderate (1,500-5,000/μL), and severe (>5,000/μL). The underlying conditions of eosinophilia were retrospectively investigated. Results: Of 8,285 patients who had a hematology profile, 497 (5.9%) were found to have eosinophilia. Of patients with eosinophilia, 333 patients (67.0%) had identifiable and possible causes. The major causes of eosinophilia were allergic diseases (61.3%), infectious diseases (19.8%), immunologic diseases (9.0%) and hemato-oncologic disease (5.1%). Immunological disease such as Idiopathic hypereosinophilic syndrome, drug induced hypersensitivity syndrome and Graft-versus-host disease was the common condition with moderate to severe eosinophilia in which eosinophil count in peripheral blood was more than 1,500/μL. Conclusion: The most common cause of eosinophilia was allergic disease. Immunological disease was the common condition with moderate to severe eosinophilia.(Allergy Asthma Respir Dis 2014;2:358-361)
단일 기관 태변 흡인 증후군의 인공호흡기 사용여부에 따른 임상적 특성
임령경 ( Ryoung Kyoung Lim ),배미혜 ( Mi Hye Bae ),김아영 ( Ah Young Kim ),한영미 ( Young Mi Han ),박경희 ( Kyung Hee Park ),변신연 ( Shin Yun Byun ) 대한주산의학회 2015 Perinatology Vol.26 No.2
Purpose: Meconium aspiration syndrome is an important cause of neonatal morbidity and mortality, and sometimes patients need mechanical ventilator therapy. The aim of this study was to identify the risk factors which required mechanical ventilation. Methods: We retrospectively analyzed 44 infants diagnosed as meconium aspiration syndrome from January 2009 to December 2013. We divided into 2 groups (ventilator group and oxygen therapy group) and analyzed the clinical characteristics, vital signs, laboratory findings and clinical courses. Results: Ventilator group and oxygen therapy group included each 22 infants, and there were no significant differences in clinical characteristics between two groups. Time to transfer and time to start oxygen therapy were longer in ventilator group but not statistical difference. Initial mean blood pressure and pH were significantly lower in ventilator group than in oxygen therapy group (P=0.026, P=0.003). Ventilator group had longer treatment period and worse prognosis than oxygen therapy group. Conclusion: If the infants with meconium aspiration and respiratory distress represent low pH and hypotension, we have to pay close attention to early oxygen supplementation and proper treatment to prevent poor clinical course.
이나래 ( Narae Lee ),정문희 ( Mun Hui Jeong ),정성희 ( Seong Hee Jeong ),배미혜 ( Mi-Hye Bae ),한영미 ( Young Mi Han ),박경희 ( Kyung-Hee Park ) 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.3
Purpose: Syphilis infections are becoming more prevalent in the Republic of Korea, and inadequately treated syphilis can lead to congenital syphilis (CS) in newborns. This study aimed to analyze the clinical manifestations of syphilis in mothers and newborns and to make suggestions to improve disease prognosis. Methods: This single-center study was performed between August 2009 and August 2019 and included 29 newborns with CS. We retrospectively evaluated the clinical features, rapid plasma reagin (RPR) card test, fluorescent treponemal antibody absorption test (FTA-ABS), morbidity, and treatment regimen of all the syphilis-affected mothers and their newborns. Results: At the time of delivery, mean maternal age was 29.0±6.1 years old, and newborn gestational age was 38.0 weeks. In cases when syphilis was confirmed during the second and third trimesters of pregnancy, the newborn with CS had morbidity (p=0.004). The mean RPR titer was related to morbidity (p= 0.036). Positive results of FTA-ABS IgM (p<0.001) and pleocytosis in the cerebrospinal fluid (CSF) (p= 0.020) also increase morbidity. The most common symptoms were desquamation and skin rash, followed by hepatomegaly, neurodevelopmental disability, and bone abnormalities. The highest number of CS cases per 1,000 live births in this hospital was in 2014. Conclusion: CS is a preventable and treatable disease if physicians detect symptoms and provide appropriate treatment through RPR examinations during every trimester. General practitioners should be widely trained on various aspects including early detection, formal treatment, and regular follow-up. Additionally, medical services should be provided for the entire childbearing population regardless of the socioeconomic status.